Biomolecules, Год журнала: 2025, Номер 15(3), С. 450 - 450
Опубликована: Март 20, 2025
Implantation is a complex and tightly regulated process essential for the establishment of pregnancy. It involves dynamic interactions between receptive uterus competent embryo, orchestrated by ovarian hormones such as estrogen progesterone. These regulate proliferation, differentiation, gene expression within three primary uterine tissue types: myometrium, stroma, epithelium. Advances in genetic manipulation, particularly Cre/loxP system, have enabled vivo investigation role genes compartmental cell type-specific manner, providing valuable insights into biology during pregnancy disease. The development endometrial organoids has further revolutionized implantation research. They mimic native structure function, offering powerful platform studying hormonal responses, implantation, maternal-fetal interactions. Combined with omics technologies, these models uncovered molecular mechanisms signaling pathways that implantation. This review provides comprehensive overview uterine-specific tools, organoids, omics. We explore how advancements enhance our understanding biology, receptivity, decidualization reproductive
Язык: Английский