The Sensitive Genes for Cervical Cancer: Two-Sample Mendelian Randomization with Experimental Validation DOI Creative Commons
Rong Zhang, Shengjun Chai, Qihang Chen

и другие.

International Journal of Women s Health, Год журнала: 2025, Номер Volume 17, С. 1511 - 1532

Опубликована: Май 1, 2025

Cervical cancer, the fourth leading cause of female cancer mortality globally, faces treatment limitations due to drug resistance and few therapeutic options. This study seeks identify novel targets address this urgent clinical need. Our team identified differentially expressed genes (DEGs) in cervical using gene expression omnibus (GEO) datasets. Subsequently, Mendelian randomization (MR) analysis causal gene-cancer relationships, followed by enrichment The Cancer Genome Atlas (TCGA) validation. Finally, we further validated functions selected target cells analyzed their Gene Set Enrichment Analysis (GSEA) results, sensitivity, prognostic value. We 2,801 upregulated 1,646 downregulated DEGs. MR 21 key cancer-associated (14 upregulated, 7 downregulated), with TCGA validation confirming significant differential patterns. Among them, studies have examined these core genes, particularly MERTK SERPINF1, cancer. Experiments showed that SERPINF1 play a role These help grow, spread, invade surrounding tissue. Mechanistically, regulates immune infiltration, whereas modulates chromosomal activity. Clinically, enhances overall survival (OS), disease-specific (DSS), progression-free interval (PFI) individuals Moreover, discovered several commonly used drugs for treatment, like paclitaxel, high efficacy against SERPINF1. uncovers as critical regulators progression survival, offering mechanistic insights into roles tumor behavior microenvironment. findings provide foundation precision therapies, restoration inhibition promising strategies. Clinical translation could current limitations.

Язык: Английский

LINC01559: roles, mechanisms, and clinical implications in human cancers DOI
Shuwen Zhang, Xin Lan, Lei Liu

и другие.

Human Cell, Год журнала: 2025, Номер 38(3)

Опубликована: Апрель 9, 2025

Язык: Английский

Процитировано

0
Macrophage polarization in hepatocellular carcinoma: a lncRNA-centric perspective on tumor progression and metastasis DOI Creative Commons

Ahmad Ghorbani Vanan,

Mohammad Nami, Farid Ghorbaninezhad

и другие.

Clinical and Experimental Medicine, Год журнала: 2025, Номер 25(1)

Опубликована: Май 25, 2025

Hepatocellular carcinoma (HCC) represents a multifaceted and aggressive cancer frequently associated with chronic inflammation immune cell activation. The pathogenesis of HCC is influenced by variety factors such as long non-coding RNAs (lncRNAs). LncRNAs, significant class RNAs, contribute to the intricate nature transcriptome are extensively distributed across various tissues types in mammals. In HCC, these transcripts crucial not only for deepening our molecular understanding but also advancing clinical outcomes, they serve both oncogenes tumor suppressors dysregulating essential genes signaling pathways. Additionally, macrophage polarization progression. study explores role lncRNAs hepatocellular elucidates specific mechanisms which key HULC MALAT1 regulate microenvironment. These modulate cytokine profiles influence regulators including IL-10 TGF-β, steering macrophages toward an M2-like, pro-tumor phenotype that fosters characteristics Mechanistically, interact epigenetic modifiers like EZH2 alter histone modifications chromatin accessibility, while stabilizing mRNAs encode inflammatory mediators, thereby reinforcing immunosuppressive response. implications findings substantial. detection patient samples offers minimally invasive diagnostic avenue, their pivotal complex behavior positions them promising prognostic biomarkers. Moreover, targeting may lead innovative therapeutic strategies aimed at disrupting tumor-supportive cascades restoring effective antitumor Understanding interplay between lncRNA-mediated regulation refines grasp progression opens new pathways interventions designed improve outcomes.

Язык: Английский

Процитировано

0
The Sensitive Genes for Cervical Cancer: Two-Sample Mendelian Randomization with Experimental Validation DOI Creative Commons
Rong Zhang, Shengjun Chai, Qihang Chen

и другие.

International Journal of Women s Health, Год журнала: 2025, Номер Volume 17, С. 1511 - 1532

Опубликована: Май 1, 2025

Cervical cancer, the fourth leading cause of female cancer mortality globally, faces treatment limitations due to drug resistance and few therapeutic options. This study seeks identify novel targets address this urgent clinical need. Our team identified differentially expressed genes (DEGs) in cervical using gene expression omnibus (GEO) datasets. Subsequently, Mendelian randomization (MR) analysis causal gene-cancer relationships, followed by enrichment The Cancer Genome Atlas (TCGA) validation. Finally, we further validated functions selected target cells analyzed their Gene Set Enrichment Analysis (GSEA) results, sensitivity, prognostic value. We 2,801 upregulated 1,646 downregulated DEGs. MR 21 key cancer-associated (14 upregulated, 7 downregulated), with TCGA validation confirming significant differential patterns. Among them, studies have examined these core genes, particularly MERTK SERPINF1, cancer. Experiments showed that SERPINF1 play a role These help grow, spread, invade surrounding tissue. Mechanistically, regulates immune infiltration, whereas modulates chromosomal activity. Clinically, enhances overall survival (OS), disease-specific (DSS), progression-free interval (PFI) individuals Moreover, discovered several commonly used drugs for treatment, like paclitaxel, high efficacy against SERPINF1. uncovers as critical regulators progression survival, offering mechanistic insights into roles tumor behavior microenvironment. findings provide foundation precision therapies, restoration inhibition promising strategies. Clinical translation could current limitations.

Язык: Английский

Процитировано

0