Links between short-chain fatty acids and osteoarthritis from pathology to clinic via gut-joint axis DOI Creative Commons
Juanjuan Han, Xin Meng, Hui Kong

и другие.

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Май 19, 2025

Short-chain fatty acids (SCFAs), the primary metabolites produced by microbial fermentation of dietary fibers in gut, have a key role protecting gut health. Increasing evidence indicates SCFAs can exert effects on distant tissues and organs beyond via blood circulation. Osteoarthritis (OA) is chronic inflammatory joint disease that severely diminishes physical function quality life. However, effective clinical treatments for OA remain elusive. Recent studies shown beneficial damaged joints OA. mitigate progression preserving intestinal barrier maintaining integrity cartilage subchondral bone, suggesting they substantial potential to be adjunctive treatment strategy This review described human body their cellular signaling mechanism, summarized multiple (especially butyrate, propionate, acetate) prevention regulating gut-joint axis, providing novel insights into promising applications.

Язык: Английский

Links between short-chain fatty acids and osteoarthritis from pathology to clinic via gut-joint axis DOI Creative Commons
Juanjuan Han, Xin Meng, Hui Kong

и другие.

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Май 19, 2025

Short-chain fatty acids (SCFAs), the primary metabolites produced by microbial fermentation of dietary fibers in gut, have a key role protecting gut health. Increasing evidence indicates SCFAs can exert effects on distant tissues and organs beyond via blood circulation. Osteoarthritis (OA) is chronic inflammatory joint disease that severely diminishes physical function quality life. However, effective clinical treatments for OA remain elusive. Recent studies shown beneficial damaged joints OA. mitigate progression preserving intestinal barrier maintaining integrity cartilage subchondral bone, suggesting they substantial potential to be adjunctive treatment strategy This review described human body their cellular signaling mechanism, summarized multiple (especially butyrate, propionate, acetate) prevention regulating gut-joint axis, providing novel insights into promising applications.

Язык: Английский

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