A review on recent progress in synthesis and biological activities of spiropyrrolidine and its derivatives

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141377 - 141377

Опубликована: Янв. 1, 2025

Язык: Английский

---

Sonochemistry in an organocatalytic domino reaction: an expedient multicomponent access to structurally functionalized dihydropyrano[3,2-b]pyrans, spiro-pyrano[3,2-b]pyrans, and spiro-indenoquinoxaline-pyranopyrans under ambient conditions

RSC Advances, Год журнала: 2022, Номер 12(20), С. 12843 - 12857

Опубликована: Янв. 1, 2022

A highly convenient and sustainable one-pot approach for the diversely-oriented synthesis of a variety medicinally privileged amino-substituted 4,8-dihydropyrano[3,2-

Язык: Английский

---

Transition‐Metal‐Free Synthesis of N‐Heterocyclic Compounds via Multi‐Component Reactions

Asian Journal of Organic Chemistry, Год журнала: 2023, Номер 12(9)

Опубликована: Июль 29, 2023

Abstract Multicomponent reactions (MCRs) have emerged as powerful tools in synthetic chemistry for the efficient synthesis of diverse molecular scaffolds, particularly nitrogen‐containing heterocycles. Despite their numerous advantages, use transition metal catalysts or additives MCRs can present limitations due to cost, toxicity, and environmental concerns. In recent years, there has been a growing interest metal‐free N ‐heterocyclic compounds. This review provides comprehensive concise overview advancements valuable ‐heterocycles over past five years. The is systematically organized, categorizing discussed based on size heterocyclic ring number nitrogen atoms. Only that result formation rings containing at least one atom are included, while derivatization using falls outside scope this review. By highlighting developments field, aims showcase potential significance sustainable strategies accessing elimination metals not only simplifies reaction conditions but also contributes greener more environmentally friendly approaches. serves resource researchers interested design application

Язык: Английский

---

Substrate-Controlled Regioselectivity Switchable [3 + 2] Annulations To Access Spirooxindole Skeletons

The Journal of Organic Chemistry, Год журнала: 2022, Номер 87(12), С. 8158 - 8169

Опубликована: Июнь 8, 2022

The additive-free [3 + 2] annulation from isatins, amino acids with 2-styrylbenzoxazoles, was described, providing a series of functional and structurally complex 3,3'-pyrrolidinyl-spirooxindole derivatives containing four contiguous two quaternary stereogenic centers in high yields (up to 95%) excellent diastereoselectivities >25:1 dr). Interestingly, the reaction exhibits switchable regioselectivity depending on substrate acids. With proline or thioproline as substrate, afforded α-regioselective spirooxindole skeletons. In contrast, when piperidine acid is provided γ-regioselective

Язык: Английский

---

Efficient synthesis of chromeno[2,3-b]pyridine derivatives using Zn(OTf)2 as a catalyst: DFT computations, molecular docking and ADME studies

Journal of Molecular Liquids, Год журнала: 2023, Номер 375, С. 121364 - 121364

Опубликована: Фев. 1, 2023

Язык: Английский

---

DABCO-promoted highly diastereo- and regioselective construction of C-3 functionalized spirooxindoles via [3 + 2] cycloaddition of 2-aryl/heteroarylidene-1H-indene-1,3(2H)-diones with N-2,2,2-trifluoroethylisatin ketimines at ambient conditions

RSC Advances, Год журнала: 2022, Номер 12(54), С. 34941 - 34945

Опубликована: Янв. 1, 2022

The application of 2-aryl/heteroarylidene-1H-indene-1,3(2H)-dione as an activated olefin source in the DABCO-catalyzed [3 + 2] cycloaddition with N-2,2,2-trifluoroethylisatin ketimines has been disclosed. This highly efficient 1,3-dipolar reaction offered a variety trifluoro methyl group bearing spiro-pyrrolidine linked oxindoles four consecutive stereocentres good to excellent yield and diastereoselectivity. synthetic practicality protocol was established by demonstrating enantioselective construction spiro-pyrrolidine-oxindoles two vicinal spiro-quaternary chiral centres enantioselectivity (>90% ee) using ultralow loading quinine catalyst at room temperature.

Язык: Английский

---

Theranostics: aptamer-assisted carbon nanotubes as MRI contrast and photothermal agent for breast cancer therapy

Discover Nano, Год журнала: 2024, Номер 19(1)

Опубликована: Сен. 10, 2024

Breast cancer is one of the leading causes death among women globally, making its diagnosis and treatment challenging. The use nanotechnology for an emerging area research. To address this issue, multiwalled carbon nanotubes (MWCNTs) were ligand exchanged with butyric acid (BA) to gain hydrophilic character. successful functionalization was confirmed by FTIR spectroscopy. Surface morphology changes observed using SEM, while TEM structural integrity MWCNTs after functionalization. Particle size, zeta potential, UV spectroscopy also performed further characterize nanoparticles. breast aptamer specific Mucin-1 (MUC-1) then conjugated functionalized MWCNTs. These successfully targeted cells (MDA-MB-231) as examined cellular uptake studies exhibited a reduction in cancer-induced inflammation, evidenced gene transcription (qPCR) protein expression (immunoblotting) levels. Immunoblot confocal-based immunofluorescence assay (IFA) indicated ability CNTs induce photothermal cell MDA-MB-231 cells. Upon imaging, effectively visualized due MWCNTs' act magnetic resonance imaging (MRI) contrast agents. Additionally, demonstrated capabilities eliminate bound Collectively, our findings pave way developing aptamer-labeled viable "theranostic alternatives" treatment.

Язык: Английский

---

Efficient metal-free green syntheses of 4H-chromenes and 3-amino alkylated indoles using a reusable graphite oxide carbocatalyst under aqueous and solvent-free reaction conditions

New Journal of Chemistry, Год журнала: 2022, Номер 46(24), С. 11706 - 11721

Опубликована: Янв. 1, 2022

Graphite oxide was employed as a reusable catalyst for the synthesis of 4 H -chromenes and 3-amino alkylated indoles in aqueous solvent-free reaction conditions.

Язык: Английский

---