Expert Opinion on Drug Delivery, Год журнала: 2024, Номер 21(10), С. 1441 - 1461
Опубликована: Окт. 2, 2024
Nucleic acid (NA)-based therapeutics have shown great potential for downregulating or augmenting gene expression, and promising applications,
Язык: Английский
Heliyon, Год журнала: 2023, Номер 9(6), С. e17488 - e17488
Опубликована: Июнь 1, 2023
Advances in molecular pharmacology and an improved understanding of the mechanism most diseases have created need to specifically target cells involved initiation progression diseases. This is especially true for life-threatening requiring therapeutic agents which numerous side effects, thus accurate tissue targeting minimize systemic exposure. Recent drug delivery systems (DDS) are formulated using advanced technology accelerate specific site, maximizing efficacy minimizing off-target accumulation body. As a result, they play important role disease management treatment. DDS offer greater advantages when compared conventional due their enhanced performance, automation, precision, efficacy. They made nanomaterials or miniaturized devices with multifunctional components that biocompatible, biodegradable, high viscoelasticity extended circulating half-life. review, therefore, provides comprehensive insight into history technological advancement systems. It updates recent systems, applications, challenges associated use, future directions performance use.
Язык: Английский
Процитировано
329
Drug Delivery and Translational Research, Год журнала: 2022, Номер 13(3), С. 716 - 737
Опубликована: Ноя. 22, 2022
Язык: Английский
Процитировано
115
ACS Nano, Год журнала: 2023, Номер 17(6), С. 5187 - 5210
Опубликована: Март 10, 2023
Red blood cells (RBCs) and RBC membrane-derived nanoparticles have been historically developed as bioinspired drug delivery systems to combat the issues of premature clearance, toxicity, immunogenicity synthetic nanocarriers. RBC-based possess characteristics including biocompatibility, biodegradability, long circulation time, which make them suited for systemic administration. Therefore, they employed in designing optimal formulations various preclinical models clinical trials treat a wide range diseases. In this review, we provide an overview biology, synthesis, characterization based on RBCs their membrane whole RBCs, membrane-camouflaged nanoparticles, RBC-derived extracellular vesicles, hitchhiking. We also highlight conventional latest engineering strategies, along with therapeutic modalities, enhanced precision effectiveness delivery. Additionally, focus current state applications translation carriers, well discussing opportunities challenges associated these systems.
Язык: Английский
Процитировано
98
Nano TransMed, Год журнала: 2024, Номер 3, С. 100040 - 100040
Опубликована: Июнь 27, 2024
Currently, cancer is the leading cause of death globally. In absence specific treatment and early diagnosis, procedures like surgery, chemotherapy, radiation therapy are often used to manage disease. However, these approaches fail control due inefficacy, nonspecific distribution, side effects drugs. Anticancer drugs essential in reducing cell growth helping damage those cells. severe have limited bioavailability their distribution throughout body. Therefore, development intelligent drug release systems essential. Nanoparticle delivery promising strategies improve therapeutic efficacy safety, overcoming challenges. Among systems, a natural polysaccharide called chitosan, derivative chitin, has gained considerable attention as biocompatible, biodegradable, mucoadhesive material for creating nanoparticles. Chitosan nanoparticles provide several advantages, including improved stability, cellular uptake, solubility anticancer drugs, modulation kinetics, biodistribution. Additionally, chitosan can be modified on surface with ligands or stimuli-responsive moieties achieve targeted cells tissues. This review explores recent advances chitosan-based nanoparticle delivery, efficacy, applications therapy.
Язык: Английский
Процитировано
18
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Март 20, 2024
Recent research in artificial cell production holds promise for the development of delivery agents with therapeutic effects akin to real cells. To succeed these applications, systems need survive circulatory conditions. In this review we present strategies that, inspired by endurance red blood cells, have enhanced viability large, cell-like vehicles vivo use, particularly focusing on giant unilamellar vesicles. Insights from cells can guide modifications that could transform platforms into advanced drug vehicles, showcasing biomimicry's potential shaping future applications.
Язык: Английский
Процитировано
16
Micromachines, Год журнала: 2022, Номер 13(12), С. 2091 - 2091
Опубликована: Ноя. 27, 2022
The potential use of nanomaterials in medicine offers opportunities for novel therapeutic approaches to treating complex disorders. For that reason, a new branch science, named nanotoxicology, which aims study the dangerous effects on human health and environment, has recently emerged. However, toxicity risk associated with are unclear or not completely understood. development an adequate experimental strategy assessing may include rapid/express method will reliably, quickly, cheaply make initial assessment. One possibility is characterization hemocompatibility nanomaterials, includes their hemolytic activity as marker. In this review, we consider various factors affecting draw reader’s attention fact formation protein corona around nanoparticle can significantly change its interaction red cell. This leads us suggest nanomaterial buffer does reflect situation blood plasma. As recommendation, propose studying under more physiologically relevant conditions, presence plasma proteins medium mechanical stress.
Язык: Английский
Процитировано
44
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 165, С. 115049 - 115049
Опубликована: Июнь 25, 2023
The management and treatment of disease are achieved via the use pharmacologically active substances or drugs. Drugs do not, however, have an intrinsic ability to be effective; rather, how well they work depends on administered supplied. Treatment a variety biological illnesses, such as autoimmune disorders, cancer, bacterial infections, requires effective drug delivery. Drug absorption, distribution, metabolism, duration therapeutic impact, pharmacokinetics, excretion, toxicity can all impacted by administration. Improved chemistry materials required for delivery concentration novel treatments specified targets within body, necessary time. This requirement is accompanied development new therapeutics. Formulating medication DDS promising strategy directly addressing numerous typical barriers adherence, frequent dosage, side effects, delayed beginning action. In current review, we give compendium controlled release subsequently highlight some newest developments in realm, with particular emphasis cutting-edge methods targeted therapy. each instance, outline obstacles efficient administration chemical material that allowing sector overcome these positive clinical impact.
Язык: Английский
Процитировано
22
Nanoscale, Год журнала: 2023, Номер 15(14), С. 6432 - 6455
Опубликована: Янв. 1, 2023
The incorporation of biomimetic nanoparticles into the DC vaccination strategies has shown outstanding advantages in precisely directing immune system to fight cancer.
Язык: Английский
Процитировано
17
Pharmaceutics, Год журнала: 2023, Номер 15(7), С. 1953 - 1953
Опубликована: Июль 14, 2023
Nanomedicines have made remarkable advances in recent years, addressing the limitations of traditional therapy and treatment methods. Due to their improved drug solubility, stability, precise delivery, ability target specific sites, nanoparticle-based delivery systems emerged as highly promising solutions. The successful interaction nanoparticles with biological systems, on other hand, is dependent intentional surface engineering. As a result, biomimetic been developed novel carriers. In-depth knowledge various nanoparticles, applications, methods used for formulation, emphasis microfluidic production technique, provided this review. Microfluidics has one most approaches control, high reproducibility, scalability, waste reduction, faster times preparation nanoparticles. Significant advancements personalized medicine can be achieved by harnessing benefits leveraging technology, offering enhanced functionality biocompatibility.
Язык: Английский
Процитировано
16
Nanomaterials, Год журнала: 2025, Номер 15(3), С. 187 - 187
Опубликована: Янв. 24, 2025
The use of nanoparticles is becoming increasingly apparent in a growing number medical fields. To exploit the full potential these particles, it essential to examine their behavior blood and possible interactions with cells. Dendritic core multi-shell DendroSol™ (DS-NPs) are able penetrate into viable layers human skin, but nothing known about interaction In present study, we analyze effect DS-NPs on red cells (RBCs) using confocal laser scanning microscopy (CLSM), flow cytometry, sedimentation rate analysis, spectrophotometry, hemolysis assays. labeled Nile (NR) were added RBC suspensions accumulation area membranes was demonstrated by CLSM as well cytometry. presence DS-NPs, RBCs show an increased rate, which also confirms binding NPs Interestingly, stabilized against hypotonic hemolytic action Triton X-100. This proven anti-hemolytic could be utilized enhance circulation time loaded drugs for prolonged sustained release drug delivery enhanced bioavailability.
Язык: Английский
Процитировано
0