The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(21), С. 15901 - 15913

Опубликована: Окт. 12, 2024

A novel and robust alkynylation of C(sp3)–H bonds adjacent to a nitrogen atom tertiary amines with alkynyl bromides as radical alkynylating reagents has been realized under visible-light irradiation. range variety including N-arylamines N-alkylamine have coupled both aromatic aliphatic furnish 51 examples propargylamines in moderate excellent yields (31–80% yields). The possible mechanism was addition–elimination process based on preliminary mechanistic studies.

Язык: Английский