Brain-Gut-Microbiota Axis in Alzheimer’s Disease

Journal of Neurogastroenterology and Motility, Год журнала: 2019, Номер 25(1), С. 48 - 60

Опубликована: Янв. 10, 2019

Disturbances along the brain-gut-microbiota axis may significantly contribute to pathogenesis of neurodegenerative disorders. Alzheimer's disease (AD) is most frequent cause dementia characterized by a progressive decline in cognitive function associated with formation amyloid beta (Aβ) plaques and neurofibrillary tangles. Alterations gut microbiota composition induce increased permeability barrier immune activation leading systemic inflammation, which turn impair blood-brain promote neuroinflammation, neural injury, ultimately neurodegeneration. Recently, Aβ has also been recognized as an antimicrobial peptide participating innate response. However, dysregulated state, reveal harmful properties. Importantly, bacterial amyloids through molecular mimicry elicit cross-seeding misfolding microglial priming. The seeding propagation occur at different levels axis. potential mechanisms spreading include neuron-to-neuron or distal neuron spreading, direct crossing via other cells astrocytes, fibroblasts, microglia, system cells. A growing body experimental clinical data confirms key role dysbiosis microbiota-host interactions convergence gut-derived inflammatory response together aging poor diet elderly AD. Modification food-based therapy probiotic supplementation create new preventive therapeutic options

Язык: Английский

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Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(10), С. 2534 - 2534

Опубликована: Май 23, 2019

Nowadays, the oral use of probiotics is widespread. However, safety profile with live still a matter debate. Main risks include: Cases systemic infections due to translocation, particularly in vulnerable patients and pediatric populations; acquisition antibiotic resistance genes; or interference gut colonization neonates. To avoid these risks, there an increasing interest non-viable microorganisms microbial cell extracts be used as probiotics, mainly heat-killed (including tyndallized) probiotic bacteria (lactic acid bifidobacteria). Heat-treated cells, cell-free supernatants, purified key components are able confer beneficial effects, immunomodulatory protection against enteropathogens, maintenance intestinal barrier integrity. At clinical level, products containing tyndallized strains have had role gastrointestinal diseases, including bloating infantile coli—in combination mucosal protectors—and diarrhea. Heat-inactivated could also management dermatological respiratory allergic diseases. The reviewed data indicate that their fractions advantages versus (mainly profile), positioning them interesting strategies for common prevalent conditions wide variety patients´ characteristics.

Язык: Английский

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Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease

Journal of Neuroinflammation, Год журнала: 2018, Номер 15(1)

Опубликована: Сен. 24, 2018

Alzheimer’s disease (AD) is a neurodegenerative disorder, most cases of which lack clear causative event. This has made the difficult to characterize and, thus, diagnose. Although some are genetically linked, there many diseases and lifestyle factors that can lead an increased risk developing AD, including traumatic brain injury, diabetes, hypertension, obesity, other metabolic syndromes, in addition aging. Identifying common trends between these conditions could enhance our understanding AD development more effective treatments. immune system one body’s key defense mechanisms, chronic inflammation been increasingly linked with several age-related diseases. Moreover, it now well accepted important role onset progression AD. In this review, different inflammatory signals associated its will be outlined demonstrate how may influencing individual susceptibility Our goal bring attention potential shared presented by during successful

Язык: Английский

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Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(9), С. 2293 - 2293

Опубликована: Май 9, 2019

A large body of experimental evidence suggests that neuroinflammation is a key pathological event triggering and perpetuating the neurodegenerative process associated with many neurological diseases. Therefore, different stimuli, such as lipopolysaccharide (LPS), are used to model neurodegeneration. By acting at its receptors, LPS activates various intracellular molecules, which alter expression plethora inflammatory mediators. These factors, in turn, initiate or contribute development processes. an important tool for study However, serotype, route administration, number injections this toxin induce varied responses. Thus, here, we review use models neurodegeneration well discuss neuroinflammatory mechanisms induced by could underpin events linked process.

Язык: Английский

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The endotoxin hypothesis of neurodegeneration

Journal of Neuroinflammation, Год журнала: 2019, Номер 16(1)

Опубликована: Сен. 13, 2019

The endotoxin hypothesis of neurodegeneration is the that causes or contributes to neurodegeneration. Endotoxin a lipopolysaccharide (LPS), constituting much outer membrane gram-negative bacteria, present at high concentrations in gut, gums and skin other tissue during bacterial infection. Blood plasma levels are normally low, but elevated infections, gut inflammation, gum disease neurodegenerative disease. Adding such blood healthy humans induces systemic inflammation brain microglial activation. body rodents activation, priming and/or tolerance, memory deficits loss synapses neurons. promotes amyloid β tau aggregation neuropathology, suggesting possibility synergises with different aggregable proteins give diseases. Alzheimer's disease, which accelerated by including binds directly APOE, APOE4 variant both sensitises predisposes Intestinal permeability increases early Parkinson's injection into mice α-synuclein production aggregation, as well dopaminergic neurons substantia nigra. microbiome changes changing endotoxin-producing species can affect patients mouse models. amyotrophic lateral sclerosis, TDP-43 neuropathology. Peripheral diseases elevate endotoxin, sepsis, AIDS liver failure, also result indirectly activates microglia damage via nitric oxide, oxidants cytokines, phagocytosis unproven, if correct, then may be reduced decreasing endotoxin-induced neuroinflammation.

Язык: Английский

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Antibiotics, gut microbiota, and Alzheimer’s disease

Journal of Neuroinflammation, Год журнала: 2019, Номер 16(1)

Опубликована: Май 22, 2019

Alzheimer's disease (AD) is a neurodegenerative whose various pathophysiological aspects are still being investigated. Recently, it has been hypothesized that AD may be associated with dysbiosis of microbes in the intestine. In fact, intestinal flora able to influence activity brain and cause its dysfunctions.Given growing interest this topic, purpose review analyze role antibiotics relation gut microbiota AD. first part review, we briefly theories supporting hypothesis can pathophysiology. second part, possible these events. Antibiotics normally used remove or prevent bacterial colonization human body, without targeting specific types bacteria. As result, broad-spectrum greatly affect composition microbiota, reduce biodiversity, delay for long period after administration. Thus, action could wide even opposite, depending on type antibiotic microbiome pathogenesis.Alteration induce changes activity, which raise possibility therapeutic manipulation other neurological disorders. This field research currently undergoing great development, but applications far away. Whether achieved using not known. The future depends progresses We must understand how when bacteria act promote Once well established, one think modifications use pre-, pro-, produce effects.

Язык: Английский

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Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer’s disease

Inflammopharmacology, Год журнала: 2019, Номер 27(4), С. 663 - 677

Опубликована: Март 14, 2019

Язык: Английский

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Role of gut-brain axis, gut microbial composition, and probiotic intervention in Alzheimer's disease

Life Sciences, Год журнала: 2020, Номер 264, С. 118627 - 118627

Опубликована: Окт. 22, 2020

Язык: Английский

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Gut Microbiota and Dysbiosis in Alzheimer’s Disease: Implications for Pathogenesis and Treatment

Molecular Neurobiology, Год журнала: 2020, Номер 57(12), С. 5026 - 5043

Опубликована: Авг. 22, 2020

Understanding how gut flora influences gut-brain communications has been the subject of significant research over past decade. The broadening term "microbiota-gut-brain axis" from "gut-brain underscores a bidirectional communication system between and brain. microbiota-gut-brain axis involves metabolic, endocrine, neural, immune pathways which are crucial for maintenance brain homeostasis. Alterations in composition microbiota associated with multiple neuropsychiatric disorders. Although causal relationship dysbiosis neural dysfunction remains elusive, emerging evidence indicates that may promote amyloid-beta aggregation, neuroinflammation, oxidative stress, insulin resistance pathogenesis Alzheimer's disease (AD). Illustration mechanisms underlying regulation by pave way developing novel therapeutic strategies AD. In this narrative review, we provide an overview their dysregulation Novel insights into modification as preventive or approach AD highlighted.

Язык: Английский

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Fecal Microbiota Transplantation in Neurological Disorders

Frontiers in Cellular and Infection Microbiology, Год журнала: 2020, Номер 10

Опубликована: Март 24, 2020

Background Several studies suggested an important role of the gut microbiota in pathophysiology neurological disorders, implying that alteration might serve as a treatment strategy. Fecal transplantation (FMT) is currently most effective intervention and accepted for recurrent Clostridioioides difficile infections. To evaluate indications FMT patients with we summarized available literature on FMT. In addition, provide suggestions future directions. Methods July 2019, five main databases were searched case descriptions disorders humans or animal models. ClinicalTrials.gov website was consulted registered planned ongoing trials. Results Of 541 identified studies, 34 included analysis. Clinical trials have been performed autism spectrum disorder showed beneficial effects symptoms. For multiple sclerosis Parkinson's disease, several positive effect FMT, supported by some reports humans. epilepsy, Tourette syndrome, diabetic neuropathy but evidence restricted to limited numbers studies. stroke, Alzheimer's disease Guillain-Barré syndrome only models identified. These potential healthy donor contrast, one study model stroke increased mortality after Whether findings from can be confirmed human diseases awaits seen. above mentioned are ongoing, well amyotrophic lateral sclerosis. Conclusions Preliminary suggests may promising option disorders. However, still scanty contrasting results observed. Limited while experiments conducted. Large double-blinded randomized controlled needed further elucidate

Язык: Английский

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