Association of Gut Microbiota with Inflammatory Bowel Disease and COVID-19 Severity: A Possible Outcome of the Altered Immune Response

Current Microbiology, Год журнала: 2022, Номер 79(6)

Опубликована: Май 5, 2022

Язык: Английский

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Predictive model for bacterial co-infection in patients hospitalized for COVID-19: a multicenter observational cohort study

Infection, Год журнала: 2022, Номер 50(5), С. 1243 - 1253

Опубликована: Апрель 29, 2022

Abstract Objective The aim of our study was to build a predictive model able stratify the risk bacterial co-infection at hospitalization in patients with COVID-19. Methods Multicenter observational adult hospitalized from February December 2020 confirmed COVID-19 diagnosis. Endpoint microbiologically documented diagnosed within 72 h hospitalization. cohort randomly split into derivation and validation cohort. To investigate factors for univariable multivariable logistic regression analyses were performed. Predictive score obtained assigning point value corresponding β-coefficients variables model. ROC analysis used estimate prediction accuracy. Results Overall, 1733 analyzed: 61.4% males, median age 69 years (IQR 57–80), Charlson 3 2–6). Co-infection 110 (6.3%) patients. Empirical antibiotics started 64.2 59.5% without ( p = 0.35). At cohort: WBC ≥ 7.7/mm , PCT 0.2 ng/mL, index 5 co-infection. A assigned each variable obtaining ranging 0 5. In cohort, showed AUC 0.83 (95%CI 0.75–0.90). optimal cut-point ≥2 sensitivity 70.0%, specificity 75.9%, positive 16.0% negative 97.5%. According individual score, classified low (point 0), intermediate 1), high 2). CURB-65 2 further proposed identify who would benefit early antibiotic coverage. Conclusions Our may be useful stratifying patients, optimizing diagnostic testing use.

Язык: Английский

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Dysbiosis of gut microbiota in patients with severe COVID‐19

Acute Medicine & Surgery, Год журнала: 2024, Номер 11(1)

Опубликована: Янв. 1, 2024

Altered gut microbiota has been proposed as one of the causes exacerbation severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19) from perspective gut-lung axis. We aimed to evaluate in mechanically ventilated patients with COVID-19 prior using antibiotics.

Язык: Английский

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Role of Micronutrients and Gut Microbiota-Derived Metabolites in COVID-19 Recovery

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(20), С. 12324 - 12324

Опубликована: Окт. 14, 2022

A balanced and varied diet provides diverse beneficial effects on health, such as adequate micronutrient availability a gut microbiome in homeostasis. Besides their participation biochemical processes cofactors coenzymes, vitamins minerals have an immunoregulatory function; meanwhile, microbiota its metabolites coordinate directly indirectly the cell response through interaction with host receptors. Malnourishment is crucial risk factor for several pathologies, involvement during Coronavirus Disease 2019 pandemic has been reported. This caused significant decline worldwide population, especially those chronic diseases, reduced physical activity, elder age. Diet composition are probable causes this susceptibility, supplementation can play role reestablishing microbial homeostasis improving immunity against infection recovery. study reviews of micronutrients microbiomes infection, severity disease, sequelae.

Язык: Английский

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Impact of COVID-19 and Antibiotic Treatments on Gut Microbiome: A Role for Enterococcus spp.

Biomedicines, Год журнала: 2022, Номер 10(11), С. 2786 - 2786

Опубликована: Ноя. 2, 2022

Several studies showed the substantial use of antibiotics and increased risk antimicrobial resistant infections in patients with COVID-19. The impact COVID-19-related treatments on gut dysbiosis has not been clarified.The prospective cohort study included hospitalized COVID-19 (April-December 2020). microbiome composition was analysed by 16S sequencing. diversity changes opportunistic bacteria (OBs) or symbionts were according to clinical parameters, laboratory markers disease progression, type non-antibiotic (NACT) type, WHO AWaRe group, duration antibiotic therapy (AT).A total 82 (mean age 66 ± 13 years, 70% males) enrolled. relative abundance Enterococcus significantly correlated hospitalization, intensive care unit stay, O2 needs, D-dimer, ferritin, IL-6 blood levels. presence highest number correlations NACT, AT, AT + NACT (e.g., hydroxychloroquine lopinavir/ritonavir) Watch/Reserve antibiotics, duration, combinations. Abundance Dorea, Agathobacter, Roseburia, Barnesiella negatively corticosteroids use. Patients IL-6, ferritin levels receiving more likely show Bilophila decreased Roseburia compared those AT.Microbiome is affected severity. In this context, treatment may shift towards OBs, particularly Enterococcus. treatment-driven OBs long-term consequences needs further define role homeostasis recovery inform targeted interventions.

Язык: Английский

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