SARS-CoV-2 nucleocapsid protein induces a Mincle-dependent macrophage inflammatory response in acute kidney injury

Inflammation Research, Год журнала: 2025, Номер 74(1)

Опубликована: Апрель 17, 2025

Язык: Английский

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Long-Term Radiological Pulmonary Changes in Mechanically Ventilated Patients with Respiratory Failure due to SARS-CoV-2 Infection

Biomedicines, Год журнала: 2023, Номер 11(10), С. 2637 - 2637

Опубликована: Сен. 26, 2023

From the first reports of SARS-CoV-2, at end 2019 to present, global mortality associated with COVID-19 has reached 6,952,522 deaths as reported by World Health Organization (WHO). Early intubation and mechanical ventilation can increase survival rate critically ill patients. This prospective study was carried out on 885 patients in ICU Mureș County Clinical Hospital, Romania. After applying inclusion exclusion criteria, a total 54 were included. Patients monitored during hospitalization 6-month follow-up. We analyzed relationship between invasive (IMV) non-invasive (NIMV) radiological changes thoracic CT scans performed follow-up found no significant association. Regarding paraclinical analysis, there statistically association grouped IMV ferritin level day 1 admission (p = 0.034), PaO2/FiO2 ratio metabolic syndrome 0.03) procalcitonin 0.01). A proportion admitted developed pulmonary fibrosis observed evaluation. oxygen supplementation or require dynamic monitoring investigations, is possibility long-term that requires pharmacological interventions finding new therapeutic alternatives.

Язык: Английский

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COVID-19 and Kidney: The Importance of Follow-Up and Long-Term Screening

Life, Год журнала: 2023, Номер 13(11), С. 2137 - 2137

Опубликована: Окт. 30, 2023

Renal involvement and kidney injury are common in COVID-19 patients, the symptoms more severe if patient already has renal impairment. is multifactorial, tubule mainly affected, along with podocyte during SARS-CoV-2 infection. Inflammation, complement activation, hypercoagulation, crosstalk between lungs, brain, heart contributory factors. Kidney acute phase, termed (AKI), may proceed to chronic disease discharged Both AKI (CKD) increase mortality patients. Further, infection patients suffering from CKD increases rate. Thus, it important address both categories of either developing or after previously having CKD, proper management treatment. This review discusses pathophysiology involved infection, followed by treatment CKD. a discussion importance screening infected future perspectives improve such

Язык: Английский

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Kidney Disease and Proteomics: A Recent Overview of a Useful Tool for Improving Early Diagnosis

Advances in experimental medicine and biology, Год журнала: 2024, Номер unknown, С. 173 - 186

Опубликована: Янв. 1, 2024

Язык: Английский

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COVID‐19 and preeclampsia: The unique and the mutually nonexclusive clinical manifestations

American Journal of Reproductive Immunology, Год журнала: 2023, Номер 89(5)

Опубликована: Март 30, 2023

Abstract Preeclampsia (PE) is a serious, unpredictable hypertensive disorder of pregnancy present in around 8–10% all pregnancies resulting high rate maternal and fetal morbidity mortality. With the pathophysiology partially known, delivery only cure for PE. The disease sets due to multiple pathologic processes involving endothelial cell activation, inflammation, multiorgan damage syncytiotrophoblast stress. Though primary target organ lungs COVID‐19, other systemic manifestations which include dysfunction, dysregulated angiogenesis, thrombosis, liver injury, thrombocytopenia, hypertension kidney overlap with COVID‐19 patients show higher incidence PE as compared their noninfected counterparts vice versa. Similar clinical features make differential diagnosis challenging. For effective specific management, it important differentiate actual from like features. There are contradictory reports about accuracy diagnostic tools distinguishing severe available data, can be stated that common adverse event, may exacerbated by, or exacerbate, COVID‐19. Future research should focus on cohesive understanding manifestations, preventive strategies during pregnancy.

Язык: Английский

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MDM2 Influences ACE2 Stability and SARS-CoV-2 Uptake

Viruses, Год журнала: 2023, Номер 15(8), С. 1763 - 1763

Опубликована: Авг. 18, 2023

Angiotensin-converting enzyme 2 (ACE2) is the central entry receptor for SARS-CoV-2. However, surprisingly little known about effects of host regulators on ACE2 localization, expression, and associated influence SARS-CoV-2 infection. Here we identify that expression levels are regulated by E3 ligase MDM2 indirectly infection with Genetic depletion elevated levels, which strongly promoted all isolates tested. spike-pseudotyped viruses uptake non-replication-competent virus-like particles showed affects viral process. ubiquitinates Lysine 788 to induce proteasomal degradation, degradation this residue led higher superior virus particle uptake. Our study illustrates cellular stability, such as MDM2, play an important role in defining capabilities

Язык: Английский

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COVID-19 Infection in Chronic Kidney Disease Patients in Bulgaria: Risk Factors for Death and Acute Kidney Injury

Journal of Personalized Medicine, Год журнала: 2022, Номер 12(10), С. 1676 - 1676

Опубликована: Окт. 9, 2022

Regarding COVID-19 infection, Bulgaria has one of the lowest rates vaccination in Europe, and its COVID-19-related mortality rate been highest European Union. Chronic kidney disease (CKD)-COVID-19 patients are at higher risk developing acute injury (AKI) death after hospital admission. This single-center prospective cohort study from included 120 in-patient subjects whom 70 had CKD 50 normal renal function. Diabetes mellitus, hypertension, obesity, cardiovascular were statistically more prevalent group as compared to non-CKD group. At admission, D-dimer, creatinine, urea levels significantly group, whereas estimated glomerular-filtration was lower patients. During hospitalization, 23 (19.1%) died, which 19 (p-value = 0.0096); addition, 38 developed AKI (31.6%), 31 0.0006). Using binary logistic regression, being male, having experienced AKI, not treated with remdesivir independent factors for COVID-19-induced mortality. symptoms than 6 days before baseline, received therapy predictive

Язык: Английский

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Prognostic significance of early acute kidney injury in COVID-19 patients requiring mechanical ventilation: a single-center retrospective analysis

Renal Failure, Год журнала: 2023, Номер 45(1)

Опубликована: Май 3, 2023

Acute kidney injury (AKI) is associated with impaired outcomes in critically ill COVID-19 patients. However, the prognostic significance of early AKI poorly described. We aimed to determine whether on admission intensive care unit (ICU) and its development within first 48 h predict need for renal replacement therapy (RRT) increased mortality. An analysis 372 patients pneumonia requiring mechanical ventilation without advanced chronic disease from 2020 2021 was performed. The stages ICU Day 2 were determined using adapted KDIGO criteria. function assessed by change score Day-2/Day-0 creatinine ratio. Data compared between three consecutive waves data before pandemic. Both 90-day mortality (79% 93% vs. 35% 44%) RRT markedly stage admission. Similarly, an increase implied highly very high (72% 85%), even surpassing that ECMO. No difference found waves, except a lower last omicron wave. Mortality comparable pre-COVID-19 patients, did not era. In conclusion, we confirmed both severe pneumonia.

Язык: Английский

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The Diverse Nature of the Molecular Interactions That Govern the COV-2 Variants’ Cell Receptor Affinity Ranking and Its Experimental Variability

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2585 - 2585

Опубликована: Фев. 23, 2024

A critical determinant of infectivity and virulence the most infectious or lethal variants concern (VOCs): Wild Type, Delta Omicron is related to binding interactions between receptor-binding domain spike its host receptor, initial step in cell infection. It utmost importance understand how mutations a viral strain, especially those that are spike, affect resulting emerging VOC, knowledge could help us variant inform therapies applied vaccines developed. For this sake, we have battery computational protocols increasing complexity calculation affinity for three ACE2 receptor. The results clearly illustrate attachment spikes receptor originates through different molecular interaction mechanisms. All our unanimously predict has highest affinity, while displays substantial variability relates structural plasticity spike-receptor complex. We suggest latter result explain (at least part) vitro VOC led reason lower as compared earlier strains. Several hypotheses been developed around subject.

Язык: Английский

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Clinical characteristics and prognosis of patients with COVID-19 on mechanical ventilation undergoing continuous renal replacement therapy

PLoS ONE, Год журнала: 2024, Номер 19(4), С. e0297344 - e0297344

Опубликована: Апрель 3, 2024

Background The coronavirus disease (COVID-19) pandemic has significantly strained global healthcare, particularly in the management of patients requiring mechanical ventilation (MV) and continuous renal replacement therapy (CRRT). This study investigated characteristics prognoses these patients. Methods multicenter retrospective cohort gathered data from with COVID-19 across 26 medical centers. Logistic analysis was used to identify factors associated CRRT implementation. Results Of 640 who required MV, 123 (19.2%) underwent CRRT. Compared non-CRRT group, group older exhibited higher sequential organ failure assessment scores. incidence hypertension, diabetes, cardiovascular disease, chronic neurological kidney also group. Moreover, had intensive care unit (ICU) (75.6% vs. 26.9%, p < 0.001) in-hospital (79.7% 29.6%, mortality rates. implementation identified as an independent risk factor for both ICU (hazard ratio [HR]:1.833, 95% confidence interval [CI]:1.342–2.505, (HR: 2.228, CI: 1.648–3.014, 0.001). Refractory respiratory (n = 99, 19.1%) most common cause death shock multi-organ 50, 40.7%) Shock cardiac were more compared Conclusion indicates that is rates require MV. Notably, primary failure, emphasizing severe clinical course patients, while refractory

Язык: Английский

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