Frontiers in Pediatrics,
Год журнала:
2023,
Номер
11
Опубликована: Фев. 9, 2023
Aim
We
aimed
to
investigate
the
seroprevalence
of
Epstein–Barr
virus
(EBV)
infection
in
children
before
and
during
COVID-19
pandemic.
Methods
All
admitted
Children's
Hospital
Affiliated
Zhejiang
University
from
January
2019
December
2021
with
suspected
EBV-associated
disease
EBV
antibodies
were
detected
by
a
two-step
indirect
method
chemiluminescence
technology.
A
total
44,943
enrolled
this
study.
The
infections
was
compared
2021.
Results
seropositive
rate
61.02%
between
2021,
trend
decreased
year
year.
number
2020
reduced
30%
that
2019.
In
particular,
nearly
50%
reductions
acute
reactivations
or
late
primary
found,
respectively.
aged
1–3
years
reactivation
6–9
sharply
dropped
approximately
40%
64%
Conclusions
Our
study
further
demonstrated
prevention
control
measures
for
China
had
certain
effect
on
containing
infections.
Microbiology Spectrum,
Год журнала:
2024,
Номер
12(5)
Опубликована: Апрель 12, 2024
Mycoplasma
pneumoniae
(MP)
is
commonly
detected
in
children.
However,
the
epidemiological
trends
of
MP
Northeast
(NE)
China
are
unclear.
This
retrospective
study
aimed
to
investigate
prevalence
infections
this
understudied
region.
The
clinical
manifestations
and
bronchoscopic
findings
observed
hospitalized
patients
with
severe
pneumonia
(SMPP)
were
collected
from
comprehensive
data
obtained
six
tertiary
hospitals
NE
Inner
Mongolian
(IM)
China,
1
January
2017
31
December
2023.
A
total
5,593,530
children
who
visited
outpatient
emergency
departments,
412,480
inpatient
included
study.
positivity
rate
immunoglobulin
M
(IgM)
departments
varied
7.80%
10.12%,
whereas
that
infection
ranged
27.18%
30.10%.
Children
for
mainly
concentrated
1-
4-year
(41.39%)
4-
7-year
(24.25%)
age
groups.
Before
2020,
season
highest
incidence
was
winter.
After
implementation
non-pharmaceutical
interventions
(NPIs),
epidemic
changed,
number
decreased;
however,
proportion
did
not
change
significantly.
Starting
August
2023,
outpatient,
emergency,
increased
sharply,
SMPP
its
complications
(e.g.,
plastic
bronchitis
pleural
effusion)
increasing
prevalent
IM,
China.
When
NPIs
ended,
showed
a
delayed
outbreak
trend,
In
Northeastern
Mongolia
(IM),
infections,
including
(SMPP),
high,
posing
health
risks
imposing
substantial
economic
burdens
on
local
population.
Therefore,
it
imperative
prioritize
address
research
gaps
epidemiology
these
areas
We
collection
pediatric
public
Grade
III
hospitals.
believe
our
makes
significant
contribution
literature
because
understanding
regional
variations
can
help
healthcare
professionals
tailor
prevention
treatment
strategies,
studying
provide
insights
into
impact
disease
respiratory
system,
potentially
leading
more
effective
management.
The Italian Journal of Pediatrics/Italian journal of pediatrics,
Год журнала:
2025,
Номер
51(1)
Опубликована: Янв. 23, 2025
This
study
aimed
to
describe
the
epidemiological
trends
of
Mycoplasma
pneumoniae
(MP)
infection
among
children
with
acute
respiratory
tract
infections
(ARTIs)
before,
during
and
after
COVID-19
pandemic,
evaluating
impact
non-pharmaceutical
interventions
(NPIs)
on
epidemiology
MP
infection.
Children
ARTIs
admitted
Children's
Hospital
Soochow
University
(SCH)
from
January
2010
December
2023
underwent
nucleic
acid
PCR
assay
were
included.
Clinical
data
age,
sex,
onset
time
detection
result
collected
analyzed.
All
122,984
inpatients
enrolled,
in
which
20.8%
(25659/122984)
tested
positive,
including
19.4%
(14139/72662)
for
male
22.9%
(11520/50322)
female.
It
was
a
statistically
significant
difference
between
two
genders
(p
<
0.05).
In
addition,
positive
rate
highest
age
group
>
6
years
old
each
year
During
14-year
period,
has
experienced
four
peaks
2012,
2013,
2019,
2023.
Before
NPIs
prevalence
showed
seasonality,
number
positivity
reached
their
peak
August.
However,
remained
at
low
level
NPIs.
After
abolition
NPIs,
obviously
increased
high
level.
The
could
reduce
spread
change
its
epidemic
season,
but
it
not
changed
susceptible
population
BMC Infectious Diseases,
Год журнала:
2024,
Номер
24(1)
Опубликована: Июнь 1, 2024
Abstract
Background
Nonpharmaceutical
interventions
(NPIs)
implemented
to
reduce
the
transmission
of
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
have
suppressed
spread
other
viruses
during
disease
2019
(COVID-19)
pandemic.
This
study
aimed
explore
epidemiological
trends
and
clinical
characteristics
Mycoplasma
pneumoniae
(MP)
infection
among
inpatient
children
with
lower
tract
(LRTI)
before
COVID-19
pandemic,
investigate
long-term
effects
China’s
NPIs
against
on
epidemiology
MP
LRTI.
Methods
Children
hospitalised
for
LRTI
at
Department
Pulmonology,
The
Children’s
Hospital,
Zhejiang
University
School
Medicine
(Hangzhou,
China)
between
January
December
2022
were
tested
common
pathogens,
including
(MP),
Chlamydia
trachomatis
(CT)
bacteria.
Clinical
data
age,
sex,
season
onset,
spectrum,
combined
in
MP-induced
past
4
years
collected
analysed.
Results
Overall,
15909
patients
enrolled,
MP-positive
cases
1971
(34.0%),
73
(2.4%),
176
(5.8%),
952
(20.6%)
2019,
2020,
2021,
2022,
respectively,
a
significant
statistical
difference
rate
over
(
p
<0.001).
median
age
these
was
preschool
(3–6
years),
except
when
they
school
(7–12
differences.
Comparing
positive
rates
different
groups,
school-age
years)
had
highest
rate,
followed
by
preschoolers
each
years.
Compared
seasons,
higher
summer
autumn,
whereas
it
spring.
monthly
peaked
July
remained
low
from
2020
rebounded
until
2022.
Regarding
pneumonia
accounted
proportion
(46.3%)
pre-pandemic
lowest
(0%)
2020.
Conclusion
Trends
detection
LRTIs
suggest
possible
correlation
significantly
reduced
rates.
positivity
gradually
rose
after
epidemic
showed
some
differences,
but
more
susceptible
PLoS ONE,
Год журнала:
2022,
Номер
17(9), С. e0274910 - e0274910
Опубликована: Сен. 20, 2022
It
is
well
known
that
the
presence
of
comorbidities
and
age-related
health
issues
may
hide
biochemical
metabolic
features
triggered
by
SARS-CoV-2
infection
other
diseases
associated
to
hypoxia,
as
they
are
themselves
chronic
inflammatory
conditions
potentially
disturb
homeostasis
thereby
negatively
impact
on
COVID-19
progression.
To
unveil
abnormalities
inherent
hypoxemia
caused
COVID-19,
we
here
applied
gas
chromatography
coupled
mass
spectrometry
analyze
main
changes
exhibited
a
population
male
patients
less
than
50
years
age
with
mild/moderate
severe
without
pre-existing
predispose
life-threatening
complications
from
this
infection.
Several
differences
in
serum
levels
particular
metabolites
between
normal
controls
were
identified.
These
included
increased
glutamic
acid
reduced
glutamine,
cystine,
threonic
acid,
proline
levels.
In
particular,
using
entire
metabolomic
fingerprint
obtained,
observed
glutamine/glutamate
metabolism
was
disease
severity
group
presented
lowest
higher
these
amino
acids,
respectively.
data
highlight
hypoxia-derived
alterations
provoked
absence
co-morbidities
value
determining
reactive
oxygen
species
recycling
pathways,
which
when
impaired
lead
oxidation
proteins
cell
damage.
They
also
provide
insights
new
supportive
therapies
for
disorders
involve
altered
redox
lower
better
outcomes
severity.
Multifaceted
non-pharmaceutical
interventions
during
the
COVID-19
pandemic
have
not
only
reduced
transmission
of
SARS-CoV2,
but
had
an
effect
on
prevalence
other
pathogens.
This
retrospective
study
aimed
to
compare
and
analyze
changes
respiratory
pathogens
in
hospitalized
children
with
community-acquired
pneumonia.From
January
2019
December
2020,
pneumonia
were
selected
from
Department
Respiratory
Medicine,
Shanghai
Children's
Medical
Center.
On
first
day
hospitalization,
sputum,
throat
swabs,
venous
blood
samples
them
collected
for
detection
pathogens.A
total
2596
enrolled,
including
1871
patients
725
2020.
The
rate
2020
was
lower
than
2019,
whether
single
or
multiple
Compared
virus,
especially
parainfluenza
influenza
virus
syncytial
all
decreased
contrary,
human
rhinovirus
much
higher
that
2019.
In
addition,
positivity
bacteria
did
change
over
two
years,
which
seemed
be
less
affected
by
COVID-19.
And
Mycoplasma
pneumoniae
broke
out
has
been
low
since
March
even
following
reopening
school.Strict
public
health
China
effectively
suppressed
spread
SARS-CoV2
as
well.
However,
it
a
more
limited
rhinovirus.
Therefore,
epidemiological
surveillance
will
help
improve
early
preventive
measures.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 14, 2024
Abstract
Respiratory
disorders
are
among
the
conditions
that
affect
respiratory
system.
The
healthcare
sector
faces
challenges
due
to
emergence
of
drug
resistance
prescribed
medications
for
these
illnesses.
However,
there
is
a
technology
called
CRISPR/Cas9,
which
uses
RNA
guide
DNA
targeting.
This
has
revolutionized
our
ability
manipulate
and
visualize
genome,
leading
advancements
in
research
treatment
development.
It
can
effectively
reverse
epigenetic
alterations
contribute
resistance.
Some
studies
focused
on
health
have
shown
targeting
genes
using
CRISPR/Cas9
be
challenging
when
it
comes
reducing
patients
with
disorders.
Nevertheless,
important
acknowledge
limitations
this
technology,
such
as
off-target
effects,
immune
system
reactions
Cas9,
associated
delivery
methods.
Despite
limitations,
review
aims
provide
knowledge
about
genome
editing
tools
explore
how
they
help
overcome
Additionally,
study
discusses
concerns
related
applications
CRISPR
provides
an
overview
successful
clinical
trial
studies.
