Emerging contaminants: A One Health perspective

The Innovation, Год журнала: 2024, Номер 5(4), С. 100612 - 100612

Опубликована: Март 13, 2024

Язык: Английский

---

Exploring synthesis and applications of green nanoparticles and the role of nanotechnology in wastewater treatment

Biotechnology Reports, Год журнала: 2024, Номер 41, С. e00830 - e00830

Опубликована: Янв. 26, 2024

Current research endeavours are progressively focussing towards discovering sustainable methods for synthesising eco-friendly materials. In this environment, nanotechnology has emerged as a key frontier, especially in bioremediation and biotechnology. A few areas of including membrane technology, sophisticated oxidation processes, biosensors. It is possible to create nanoparticles (NPs) via physical, chemical, or biological pathways variety sizes forms. These days, the investigation plants substitutes NP synthesis drawn lot interest. Toxic water contaminants such methyl blue have been shown be removed upto 70% by nanoparticles. our article, we aimed at environmental sustainability cost-effectiveness green Furthermore it offers comprehensive thorough summary which can distinguished their ease use, financial sustainability, environmentally favourable utilisation plant extracts. This study highlights how potential transform manufacturing NPs while adhering stewardship principles resource efficiency.

Язык: Английский

---

Identification of Natural Lead Compounds against Hemagglutinin-Esterase Surface Glycoprotein in Human Coronaviruses Investigated via MD Simulation, Principal Component Analysis, Cross-Correlation, H-Bond Plot and MMGBSA

Biomedicines, Год журнала: 2023, Номер 11(3), С. 793 - 793

Опубликована: Март 6, 2023

The pandemic outbreak of human coronavirus is a global health concern that affects people all ages and genders, but there currently still no effective, approved potential drug against coronavirus, as many other vaccines have serious side effects while the development small antiviral inhibitors has gained tremendous attention. For this research, HE was used therapeutic target, spike protein displays high binding affinity for both host ACE2 viral glycoprotein. Molecular docking, pharmacophore modelling virtual screening 38,000 natural compounds were employed to find out best inhibitor coronaviruses with more efficiency fewer further evaluated via MD simulation, PCA, DCCR MMGBSA. lead compound 'Calceolarioside B' identified on basis pharmacophoric features which depict favorable (ΔGbind -37.6799 kcal/mol) HE(5N11) receptor describes positive correlation movements in active site residues better stability, robust H-bond network, compactness reliable ADMET properties. Fraxinus sieboldiana Blume plant containing Calceolarioside B could be shows higher efficacy potency effects. This research work will aid investigators testing identification chemicals are effective useful coronavirus.

Язык: Английский

---

Wastewater surveillance for viral pathogens: A tool for public health

Heliyon, Год журнала: 2024, Номер 10(13), С. e33873 - e33873

Опубликована: Июнь 29, 2024

A focus on water quality has intensified globally, considering its critical role in sustaining life and ecosystems. Wastewater, reflecting societal development, profoundly impacts public health. Wastewater-based epidemiology (WBE) emerged as a surveillance tool for detecting outbreaks early, monitoring infectious disease trends, providing real-time insights, particularly vulnerable communities. WBE aids tracking pathogens, including viruses, sewage, offering comprehensive understanding of community health lifestyle habits. With the rise global COVID-19 cases, gained prominence, aiding SARS-CoV-2 levels worldwide. Despite advancements treatment, poorly treated wastewater discharge remains threat, amplifying spread water-, sanitation-, hygiene (WaSH)-related diseases. WBE, serving complementary surveillance, is pivotal community-level viral infections. However, there untapped potential to expand surveillance. This review emphasizes importance link between health, highlighting need further integration into management.

Язык: Английский

---

Estimates of SARS-CoV-2 Infections and Population Immunity After the COVID-19 Pandemic in Austria: Analysis of National Wastewater Data

The Journal of Infectious Diseases, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Postpandemic surveillance data on coronavirus disease 2019 (COVID-19) infections may help inform future public health policies regarding severe acute respiratory syndrome 2 (SARS-CoV-2) testing, vaccinations, or other COVID-19 measures. We estimate the total SARS-CoV-2 in Austria after end of pandemic from wastewater and utilize these estimates to calculate average national levels infection protection death protection. estimated (5 May 2023, per World Health Organization) up 2024 using a previously published model. These were used an agent-based model (ABM) protection, based waning immunity vaccination previous literature. approximately 3.2 million between 6 2023 23 2024, with 17.8 following 12 2020. The ABM that was 82% higher than before pandemic. This represents relative decrease 8% since 2023. It also shows 95% people infected at least once by 2024. National remained relatively low onset Omicron. findings should be considered for decisions testing practices vaccine booster administrations.

Язык: Английский

---

Biosensor Technologies for Water Quality: Detection of Emerging Contaminants and Pathogens

Biosensors, Год журнала: 2025, Номер 15(3), С. 189 - 189

Опубликована: Март 15, 2025

This review explores the development, technological foundations, and applications of biosensor technologies across various fields, such as medicine for disease diagnosis monitoring, food industry. However, primary focus is on their use in detecting contaminants pathogens, well environmental monitoring water quality assessment. The classifies different types biosensors based bioreceptor transducer, highlighting how they are specifically designed detection emerging (ECs) pathogens water. Key innovations this technology critically examined, including advanced techniques systematic evolution ligands by exponential enrichment (SELEX), molecularly imprinted polymers (MIPs), self-assembled monolayers (SAMs), which enable fabrication sensors with improved sensitivity selectivity. Additionally, integration microfluidic systems into analyzed, demonstrating significant enhancements performance speed. Through these advancements, work emphasizes fundamental role key tools safeguarding public health preserving integrity.

Язык: Английский

---

The Breadth of Bacteriophages Contributing to the Development of the Phage-Based Vaccines for COVID-19: An Ideal Platform to Design the Multiplex Vaccine

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(2), С. 1536 - 1536

Опубликована: Янв. 12, 2023

Phages are highly ubiquitous biological agents, which means they ideal tools for molecular biology and recombinant DNA technology. The development of a phage display technology was turning point in the design phage-based vaccines. now recognized as universal adjuvant-free nanovaccine platforms. well-suited vaccine owing to their high stability harsh conditions simple inexpensive large-scale production. aim this review is summarize overall breadth antiviral therapeutic perspective phages contributing vaccines COVID-19. We show that induce strong specific humoral response by targeted particles carrying epitopes SARS-CoV-2. Further, engineering T4 bacteriophage CRISPR (clustered regularly interspaced short palindromic repeats) presents valuable platform with potential capabilities genetic plasticity, intrinsic immunogenicity, stability.

Язык: Английский

---

Real-Time On-Site Monitoring of Viruses in Wastewater Using Nanotrap® Particles and RICCA Technologies

Biosensors, Год журнала: 2024, Номер 14(3), С. 115 - 115

Опубликована: Фев. 21, 2024

Wastewater-based epidemiology (WBE) is an effective and efficient tool for the early detection of infectious disease outbreaks in a community. However, currently available methods are laborious, costly, time-consuming due to low concentration viruses presence matrix chemicals wastewater that may interfere with molecular analyses. In present study, we designed highly sensitive “Quick Poop (wastewater fecal waste) Sensor” (termed, QPsor) using joint approach Nanotrap microbiome particles RICCA (RNA Isothermal Co-Assisted Coupled Amplification). Using QPsor, WBE study showed strong correlation standard PEG concentrations qPCR technique. closed format paper-based lateral flow assay, were able demonstrate potential our assay as real-time, point-of-care test by detecting heat-inactivated SARS-CoV-2 virus at 100 copies/mL within one hour. As proof-of-concept demonstration, analyzed viral RNA PMMoV raw samples from treatment plants on-site 60 min. The results show QPsor method can be outbreak combining AI-enabled case model real-time extraction amplification, especially absence intensive clinical laboratory facilities. lab-free, lab-quality capabilities prevalence transmission community contribute management pandemic situations.

Язык: Английский

---

Tracking epidemic viruses in wastewaters

Microbial Biotechnology, Год журнала: 2024, Номер 17(10)

Опубликована: Окт. 1, 2024

Classical epidemiology relies on incidence, mortality rates, and clinical data from individual testing, which can be challenging for many countries. Therefore, innovative, flexible, cost-effective, scalable surveillance techniques are needed. Wastewater-based (WBE) has emerged as a highly powerful tool in this regard. WBE analyses substances excreted human fluids faeces that enter the sewer system. This approach provides insights into community health status lifestyle habits. serves an early warning system viral surveillance, detecting emergence of new pathogens, changes incidence identifying future trends, studying outbreaks, informing performance action plans. While long been used to study different viruses such poliovirus norovirus, its implementation surged due pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2. led establishment wastewater programmes at international, national, levels, remain operational. Furthermore, is increasingly applied other including antibiotic resistance bacteria, parasites, fungi, emerging viruses, with methodologies being developed. Consequently, primary focus now creating international frameworks enhance states' preparedness against risks. However, there remains considerable work done, particularly integrating principles One Health epidemiological acknowledge interconnectedness humans, animals, environment pathogen transmission. Thus, broader analysing three pillars must developed, transitioning environmental establishing routine practice public health.

Язык: Английский

---

Bioinformatics in Monitoring and Enhancing Wastewater Treatment Processes

Advances in environmental engineering and green technologies book series, Год журнала: 2025, Номер unknown, С. 457 - 484

Опубликована: Янв. 16, 2025

Bioinformatics is essential in monitoring and improving wastewater treatment processes. Various spectroscopic methods combined with chemometric tools are effective for controlling bioprocesses systems. Integrating metagenomic sequencing viral epidemiology enhances the of pathogenic viruses wastewater, offering predictive intelligence virus-related diseases. In biological treatment, innovative approaches like microbial sensors enhanced process propose to enhance control efficiency plants.

Язык: Английский

---