Updated mechanisms of MASLD pathogenesis

Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)

Опубликована: Апрель 22, 2024

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) has garnered considerable attention globally. Changing lifestyles, over-nutrition, and physical inactivity have promoted its development. MASLD is typically accompanied by obesity strongly linked to metabolic syndromes. Given that prevalence on the rise, there an urgent need elucidate pathogenesis. Hepatic lipid accumulation generally triggers lipotoxicity induces or progress steatohepatitis (MASH) mediating endoplasmic reticulum stress, oxidative organelle dysfunction, ferroptosis. Recently, significant been directed towards exploring role of gut microbial dysbiosis in development MASLD, offering a novel therapeutic target for MASLD. Considering are no recognized pharmacological therapies due diversity mechanisms involved difficulty associated with undertaking clinical trials, potential targets remain elusive. Thus, this article aimed summarize evaluate prominent roles lipotoxicity, ferroptosis, microbes underlying their effects. Furthermore, existing advances challenges treatment were outlined.

Язык: Английский

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Shenling Baizhu San ameliorates non-alcoholic fatty liver disease in mice by modulating gut microbiota and metabolites

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Апрель 24, 2024

The prevalence of non-alcoholic fatty liver disease (NAFLD) and its related mortality is increasing at an unprecedented rate. Traditional Chinese medicine (TCM) has been shown to offer potential for early prevention treatment NAFLD. new mechanism "Shenling Baizhu San" (SLBZS) examined in this study the NAFLD preclinical level.

Язык: Английский

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Impact of Linggui Zhugan decoction on microwave ablation outcomes and recurrence in liver cancer

World Journal of Gastrointestinal Oncology, Год журнала: 2025, Номер 17(2)

Опубликована: Янв. 18, 2025

Liver cancer is one of the most common malignant tumors digestive system, and early detection effective treatment are crucial for improving prognosis. Microwave ablation (MWA) has shown promising results as a local therapeutic method liver cancer; however, further improvement its efficacy remains key focus current research. To evaluate clinical Linggui Zhugan decoction combined with MWA primary cancer. Data were collected from 164 patients who underwent at our hospital between March 2019 April 2021. Among them, 79 (control group) received routine treatments 85 (research in addition to treatment. The efficacy, incidence adverse reactions, levels serum alpha-fetoprotein (AFP), des-γ-carboxy prothrombin (DCP), AFP-L3, total bilirubin (TBil), alanine aminotransferase (ALT), CD4 cell count, CD8 CD4/CD8 ratio compared two groups, before after three-year recurrence rates groups compared, independent prognostic factors identified. study revealed that objective response rate (ORR) research group was significantly higher than control (P = 0.005). After treatment, count increased, whereas TBil, ALT, AFP, DCP, AFP-L3 Levels lower < 0.001). Cox regression analysis regimen 0.003), presence cirrhosis 0.019), tumor diameter 0.037), Child-Pugh score pretreatment AFP level 0.006), Level 0.002) disease-free survival. combination improved long-term prognosis

Язык: Английский

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Xiaohua Funing decoction ameliorates non-alcoholic fatty liver disease by modulating the gut microbiota and bile acids

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Фев. 10, 2025

Introduction The gut microbiota and bile acids (BAs) have emerged as factors involved in the development of non-alcoholic fatty liver disease (NAFLD). Xiaohua Funing decoction (XFD) is a traditional Chinese medicine formula used for treatment NAFLD. Previous studies indicated that XFD protects function, but underlying mechanism remains unclear. Methods In this study, Wistar rat model NAFLD (Mod) was established via high-fat diet. effects obeticholic acid (OCA) on Mod rats were subsequently evaluated. control (Con) group fed standard There eight each group, lasted 12 weeks. Furthermore, metagenomic sequencing BA metabolomic analyses performed. Results Compared to Con presented significant differences body weights; serum total cholesterol (TC) triglyceride (TG) levels; TG, TC, salt hydrolase levels ( p &lt; 0.05 or 0.01). Importantly, OCA administration normalized these indicators Pathology white fat steatosis observed significantly alleviated groups abundances Bacteroidales_bacterium , Prevotella_ sp., bacterium_0.1xD8-71 unclassified_g_Turicibacter different from those 0.01), whereas abundance greater group. A 17, 24, 24 differentially abundant BAs detected feces, liver, samples groups, respectively serum, 16, 23, 14 BAs, respectively, including glycochenodeoxycholic acid, deoxycholic murideoxycholic lithocholic 23-nordeoxycholic 3β-ursodeoxycholic acid. addition, identified potential biomarker Discussion summary, our experiments revealed regulates providing beneficial lipid accumulation

Язык: Английский

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Effects of probiotics in patients with morbid obesity undergoing bariatric surgery: a systematic review and meta-analysis

International Journal of Obesity, Год журнала: 2023, Номер 47(11), С. 1029 - 1042

Опубликована: Сен. 6, 2023

Abstract Background Probiotics are commonly used after bariatric surgery. However, uncertainty remains regarding their effects. The purpose of this systematic review was to assess the effect probiotics in patients with morbid obesity undergoing Methods PubMed, Cochrane Library, Embase, Science Direct, and Web were searched from inception April 4, 2023. No language restrictions applied. Relevant randomized controlled trials clinical included. We aggregated data extracted assessed heterogeneity. When severe heterogeneity detected, a random model used. All stages done by independent authors. Results screened 2024 references included 11 trials. Compared protocol groups, showed significant effects on regulating aspartate amino transferase level (MD = −4.32 U/L; 95% CI [−7.10, −1.53], p 0.002), triglycerides −20.16 mg/dL; [−34.51, −5.82], 0.006), weight −1.99 kg; [−3.97, −0.01], 0.05), vitamin B 12 2.24 pg/dL; [−0.02, 4.51], dietary energy −151.03 kcal; [−215.68, −86.37], < 0.00001), protein −4.48 g/day, [−8.76, −0.20], 0.04), carbohydrate −34.25 [−44.87, −23.62], fiber −2.17 [−3.21, −1.14], 0.0001). There no side related probiotics. Conclusions Our meta-analysis suggested that may delay progression liver function injury, improve lipid metabolism, reduce weight, food intake, although other indicators insignificant. be helpful for registered PROSPERO (International prospective register reviews): CRD42023407970. primary source funding.

Язык: Английский

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An herbal formulation “Shugan Xiaozhi decoction” ameliorates methionine/choline deficiency-induced nonalcoholic steatohepatitis through regulating inflammation and apoptosis-related pathways

Journal of Ethnopharmacology, Год журнала: 2024, Номер 329, С. 118127 - 118127

Опубликована: Апрель 5, 2024

Shugan Xiaozhi (SGXZ) decoction is a traditional Chinese medicine used for treating nonalcoholic steatohepatitis (NASH). It has been clinically over 20 years and proved to be effective; however, the molecular mechanism underlying effects of SGXZ remains unclear.

Язык: Английский

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Ling-Gui-Zhu-Gan decoction ameliorates nonalcoholic fatty liver disease via modulating the gut microbiota

Microbiology Spectrum, Год журнала: 2024, Номер 12(6)

Опубликована: Апрель 22, 2024

Numerous studies have supported that nonalcoholic fatty liver disease (NAFLD) is highly associated with gut microbiota dysbiosis. Ling-Gui-Zhu-Gan decoction (LG) has been clinically used to treat NAFLD, but the underlying mechanism remains unknown. This study investigated therapeutic effect and mechanisms of LG in mice NAFLD induced by a high-fat diet (HD). An HD-induced model was established evaluate efficacy followed biochemical histopathological analysis. Metagenomics, metabolomics, transcriptomics were explore structure metabolism microbiota. significantly improved hepatic function decreased lipid droplet accumulation mice. reversed damaged HD intestinal barrier function. Meanwhile, group showed lower total blood bile acids (BAs) concentration, shifted BAs composition, higher fecal short-chain (SCFAs) concentration. Furthermore, could regulate expression genes primary biosynthesis pathway peroxisome proliferator-activated receptor (PPAR) signaling pathway. Our suggested ameliorate altering microbiota, while SCFAs are considered possible mediating substances.

Язык: Английский

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Protective effects of yeast extract against alcohol-induced liver injury in rats

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Июль 20, 2023

Oxidative stress, inflammatory response, and gut-liver axis dysbiosis have been suggested as the primarily involved in pathogenesis of alcoholic liver injury. Previous research established that yeast extract (YE) has antioxidant, immune-boosting or microbiota-regulating properties. However, there is currently lack information regarding efficacy YE on This study seeks to obtain data will help address this gap using a Wistar male rat experimental model. Histologic biochemical analysis results showed groups treated with both low-dose (YEL) high-dose (YEH) had lower degrees alcohol-induced The abundance Peptococcus Ruminococcus reduced group, while , Romboutsia, Parasutterella Faecalibaculum group. Furthermore, Spearman gut microbes were significantly associated several liver-related indicators. For differential metabolites enriched pathways YEL lysophosphatidylcholine (16:0/0:0) increased, then levels histamine, adenosine 5′ -adenine nucleotide remarkedly elevated YEH These findings suggest high low doses can different protective effects injury disease (ALD) rats, addition improving microbiota disorder. Besides, found be more effective than metabolic regulation, well dealing oxidative stress responses.

Язык: Английский

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Modulation of gut microbiota by crude gac aril polysaccharides ameliorates diet-induced obesity and metabolic disorders

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 273, С. 133164 - 133164

Опубликована: Июнь 14, 2024

Obesity is a global health challenge that causes metabolic dysregulation and increases the risk of various chronic diseases. The gut microbiome crucial in modulating host energy metabolism, immunity, inflammation influenced by dietary factors. Gac fruit (Momordica cochinchinensis), widely consumed Southeast Asia, has been proven to have biological activities. However, composition effect crude gac aril polysaccharides (GAP) on obesity microbiota disturbed high-fat diet (HFD) remain be elucidated. Compositional analysis showed GAP contains high oligosaccharides, with an average 7–8 saccharide units. To mimic clinical obesity, mice were first made obese feeding HFD for eight weeks. intervention was performed from week 9 20 HFD-fed mice. Our results inhibited body weight gain, eWAT adipocyte hypertrophy, adipokine derangement, hyperlipidemia HFD-induced improved insulin sensitivity, impaired glucose tolerance, hepatic steatosis. modulated reversed dysbiosis at least genera. Taken together, improves modulates relieve factors, demonstrating potential treating obesity-associated disorders.

Язык: Английский

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Serum Metabolomics Uncovers the Mechanisms of Inulin in Preventing Non-Alcoholic Fatty Liver Disease

Pharmaceuticals, Год журнала: 2024, Номер 17(7), С. 895 - 895

Опубликована: Июль 5, 2024

Inulin may be a promising therapeutic molecule for treating non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanisms of its activity remain unclear. To address this issue, high-fat-diet-induced NAFLD mouse model was developed and treated with inulin. The phenotype evaluated via histopathological analysis biochemical parameters, including serum levels alanine aminotransferase, aspartate triglycerides, etc. A metabolomics study conducted using ultra-performance liquid chromatography coupled tandem mass spectrometry. results revealed that inulin mitigated symptoms such as changes cholesterol levels. Through study, 347 differential metabolites were identified between control groups, 139 groups. Additionally, 48 (such phosphatidylserine, dihomo-γ-linolenic acid, L-carnitine, 13-HODE) candidate targets subjected to pathway enrichment analysis. these enriched in several metabolic pathways acid biosynthesis cardiolipin biosynthesis. Taken together, our suggest might attenuate partially by modulating their correlated pathways, constituting information help us find novel therapies NAFLD.

Язык: Английский

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