Comparative Analysis of Gut Microbiota in Humans Living with and Without Companion Animals DOI Creative Commons
Kyung-Hyo Do, Jiwon Park, Nahee Kim

и другие.

Life, Год журнала: 2024, Номер 14(12), С. 1621 - 1621

Опубликована: Дек. 6, 2024

Cohabitation with companion animals (CAs) has been suggested as a significant modifier of gut microbial diversity. This study investigated the influence cohabitation CAs on human microbiota composition. Using 16S rRNA gene sequencing, we analyzed 20 families (40 adults, children) and without children). Alpha beta diversity analyses were performed, differentially abundant genera identified. There differences in across groups (p-value = 0.001). The Bacillota/Bacteroidota ratio was considerably lower group (0.67) than without-CAs (1.02). Prevotellaceae_UCG-003 (log2 fold change: 7.3; adjusted p-value ≤ 0.001), Ruminococcaceae 6.3; Oscillospira 5.1; 0.012) elevated cohabiting CAs, whereas Megamonas (with CAs: 3.81%; 13.52%) Veillonella 3.77%; 6.50%) more prevalent CAs. may positively by promoting presence beneficial bacteria reducing ratio. highlights potential for to promote health.

Язык: Английский

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions DOI Creative Commons
Yong Qiu, Chunheng Mo, Lu Chen

и другие.

MedComm, Год журнала: 2024, Номер 5(4)

Опубликована: Март 15, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently caused a global pandemic, resulting in more than 702 million people being infected and over 6.9 deaths. Patients with disease (COVID-19) may suffer from diarrhea, sleep disorders, depression, even cognitive impairment, which is associated long COVID during recovery. However, there remains no consensus on effective treatment methods. Studies have found that patients COVID-19 alterations microbiota their metabolites, particularly the gut, be involved regulation of immune responses. Consumption probiotics alleviate discomfort by inflammation oxidative stress. pathophysiological process underlying alleviation COVID-19-related symptoms complications targeting unclear. In current study, we summarize latest research evidence together SARS-CoV-2 vaccine use, focus relationship between use. This work provides probiotic-based interventions improve regulating gut systemic immunity. Probiotics also used as adjuvants to efficacy.

Язык: Английский

Процитировано

8
The Effect of Broccoli Glucoraphanin Supplementation on Ameliorating High‐Fat‐Diet‐Induced Obesity through the Gut Microbiome and Metabolome Interface DOI Creative Commons
Taiwo Bankole, Tianzhou Ma, Itika Arora

и другие.

Molecular Nutrition & Food Research, Год журнала: 2024, Номер 68(9)

Опубликована: Апрель 27, 2024

Scope Obesity and its metabolic comorbidities pose a major global challenge for public health. Glucoraphanin (GRN) is natural bioactive compound enriched in broccoli that known to have potential health benefits against various human chronic diseases. Methods results This study investigats the effects of GRN supplementation on body weight, parameters, gut microbiome metabolome associated with obesity. The conducted an obese‐related C57BL/6J mouse model through treatment normal control diet, high‐fat diet (HFD)and GRN‐supplemented HFD (HFD‐GRN) determine protection GRN. shows alleviates obesity‐related traits leading improved glucose metabolism HFD‐fed animals. Mechanically, noticed significantly shifts microbial diversity composition eubiosis status. supplement also alters plasma metabolite profiles. Further integrated analysis reveal complex interaction between microbes host may contribute GRN‐induced beneficial HFD. Conclusion These indicate reversing HFD‐induced adverse parameters be attributed impacts reprogramming community metabolites. Identification mechanistic functions further warrants it as dietary candidate obesity prevention.

Язык: Английский

Процитировано

4
Oral Immunisation With Non‐GMO Surface Displayed SARS‐CoV‐2 Spike Epitopes on Bacteria‐Like Particles Provokes Robust Humoral and Cellular Immune Responses, and Modulated the Gut Microbiome in Mice DOI Creative Commons
Robie Vasquez, Ji Hoon Song, Remilyn M. Mendoza

и другие.

Microbial Biotechnology, Год журнала: 2025, Номер 18(1)

Опубликована: Янв. 1, 2025

ABSTRACT The coronavirus disease 2019 (COVID‐19) is a fatal caused by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). To date, several vaccines have been developed to combat the spread of this virus. Mucosal using food‐grade bacteria, such as Lactobacillus spp., are promising strategies for developing safe and effective against SARS‐CoV‐2. In study, we designed non‐GMO surface‐displayed SARS‐CoV‐2 spike S1 epitope on Limosilactobacillus fermentum ‐derived bacteria‐like particles (BLPs). After that, evaluated its efficacy induce immune responses in immunocompetent mice. Moreover, examined influence oral immunisation gut microbiome microbiota metabolites. Twenty‐eight 6‐week‐old male C57BL/6 mice were orally immunised with following: PBS (control), Lm. BLPs only, displaying S1‐2, or S1‐3 epitopes. Our results showed that mucosal epitopes provoked high‐level secretory IgA systemic IgG production. exhibited Th1‐like response, characterised an elevated IgG2a‐to‐IgG1 ratio high antiviral IFN‐γ addition, observed modulation increased butyrate production Overall, use anchor CshA display S1epitopes novel strategy cost‐effective, vaccine alternative

Язык: Английский

Процитировано

0
Hidden Partner of Immunity: Microbiome as an Innovative Companion in Immunotherapy DOI Open Access

P. Kim,

Sook-Haeng Joe, Heeyoung Kim

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 856 - 856

Опубликована: Янв. 20, 2025

Recent studies have highlighted that the microbiome is essential factor can modulate clinical activity of immunotherapy. However, role varies significantly across different immunotherapies, suggesting it critical to understand precise function in each type While many previous primarily focus on summarizing immune checkpoint inhibitors, we seek explore a novel aspect other immunotherapies such as mesenchymal stem cell therapy, chimeric antigen receptor T and antibodies-based therapy (e.g., adalimumab, infliximab, bevacizumab, denosumab, etc.) which are rarely summarized reviews. Moreover, highlight innovative strategies for utilizing microbial metabolites enhance response Collectively, believe our manuscript will provide insights approaches researchers, could drive development next generation personalized therapeutic interventions using microbiomes.

Язык: Английский

Процитировано

0
Unraveling intestinal microbiota’s dominance in polycystic ovary syndrome pathogenesis over vaginal microbiota DOI Creative Commons
Yu Xia,

XiaoQin Li,

Hui Yang

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Март 28, 2024

Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disease in women, intricately linked to hormonal imbalances. The microbiota composition plays pivotal role influencing levels within the body. In this study, we utilized murine model investigate how intestinal and vaginal interact with hormones development of PCOS. Methods Twenty female mice were randomly assigned normal group (N) (P), where latter received daily subcutaneous injections 0.1 mL DHEA (6 mg/100 g). Throughout experiment, evaluated PCOS mouse by estrus cycle, serum total testosterone (T), prolactin (PRL) luteinizing hormone (LH) levels, ovarian pathological morphology. microbial both content studied 16S rRNA gene high-throughput sequencing. Results Compared N group, P showed significant increases body weight, T, PRL, decrease LH. Ovaries exhibited polycystic changes, estrous cycle was disrupted. result shows that Chao1, ACE, Shannon Simpson indexes decreased, Desulfobacterota Acidobacteriota increased, Muribaculaceae , Limosilactobacillus Lactobacillus decreased group. T significantly positively correlated Enterorhabdus LH Lactobacillus. analysis revealed no changes Shannon, indices. However, there increased Firmicutes, Bacteroidota, Actinobacteriota, Streptococcus . Particularly, Rodentibacter displayed robust negative correlation other components microbiota. Conclusion Therefore, response more than likely involved through its participation regulation.

Язык: Английский

Процитировано

2
Combination of lipopolysaccharide and polygalacturonic acid exerts antitumor activity and augments anti-PD-L1 immunotherapy DOI
Jie Song, Jiaxin Li, Anping Zhang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 281, С. 136390 - 136390

Опубликована: Окт. 9, 2024

Язык: Английский

Процитировано

1
Characterization of Gut Microbiota in Rats and Rhesus Monkeys After Methamphetamine Self-administration DOI
Li He,

Jiahui Zhou,

Huan Li

и другие.

Molecular Neurobiology, Год журнала: 2024, Номер unknown

Опубликована: Июнь 26, 2024

Язык: Английский

Процитировано

0
Comparative Analysis of Gut Microbiota in Humans Living with and Without Companion Animals DOI Creative Commons
Kyung-Hyo Do, Jiwon Park, Nahee Kim

и другие.

Life, Год журнала: 2024, Номер 14(12), С. 1621 - 1621

Опубликована: Дек. 6, 2024

Cohabitation with companion animals (CAs) has been suggested as a significant modifier of gut microbial diversity. This study investigated the influence cohabitation CAs on human microbiota composition. Using 16S rRNA gene sequencing, we analyzed 20 families (40 adults, children) and without children). Alpha beta diversity analyses were performed, differentially abundant genera identified. There differences in across groups (p-value = 0.001). The Bacillota/Bacteroidota ratio was considerably lower group (0.67) than without-CAs (1.02). Prevotellaceae_UCG-003 (log2 fold change: 7.3; adjusted p-value ≤ 0.001), Ruminococcaceae 6.3; Oscillospira 5.1; 0.012) elevated cohabiting CAs, whereas Megamonas (with CAs: 3.81%; 13.52%) Veillonella 3.77%; 6.50%) more prevalent CAs. may positively by promoting presence beneficial bacteria reducing ratio. highlights potential for to promote health.

Язык: Английский

Процитировано

0