Epitope-Based Vaccines: The Next Generation of Promising Vaccines Against Bacterial Infection
Vaccines,
Год журнала:
2025,
Номер
13(3), С. 248 - 248
Опубликована: Фев. 27, 2025
The
increasing
resistance
of
bacteria
to
antibiotics
has
underscored
the
need
for
new
drugs
or
vaccines
prevent
bacterial
infections.
Reducing
multidrug
is
a
key
objective
WHO’s
One
Health
initiative.
Epitopes,
parts
antigen
molecules
that
determine
their
specificity,
directly
stimulate
body
produce
specific
humoral
and/or
cellular
immune
responses.
Epitope-based
vaccines,
which
combine
dominant
epitopes
in
rational
manner,
induce
more
efficient
and
response
than
original
antigen.
While
these
face
significant
challenges,
such
as
epitope
escape
low
immunogenicity,
they
offer
advantages
including
minimal
adverse
reactions,
improved
efficacy,
optimized
protection.
As
result,
epitope-based
are
considered
promising
next-generation
approach
combating
This
review
summarizes
latest
advancements,
future
prospects
targeting
bacteria,
with
focus
on
development
workflow
application
antibiotic-resistant
pathogens
high
mortality
rates,
Staphylococcus
aureus,
Streptococcus
pneumoniae,
pyogenes,
Klebsiella
Acinetobacter
baumannii,
Pseudomonas
aeruginosa.
goal
this
provide
insights
into
vaccination
strategies
combat
infections
associated
antibiotic
rates.
Язык: Английский
Recent Advances in Immunotherapeutic and Vaccine-Based Approaches for the Treatment of Drug-Resistant Bacterial Infections
ACS Infectious Diseases,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 2, 2025
Antimicrobial
resistance
poses
a
grave
threat
to
global
public
health.
Although
new
antibiotics
are
urgently
needed,
most
share
mechanisms
with
existing
drugs,
thereby
necessitating
the
development
of
alternative
antibacterial
therapeutics.
Various
immunotherapeutic
agents,
including
monoclonal
antibodies,
therapeutic
vaccines,
cellular
therapies,
and
immunomodulators,
have
been
developed
explored
treat
drug-resistant
bacterial
infections.
This
review
comprehensively
summarizes
recent
advancements
in
immunotherapies
vaccine-based
approaches
as
strategies
combat
Our
findings
indicate
that
immunotherapy
offers
several
advantages
over
traditional
antibiotics,
such
enhanced
specificity,
long-term
effects,
overcoming
mechanisms,
broad
applicability,
potential
for
combination
personalized
medicine,
reduced
toxicity.
Also,
formulation
delivery
strategies,
nanoparticles,
liposomes,
vehicles,
diverse
administration
routes,
employed
improve
efficacy
targeting
these
agents.
In-depth
evaluations
promising
preclinical
clinical
studies
demonstrate
their
effectiveness
against
pathogens
Pseudomonas
aeruginosa,
Escherichia
coli,
Mycobacterium
tuberculosis,
Streptococcus
pneumoniae,
methicillin-resistant
Staphylococcus
aureus,
Acinetobacter
baumannii,
Helicobacter
pylori.
These
suggest
is
address
growing
challenge
infections,
potentially
revolutionizing
infection
management
strategies.
Язык: Английский
Design, development, and assessment of a novel multi-peptide vaccine targeting PspC, PsaA, and PhtD proteins of Streptococcus pneumoniae
Zohreh Bahadori,
Mona Shafaghi,
jahangir sabzevari
и другие.
International Journal of Biological Macromolecules,
Год журнала:
2023,
Номер
258, С. 128924 - 128924
Опубликована: Дек. 22, 2023
Язык: Английский
Pneumococcal Surface Proteins as Targets for Next-Generation Vaccines: Addressing the Challenges of Serotype Variation
Sangeetha Gopalakrishnan,
Premkumar Jayapal,
James John
и другие.
Diagnostic Microbiology and Infectious Disease,
Год журнала:
2025,
Номер
113(1), С. 116870 - 116870
Опубликована: Апрель 28, 2025
Язык: Английский
Peptide vaccines: an innovative therapeutic approach against antibiotic-resistant bacterial infections
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Май 21, 2025
Bacterial
infections
continue
to
pose
a
serious
threat
global
health,
especially
with
the
growing
challenge
of
multidrug-resistant
pathogens.
While
traditional
vaccines
have
been
pivotal
in
reducing
disease
burden,
they
come
limitations
such
as
variable
efficacy,
safety
concerns,
and
limited
ability
address
diversity
bacterial
strains.
This
review
highlights
promise
peptide-based
an
innovative
approach
overcoming
these
hurdles.
By
targeting
specific
regions
proteins,
peptide
can
elicit
precise
immune
responses
improved
broader
applicability.
Advances
technology,
including
bioinformatics
delivery
systems,
enhanced
their
design,
making
them
more
stable,
effective,
easier
produce.
These
work
by
activating
both
antibody
T-cell
through
well-defined
mechanisms.
Different
types,
linear
peptides,
cyclic
synthetic
long
offer
diverse
strategies
tailor
protection.
The
role
adjuvants
advanced
methods,
like
nanoparticles
liposomes,
further
improve
potential.
Exciting
progress
has
made
against
ESKAPE
pathogens
-
Enterococcus
faecium,
Staphylococcus
aureus,
Klebsiella
pneumoniae,
Acinetobacter
baumannii,
Pseudomonas
aeruginosa,
Enterobacter
spp.
Peptide
forward-thinking,
adaptable
solution
reduce
mitigate
rise
antibiotic
resistance,
paving
way
for
safer
effective
prevention
strategies.
underscores
critical
combating
infections,
advocating
ongoing
research
unlock
full
Язык: Английский