NAFLD/MASLD and the Gut–Liver Axis: From Pathogenesis to Treatment Options

Metabolites, Год журнала: 2024, Номер 14(7), С. 366 - 366

Опубликована: Июнь 28, 2024

Nonalcoholic fatty liver disease (NAFLD) poses an emerging threat topublic health. steatohepatitis (NASH) is reported to be the most rapidly rising cause of hepatocellular carcinoma in western world. Recently, a new term has been proposed: metabolic dysfunction-associated steatotic (MASLD). The introduction this terminology sparked debate about interchangeability these terms. pathogenesis NAFLD/MASLD thought multifactorial, involving both genetic and environmental factors. Among factors, alterations gut microbiota dysbiosis have recently garnered significant attention. In context, review will further discuss gut-liver axis, which refers bidirectional interaction between human liver. Additionally, therapeutic potential probiotics, particularly next-generation probiotics genetically engineered bacteria, explored. Moreover, role prebiotics, synbiotics, postbiotics, phages as well fecal transplantation analyzed. Particularly for lean patients with NAFLD/MASLD, who limited treatment options, approaches that modify diversity composition may hold promise. However, due ongoing safety concerns modulate microbiota, large-scale studies are necessary better assess their efficacy treating NAFLD/MASLD.

Язык: Английский

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Exploration of capsaicin-encapsulated lignin nanoparticles for alleviating non-alcoholic fatty liver disease: In-vitro study

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 303, С. 140616 - 140616

Опубликована: Фев. 3, 2025

Язык: Английский

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Health benefits of medicinal plant natural products via microbiota-mediated different gut axes

Pharmacological Research, Год журнала: 2025, Номер unknown, С. 107730 - 107730

Опубликована: Апрель 1, 2025

This review examines the multifaceted roles of medicinal plant natural products in influencing gut microbiota and their subsequent impact on various organ systems through established axes, including gut-brain, gut-liver, gut-heart, gut-lung, gut-kidney axes. Medicinal have exhibited diverse pharmacological activities, modulation composition, enhancement metabolic processes, alleviation inflammation oxidative stress. Evidence suggests that these components can ameliorate conditions such as neurological disorders, syndrome, chronic kidney disease by restoring microbial balance improving barrier integrity. Furthermore, highlights potential to foster beneficial communities improve health, which may lead reduced severity inflammation. By comprehensively analyzing current literature, this provides a foundation for future research aim at exploring therapeutic applications prevention treatment. The findings underscore need further studies elucidate underlying mechanisms action validate clinical efficacy managing modulation.

Язык: Английский

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Bacteroides uniformis-generated hexadecanedioic acid ameliorates metabolic-associated fatty liver disease

Gut Microbes, Год журнала: 2025, Номер 17(1)

Опубликована: Май 25, 2025

Gut microbiota exerts a pivotal influence on the development of Metabolic Associated Fatty Liver Disease (MAFLD), although specific contributions individual bacterial strains and their metabolites remain poorly defined. We conducted stool shotgun metagenomic sequencing plasma untargeted metabolomics in large prospective cohort comprising 120 MAFLD patients matched healthy controls. The mechanisms microbial-derived involved were further investigated through multi-omics analyses vitro vivo. Distinct differences identified both microbial community structure metabolomic profiles between Bacteroides uniformis (B. uniformis) was most significantly depleted species negatively correlated with hepatic steatosis BMI. characterized by marked disruptions fatty acid amino metabolism. Combined analysis data achieved high diagnostic accuracy for severity (AUC = 0.93). Transplantation fecal from subjects into ABX mice led to onset MAFLD-like symptoms, whereas B. administration alleviate disease progression inhibiting intestinal fat absorption, FFA eWAT influx liver via gut-liver axis, IRE1α-XBP1s-mediated flipogenesis ferroptosis, as confirmed transcriptomic proteomic analyses. Hexadecanedioic (HDA), potentially key metabolite produced uniformis, ameliorated symptoms. Mechanistically, uniformis-derived HDA also inhibited absorption transported, entered portal vein suppress ferroptosis. its potential putative may contribute modulation, regulation IRE1α-XBP1s axis. This study provides new insights axis offers promising therapeutic targets based microbes metabolites.

Язык: Английский

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Β-Ecdysterone and Sarsasapogenin, First Isolated from Polygonatum Kingianum, Reveal its Therapeutic Potential in Mafld Via 16s Rrna Sequencing and Metabolomics

Опубликована: Янв. 1, 2025

Язык: Английский

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Hepatic Steatosis is Generated by the Gut Microbiota-Mitochondria Axis via 2-oleolyl Glycerol and Reverted by Functional Foods

Опубликована: Июль 10, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a serious health problem, and recent evidence indicates that gut microbiota plays key role in its development. It known 2-oleoyl glycerol (2-OG) produced by the associated with hepatic fibrosis, but it not whether this metabolite involved development of steatosis. The aim study was to evaluate how high-fat sucrose diet (HFS) increases 2-OG production through dysbiosis identify modifies lipogenesis mitochondrial activity for steatosis as well combination functional foods can reverse process. Wistar rats were fed HFS 7 mo. At end study, body composition, biochemical parameters, microbiota, protein abundance lipogenic antioxidant enzymes, measurement 2-OG, function assessed we studied effect foods. In humans MASLD, analyzed serum 2-OG. Consumption caused oxidative stress, dysbiosis, decreasing α-diversity increased Blautia producta abundance, which This de novo ChREBP SREBP-1. significantly dysfunction. Addition modified reducing B. levels, leading decrease weight gain, fat mass, glucose, insulin, cholesterol, triglycerides, fatty formation, function. order use biomarker, measured healthy subjects or MASLD observed II III had higher than subjects, suggesting circulating could be predictor marker

Язык: Английский

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Hepatic Steatosis Can Be Partly Generated by the Gut Microbiota–Mitochondria Axis via 2-Oleoyl Glycerol and Reversed by a Combination of Soy Protein, Chia Oil, Curcumin and Nopal

Nutrients, Год журнала: 2024, Номер 16(16), С. 2594 - 2594

Опубликована: Авг. 6, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a serious health problem, and recent evidence indicates that gut microbiota plays key role in its development. It known 2-oleoyl glycerol (2-OG) produced by the associated with hepatic fibrosis, but it not whether this metabolite involved development of steatosis. The aim study was to evaluate how high-fat–sucrose diet (HFS) increases 2-OG production through dysbiosis identify modifies lipogenesis mitochondrial activity for steatosis as well combination functional foods can reverse process. Wistar rats were fed HFS 7 months. At end study, body composition, biochemical parameters, microbiota, protein abundance, lipogenic antioxidant enzymes, measurement, function evaluated. Also, effect consumption food an assessed. In humans MASLD, we analyzed serum 2-OG. Consumption caused oxidative stress, steatosis, dysbiosis, decreasing α-diversity increased Blautia producta which This de novo ChREBP SREBP-1. significantly dysfunction. addition modified reducing levels, leading decrease weight gain, fat mass, glucose, insulin, cholesterol, triglycerides, fatty formation, function. To use biomarker, measured healthy subjects or observed II III had higher than subjects, suggesting abundance circulating could be predictor marker

Язык: Английский

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Isolation and structural characterization of flavonoids from E Se tea and their synergistic inhibitory effects on lipid accumulation via regulating AMPK/ACC pathway

Food Bioscience, Год журнала: 2024, Номер 60, С. 104517 - 104517

Опубликована: Июнь 5, 2024

Язык: Английский

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