Interconnections between BDH1-plasma protein-type 2 diabetes Mellitus: a mediated mendelian randomization analysis using plasma proteomics

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 27, 2025

With the rapid advancement of proteomics, numerous scholars have investigated intricate relationships between plasma proteins and various diseases. Therefore, this study aims to elucidate relationship BDH1 type 2 diabetes using Mendelian randomization (MR) identify novel targets for prevention treatment through proteomics. This primarily employed Randomization method, leveraging genetic data from large-scale, publicly accessible genome-wide association studies (GWAS). Within framework, we adopted a two-step, two-sample MR approach evaluate BDH1, proteins, diabetes. Finally, conducted bidirectional analyses along with sensitivity ensure robustness reliability findings. The inverse variance weighted (IVW) analysis demonstrated that each 1 standard deviation (SD) increase in risk decreased by 3% (OR: 0.97; 95% CI: 0.95, 0.99). Concurrently, proteomics-based identified 37 associated 27 BDH1. Notably, NBN, ARG1, CCL11 were found mediate protective effect on Our research findings uncovered potential several disease. These results open new avenues enhanced exploration

Язык: Английский

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Mediating Mendelian randomization in the proteome identified potential drug targets for obesity-related allergic asthma

Hereditas, Год журнала: 2025, Номер 162(1)

Опубликована: Фев. 1, 2025

With the development of economy, number obese patients has been increasing annually worldwide. The proportion asthma associated with obesity is also gradually rising. However, pathogenesis obesity-related remains incompletely understood, and conventional pharmacological treatments generally show limited efficacy. This study aims to explore causal relationship between allergic asthma, elucidate identify plasma proteins involved in its development, providing new insights for clinical interventions. In this study, we employed a two-step approach mediation Mendelian randomization (MR) analysis, utilizing stringent selection criteria instrumental variables (IVs). was used assess impact on validate identified as mediating factors. We further explored functions enriched pathways using Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analyses. Finally, conducted drug-targeted MR analysis evaluate potential each mediator drug target gene. If significant heterogeneity remained among IVs, applied weighted median method primary analytical tool. Otherwise, utilized inverse variance (IVW) main approach. Additionally, various sensitivity analyses statistical tests illustrate robustness observed associations. research findings indicate asthma. Plasma such TPST1, ROR1, DAPK1 mediate relationship, TPST1 accounting over 10% effect. GO KEGG that genes corresponding these are primarily related responses stimuli, carbohydrate synthesis metabolism, regulation certain protein activities, synaptic connections. suggests SIGLEC12, BOLA1, HOMER2, all have be genes. defined by BMI may promote influencing expression DAPK1. Furthermore, some proteins, including could potentially serve therapeutic targets treating patients. needed their mechanisms underlying effects. Not applicable.

Язык: Английский

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Genetic determinants of inflammatory cytokines and their causal relationship with inflammatory disorders of breast: a two-sample Mendelian randomization study

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 1, 2025

This study utilized two-sample MR to investigate causality between genetically predicted inflammatory markers and the risk of IDB. research leveraged publicly available GWAS summary statistics collect data on cytokines The IVW method was primarily employed for causal inference, supplemented by weighted median, mode-based estimation, MR-Egger regression. Stringent sensitivity methods included Cochran's Q test, regression, MR-PRESSO, leave-one-out analyses assess robustness findings. selected 452 instrument variables (IVs) related factors. analysis revealed that GROa RANTES/CCL5 exhibited relationships with Additionally, after removing outliers, significant associations were observed IL-1ra IL-9. Notably, IL-9 IBD remained FDR correction. Upon integrating findings from all analyses, it is unlikely heterogeneity pleiotropy substantially influenced relationships, underscoring our Our identified roles specific such as GROa, RANTES/CCL5, in development These deepen understanding complex regulatory mechanisms involving inflammation breast diseases suggest directions future biological pathways linking

Язык: Английский

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Associations between vitiligo and allergic diseases: a bidirectional two-sample Mendelian randomization study

Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)

Опубликована: Апрель 19, 2025

Язык: Английский

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Mendelian randomization analysis unveils causal relationships between skin microbiota and osteomyelitis

Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)

Опубликована: Июнь 4, 2025

Язык: Английский

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