Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Июнь 7, 2024
Helicobacter pylori ( H. ) is a strict microaerophilic bacterial species that exists in the stomach, and infection one of most common chronic infections affecting humans. Eradicating preferred method for long-term prevention complications such as gastritis, peptic ulcers, gastric mucosa-associated lymphoid tissue lymphoma, cancer. However, first-line treatment with triple therapy quadruple has been unable to cope increasing antibacterial resistance. To provide an updated review resistance, well related options, we searched PubMed articles published until March 2024. The key search terms were “ ”, infection”, diseases”, eradication”, resistance.” Despite use antimicrobial agents, annual decline eradication rate continues. Emerging therapies, development new strong acid blocker vonoprazan, probiotic adjuvant therapy, vaccine are exciting. effectiveness these treatments needs be further evaluated. It worth mentioning idea altering oxygen environment juice not able survive hot topic should considered plans. Various strategies eradicating , including antibacterials, vaccines, probiotics, biomaterials, continuously evolving. A novel approach involving alteration concentration within growth emerged promising strategy.
Язык: Английский
Процитировано
12From lab to nature: Recent advancements in the journey of gastroprotective agents from medicinal chemistry to phytotherapy
European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 272, С. 116436 - 116436
Опубликована: Апрель 23, 2024
Язык: Английский
Процитировано
11Piperine: an emerging biofactor with anticancer efficacy and therapeutic potential
BioFactors, Год журнала: 2024, Номер unknown
Опубликована: Окт. 28, 2024
Abstract Anticancer drug discovery needs serious attention to overcome the high mortality rate caused by cancer. There are still many obstacles treating this disease, such as cost of chemotherapeutic drugs, resulting side effects from drug, and occurrence multidrug resistance. Herbaceous plants a reservoir natural compounds that can be anticancer drugs with novel mechanisms action. Piperine, bioactive compound derived Piper species, is gaining due its unique dual role in directly inhibiting tumor growth enhancing bioavailability drugs. Unlike conventional treatments, Piperine exhibits mechanism action modulating multiple signaling pathways, including apoptosis autophagy, low toxicity. Additionally, acts bioenhancer improving absorption effectiveness other agents, reducing required dosage, minimizing effects. Therefore, review aims visualize summary sources, phytochemistry, chemical structure–anticancer activity relationship, activities semi‐synthetic derivatives, pharmacokinetic bioavailability, vitro vivo preclinical studies, antitumor action, human clinical trials, toxicity, effects, safety Piperine. References were collected Pubmed/MedLine database ( https://pubmed.ncbi.nlm.nih.gov/ ) following keywords: “Piperine anticancer,” derivatives,” mechanism” bioavailability,” after filter process inclusion exclusion criteria, 101 selected 444 articles. From 2013 2023, there numerous studies regarding various cell lines, breast cancer, prostate lung melanoma, cervical gastric osteosarcoma, colon hepatocellular carcinoma, ovarian leukemia, colorectal hypopharyngeal carcinoma. In vivo, study has also been conducted on some animal models, Ehrlich carcinoma‐bearing mice, ascites carcinoma cells‐bearing Balbc Wistar rat, A375SM A375P SNU‐16 BalbC HGC‐27‐bearing baby mice. Treatment leads proliferation inhibition induction apoptosis. used for trials diseases, but no cancer patient report exists. Various derivatives show efficacy an across lines. shows promise use either standalone treatment or bioenhancer. Its properties may enhance existing providing valuable foundation developing new therapies.
Язык: Английский
Процитировано
9Immunomodulatory Effects of Selected Non-Nutritive Bioactive Compounds and Their Role in Optimal Nutrition
Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(2), С. 89 - 89
Опубликована: Янв. 31, 2025
The contemporary approach to nutrition increasingly considers the role of non-nutritive bioactive compounds in modulating immune system and maintaining health. This article provides up-to-date insight into immunomodulatory effects selected compounds, including micro- macronutrients, vitamins, as well other health-promoting substances, such omega-3 fatty acids, probiotics, prebiotics, postbiotics (including butyric acid sodium butyrate), coenzyme Q10, lipoic acid, plant-derived components phenolic flavonoids, coumarins, alkaloids, polyacetylenes, saponins, carotenoids, terpenoids. Micro- zinc, selenium, magnesium, iron, play a pivotal regulating response protecting against oxidative stress. Vitamins, especially vitamins C, D, E, B, are vital for optimal functioning they facilitate production cytokines, differentiation immunological cells, neutralization free radicals, among functions. Omega-3 acids exhibit strong anti-inflammatory enhance cell function. Probiotics, modulate intestinal microbiota, thereby promoting integrity barrier communication between microbiota system. Coenzyme renowned its antioxidant attributes, participates protection cells from stress promotes energy processes essential Sodium butyrate regeneration epithelium, which is crucial maintenance homeostasis. emphasizes necessity an integrative that not only nutritional but also non-nutritional provide adequate support Without them, will never function properly, because it has been adapted this course evolution. data presented may serve foundation further research potential applications prevention treatment diseases associated with dysfunction.
Язык: Английский
Процитировано
0Non-antibiotic therapies for multidrug-resistant gastrointestinal infections: an overview of the use of probiotics, natural compounds, and bacteriophages
Frontiers in Antibiotics, Год журнала: 2025, Номер 4
Опубликована: Май 6, 2025
The worldwide increasing frequency and severity of multidrug-resistant gastrointestinal (MDR-GI) infections not only raises awareness the debilities conventional antibiotic treatments but also highlights demand for alternative interventions. One these alternatives is probiotics, harmless bacteria that compete with pathogenic species, which have been considered beneficial due to their therapeutic potential since they strengthen mucosal barrier modulate host immune response. Other natural compounds (e.g., polyphenols, flavonoids, essential oils) present diverse antimicrobial mechanisms, are promising mitigate resistant pathogens. Finally, bacteriophages, viruses target specific bacteria, constitute a precise approach in MDR lysed or disrupted by biofilms formed during colonization without compromising normal gut microbiome. Therefore, manuscript provides an integrated perspective on non-antibiotic therapies manage MDR-GI infections; this purpose, it covers aspects such as action current clinical applications, challenges limit broader application practice. combining approaches personalizing infection adjusted patients' microbiome profiles discussed, aiming enhance efficacy reduce resistance risks. importance continued research development optimize debated, addressing need surpass regulatory barriers conducting large-scale trials establish safety alternatives. This overview knowledge contributes ongoing efforts develop sustainable strategies combat global burden resistance.
Язык: Английский
Процитировано
0Bee Products in the Fight against Helicobacter Pylori and Molecular Interactions
Microbial Pathogenesis, Год журнала: 2025, Номер unknown, С. 107707 - 107707
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0Helicobacter pylori: Routes of Infection, Antimicrobial Resistance, and Alternative Therapies as a Means to Develop Infection Control
Diseases, Год журнала: 2024, Номер 12(12), С. 311 - 311
Опубликована: Дек. 3, 2024
Helicobacter pylori (H. pylori) is a Gram-negative, spiral-shaped bacterium that colonizes the gastric epithelium and associated with range of gastrointestinal disorders, exhibiting global prevalence approximately 50%. Despite availability treatment options, H. frequently reemerges demonstrates increasing antibiotic resistance, which diminishes efficacy conventional therapies. Consequently, it imperative to explore non-antibiotic alternatives mitigate inappropriate use antibiotics. This review examines infection, encompassing transmission pathways, modalities, eradication strategies. Additionally, discusses alternative therapeutic approaches such as probiotics, anti-biofilm agents, phytotherapy, phototherapy, phage therapy, lactoferrin vaccine development. These strategies aim reduce antimicrobial resistance enhance outcomes for infections. While therapies can maintain low bacterial levels, they do not achieve complete pylori. are designed bolster immune response, minimize side effects, provide gastroprotective benefits, rendering them suitable adjunctive alongside treatments. Probiotics may serve therapy pylori; however, their effectiveness monotherapy limited. Photodynamic exhibit potential in targeting infections, including those caused by drug-resistant strains, without The development reliable also critical identifies candidate antigens VacA, CagA, HspA, along various formulations, vector-based subunit vaccines. Some vaccines have demonstrated clinical trials, while others shown robust protection preclinical studies. Nevertheless, each aforementioned requires thorough evaluation ascertain efficacy, cost-effectiveness, patient compliance.
Язык: Английский
Процитировано
1Gastrointestinal Ulcers Treatment: Plants and Recipes Used by Herbalists of Abomey-Calavi and Cotonou Districts, Southern Benin
American Journal of Plant Sciences, Год журнала: 2024, Номер 15(09), С. 699 - 725
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0Natural Product-Based Treatment for Gastritis
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
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