VFDB 2025: an integrated resource for exploring anti-virulence compounds
Nucleic Acids Research,
Год журнала:
2024,
Номер
53(D1), С. D871 - D877
Опубликована: Окт. 29, 2024
Abstract
With
the
escalating
crisis
of
bacterial
multidrug
resistance,
anti-virulence
therapeutic
strategies
have
emerged
as
a
highly
promising
alternative
to
conventional
antibiotic
treatments.
Anti-virulence
compounds
are
specifically
designed
target
virulence
factors
(VFs),
disarming
pathogens
without
affecting
growth
and
thus
reduce
selective
pressure
for
resistance
development.
However,
due
complexity
pathogenesis,
no
small
molecules
been
approved
clinical
use
far,
despite
documentation
hundreds
potential
candidates.
To
provide
valuable
reference
resources
drug
design,
repurposing,
selection,
factor
database
(VFDB,
http://www.mgc.ac.cn/VFs/)
has
systematically
collected
public
data
on
through
extensive
literature
mining,
further
integrated
this
information
with
its
existing
knowledge
VFs.
date,
VFDB
curated
comprehensive
dataset
902
across
17
superclasses
reported
by
262
studies
worldwide.
By
cross-linking
current
VFs
relevant
(e.g.
classification,
chemical
structure,
molecular
targets
mechanisms
action),
aims
bridge
gap
between
chemists
microbiologists,
providing
crucial
insights
development
innovative
effective
antibacterial
therapies
combat
infections
address
resistance.
Язык: Английский
Chalcone derivative enhance poultry meat preservation through quorum sensing inhibition against Salmonella (Salmonella enterica serovar Typhi) contamination
Food Control,
Год журнала:
2025,
Номер
unknown, С. 111155 - 111155
Опубликована: Янв. 1, 2025
Nanoenabling MbtI Inhibitors for Next-Generation Tuberculosis Therapy
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
The
urgent
need
for
safer
and
innovative
antitubercular
agents
remains
a
priority
the
scientific
community.
In
pursuit
of
this
goal,
we
designed
evaluated
novel
5-phenylfuran-2-carboxylic
acid
derivatives
targeting
Mycobacterium
tuberculosis
(Mtb)
salicylate
synthase
(MbtI),
key
enzyme,
absent
in
humans,
that
plays
crucial
role
Mtb
virulence.
Several
potent
MbtI
inhibitors
demonstrating
significant
activity
favorable
safety
profile
were
identified.
Structure-guided
optimization
yielded
5-(3-cyano-5-isobutoxyphenyl)furan-2-carboxylic
(1e),
which
exhibited
strong
inhibition
(IC50
=
11.2
μM)
promising
vitro
(MIC99
32
μM
against
M.
bovis
BCG).
Esters
1e
effectively
loaded
into
poly(2-methacryloyloxyethyl
phosphorylcholine)-poly(2-(diisopropylamino)ethyl
methacrylate)
(PMPC-PDPA)
polymersomes
(POs)
delivered
to
intracellular
mycobacteria,
resulting
reduced
viability.
This
study
provides
foundation
use
POs
development
future
MbtI-targeted
therapies
tuberculosis.
Язык: Английский
Functionalization of cationic porphyrins with peripheral platinum(II) complexes to optimize photodynamic therapy against Candida- associated infections: a focus on denture stomatitis and burn wounds
Mycology: An International Journal on Fungal Biology,
Год журнала:
2025,
Номер
unknown, С. 1 - 20
Опубликована: Март 11, 2025
Язык: Английский
Therapeutic effect and concomitant toxicity of Hydrargyrum Chloratum Compositum on chronic difficult-to-heal wounds in rats
Journal of Ethnopharmacology,
Год журнала:
2025,
Номер
unknown, С. 119749 - 119749
Опубликована: Апрель 1, 2025
Язык: Английский
New Methodologies as Opportunities in the Study of Bacterial Biofilms, Including Food-Related Applications
Microorganisms,
Год журнала:
2025,
Номер
13(5), С. 1062 - 1062
Опубликована: Май 2, 2025
Traditional
food
technologies,
while
essential,
often
face
limitations
in
sensitivity,
real-time
detection,
and
adaptability
to
complex
biological
systems
such
as
microbial
biofilms.
These
constraints
have
created
a
growing
demand
for
more
advanced,
precise,
non-invasive
tools
ensure
safety
quality.
In
response
these
challenges,
cross-disciplinary
technological
integration
has
opened
new
opportunities
the
industry
public
health,
leveraging
methods
originally
developed
other
scientific
fields.
Although
their
industrial-scale
implementation
is
still
evolving,
application
research
pilot
settings
already
significantly
improved
our
ability
detect
control
biofilms,
thereby
strengthening
protocols.
Advanced
analytical
techniques,
identification
of
pathogenic
species
virulence
markers,
screening
“natural”
antimicrobial
compounds
can
now
be
conceptualized
interconnected
elements
within
virtual
framework
centered
on
“food”
“biofilm”.
this
short
review,
starting
from
basic
concepts
biofilm
associated
microorganisms,
we
highlight
selection
emerging
approaches—from
optical
methods,
microfluidics,
Atomic
Force
Microscopy
(AFM),
biospeckle
techniques
molecular
strategies
like
CRISPR,
qPCR,
NGS,
use
organoids.
Initially
conceived
biomedical
biotechnological
applications,
recently
demonstrated
value
science
by
enhancing
understanding
behavior
supporting
discovery
novel
anti-biofilm
strategies.
Язык: Английский
A multi-computational and crystallographic investigation for the antibiotic mechanism of two 2,4-bis(4-methoxyphenamino)pyrimidines
Journal of Molecular Structure,
Год журнала:
2024,
Номер
unknown, С. 140358 - 140358
Опубликована: Окт. 1, 2024
Язык: Английский
Toward Mycobacterium tuberculosis Virulence Inhibition: Beyond Cell Wall
Microorganisms,
Год журнала:
2024,
Номер
13(1), С. 21 - 21
Опубликована: Дек. 26, 2024
Mycobacterium
tuberculosis
(Mtb)
is
one
of
the
most
successful
bacterial
pathogens
in
human
history.
Even
antibiotic
era,
Mtb
widespread
and
causes
millions
new
cases
each
year.
The
ability
to
disrupt
host's
innate
adaptive
immunity,
as
well
natural
persistence,
complicates
disease
control.
Tuberculosis
traditional
therapy
involves
long-term
use
several
antibiotics.
Treatment
failures
are
often
associated
with
development
resistance
or
more
drugs.
medicines
that
act
on
targets
will
expand
treatment
options
for
caused
by
multidrug-resistant
extensively
drug-resistant
Mtb.
Therefore,
drugs
target
virulence
factors
an
attractive
strategy.
Such
do
not
have
a
direct
bacteriostatic
bactericidal
effect,
but
can
disarm
pathogen
so
host
immune
system
becomes
able
eliminate
it.
Although
cell
wall-associated
being
actively
studied
anti-TB
drug
development,
other
important
adaptation
interaction
also
worth
comprehensive
analysis.
In
this
review,
specific
(such
secreted
phosphatases,
regulatory
systems,
ESX-1
secretion
system)
identified
promising
novel
anti-virulence
development.
Additionally,
models
search
inhibitors
discussed,
such
virtual
screening
silico,
vitro
enzyme
inhibition
assay,
recombinant
strains
reporter
constructs,
phenotypic
analysis
using
infection
environments.
Язык: Английский