Mapping the relationship between alcohol use disorder and gut microbiota: a 20-year bibliometric study
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 18, 2024
Background
Alcohol
use
disorder
(AUD)
is
a
psychiatric
that
widespread
worldwide.
significant
contributor
to
the
global
burden
of
death,
disability
and
disease.
Modulation
gut
microbiota
promising
approach
improve
efficacy
minimize
adverse
effects
colorectal
cancer
treatment.
The
relationship
between
presence
microbes
AUD
has
been
widely
validated.
However,
few
studies
have
examined
this
using
bibliometric
methods.
Therefore,
study
analyzes
research
hotspots
trends
in
human
microbiology
over
last
two
decades
from
perspective.
This
aims
at
provide
new
directions
for
basic
clinical
field.
Objective
A
comprehensive
discussion
current
state
intestinal
flora.
Methods
We
collected
publications
Web
Science
Core
Collection
database
2003
2023
according
established
inclusion
criteria.
analyzed
countries,
institutions,
authors,
contributions
CiteSpace,
VOSviewer,
Scimago
Graphics
visualize
Results
total
2,102
were
obtained,
with
rapid
increase
number
since
2016.
United
States
China
are
major
contributors
field
network
partners
several
countries.
Five
hundred
ninety-five
academic
journals
published
articles
on
topic.
author
highest
Prof.
Bernd
Schnabl
Department
Gastroenterology
University
California,
San
Diego.
In
addition
“gut
flora”
“AUD,”
high
frequency
words
keyword
co-occurrence
analysis
included
alcoholic
liver
disease,
tryptophan
metabolism,
enterohepatic
axis,
fecal
microbial
transplantation.
Conclusion
results
visualization
key
areas
past
20
years.
suggest
role
its
potential
mechanisms,
especially
therapeutic
targets,
should
be
closely
monitored
could
become
hot
topic
Язык: Английский
The influence of metformin and empagliflozin administration on gut microbiota in individuals with type 2 diabetes mellitus and hypothyroidism
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine),
Год журнала:
2024,
Номер
20(4), С. 292 - 296
Опубликована: Авг. 2, 2024
Background.
There
is
a
lack
of
studies
focusing
on
the
combined
impact
metformin,
empagliflozin,
and
levothyroxine
gut
microbiota
in
patients
with
type
2
diabetes
mellitus
(T2DM)
hypothyroidism.
The
purpose
study
was
to
examine
how
combination
metformin
empagliflozin
affects
composition
Materials
methods.
We
enrolled
47
who
have
been
receiving
hormone
replacement
therapy
at
stable
dose
over
past
years
were
newly
diagnosed
T2DM.
All
participants
divided
into
two
groups
received
either
alone
or
plus
for
6
months.
Metabolic
hormonal
parameters
measured
before
after
treatment,
stool
samples
analyzed
using
PCR
sequencing.
Results.
found
that
both
groups,
there
an
improvement
carbohydrate
metabolism,
lipid
profile,
liver
transaminases
treatment.
group
treated
had
more
significant
reduction
glucose,
glycated
hemoglobin,
atherogenicity
coefficient
than
alone.
also
resulted
lower
levels
Firmicutes
increase
number
Actinobacteria,
as
well
higher
ratio
Bacteroides
fragilis
Faecalibacterium
prausnitzii.
Conclusions.
shows
first
time
can
directly
affect
T2DM
These
changes
may
be
necessary
treating
this
cohort
require
further
investigation.
Язык: Английский
Testosterone treatment impacts the intestinal microbiome of transgender individuals
mSphere,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
ABSTRACT
Medical
modulation
of
sex
hormone
levels
is
a
cornerstone
treatment
for
many
conditions
that
impact
well-being,
including
cancer,
fertility/infertility,
gender
dysphoria,
and
chronic
metabolic
diseases
such
as
diabetes
obesity.
The
microbial
residents
the
intestine,
known
microbiota,
interact
with
hormones
in
there
correlative
evidence
this
interaction
bidirectional.
Based
on
these
published
findings,
we
hypothesized
transgender
individuals
receiving
exogenous
testosterone
part
their
gender-affirming
medical
might
undergo
changes
intestinal
microbiome.
To
test
this,
collected
26
stool
samples
from
nine
before
up
to
8
months
after
initiation
subjected
metagenomic
analysis.
While
no
species
were
significantly
associated
duration
therapy,
pathways
generate
glutamate
increased
abundance,
while
those
consume
decreased.
Glutamate
precursor
arginine,
increase
arginine
its
metabolites
plasma.
We
hypothesize
increases
uptake
by
enterocytes,
thus
decreasing
access
microbiota
amino
acid.
pilot
study
establishes
therapy
microbiome,
more
comprehensive
necessary
establish
testosterone-driven
shifts
metatranscriptome,
metabolome,
plasma
metabolome.
IMPORTANCE
human
intestine
inhabited
large
community
microbes
Members
microbiome
diet
along
host.
Thus,
metabolomes
host
microbe
are
intricately
linked.
Testosterone
alters
In
particular,
positively
correlated.
investigate
analyzed
metagenomes
treatment.
project,
found
modest
structure
but
an
abundance
spare
consumption.
propose
uses
amount
available
Язык: Английский
Genetically Predicted Blood Metabolites Mediate the Association Between Gut Microbiota and Childhood with obesity: A Mendelian Randomization Study
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 23, 2024
Summary
Background
Childhood
with
obesity
is
characterized
by
metabolic
dysregulation
and
unique
gut
microbiota
profiles.
Nevertheless,
the
comprehensive
understanding
of
remains
unclear.
Objectives
This
study
aimed
to
investigate
causal
relationship
identify
blood
metabolites
as
potential
mediators.
Methods
The
exposure
genome-wide
association
studies
(GWAS)
data
were
sourced
from
GWAS
Catalog,
while
outcome
obtained
Early
Growth
Genetics
(EGG)
Consortium.
used
473
types
microbiota,
233
metabolites,
GWAS.
We
then
performed
two-sample
Mendelian
randomization
(TSMR)
bidirectional
(BDMR)
analyses
explore
relationships
between
obesity.
Additionally,
we
conducted
multivariable
(MVMR)
two-step
(2SMR)
mediating
in
this
process.
Results
MR
analysis
identified
13
12
that
causally
associated
Furthermore,
there
was
no
strong
evidence
genetically
predicted
had
an
effect
on
these
metabolites.
Further,
2SMR
revealed
K10
sp001941205
mediated
Total
cholesterol
total
lipids
ratio
medium
VLDL,
accounting
for
2.53%
(95%CI;
2.14%-2.92%)
association.
Similarly,
SM23-33
Ratio
22:6
docosahexaenoic
acid
fatty
acids,
which
accounted
4.07%
2.70%-5.44%)
Conclusions
present
first
among
phenotypes,
through
analysis,
identifying
links
suggesting
2
may
mediate
associations,
thereby
providing
valuable
insights
future
intervention
strategies
at
addressing
Язык: Английский