Sequential Therapy of Linezolid and Contezolid to Treat Hematogenous Lung Abscess Caused by Staphylococcus aureus in a Congenital Cerebral Hypoplasia Patient: A Case Report
Infection and Drug Resistance,
Год журнала:
2025,
Номер
Volume 18, С. 253 - 260
Опубликована: Янв. 1, 2025
Staphylococcus
aureus
is
a
common
pathogen
of
hematogenous
lung
abscesses.
The
increased
resistance
S.
to
antibiotics
makes
infections
difficult
treat,
often
resulting
in
poor
prognosis.
Therefore,
it
important
identify
as
early
possible
and
evaluate
its
sensitivity
antibiotics,
formulate
an
appropriate
treatment
plan.
Oxazolidinone
exhibit
potent
antibacterial
activity
against
multidrug-resistant
(MDR)
aureus;
however,
the
adverse
effects
linezolid,
particularly
thrombocytopenia,
limit
application.
Contezolid
may
ameliorate
hematologic
toxicity
associated
with
linezolid.
Here,
we
report
case
patient
congenital
cerebral
hypoplasia
who
was
hospitalized
due
fever
multiple
abscesses
both
lungs.
In
context
negative
blood
culture
results,
final
diagnosis
MDR
causative
agent
abscess
confirmed
using
macrogenomic
next-generation
sequencing
(mNGS)
targeted
(tNGS).
treated
linezolid
but
developed
significant
so
switching
sequential
therapy
contezolid,
patient's
platelet
counts
returned
normal
his
condition
improved
significantly.
Язык: Английский
Acute Necrotizing Fasciitis Caused by Rhizopus Infection in a Patient with Diabetes and Pulmonary Tuberculosis: A Case Report
Xiaoqing Huang,
Junke Qiu,
Lei Pan
и другие.
Infection and Drug Resistance,
Год журнала:
2025,
Номер
Volume 18, С. 775 - 782
Опубликована: Фев. 1, 2025
Background:
Zygomycosis,
also
termed
mucormycosis,
is
a
rare
yet
highly
fatal
fungal
infection
caused
by
Mucorales
species,
notably
Rhizopus
spp.
Case
Presentation:
This
case
study
details
72-year-old
man
with
diabetes,
pulmonary
tuberculosis,
and
nephrotic
syndrome
who
developed
acute
necrotizing
fasciitis
attributable
to
R.
oryzae
.
Despite
initial
empirical
antibiotic
therapy,
the
progressed
rapidly.
Metagenomic
next-generation
sequencing
(mNGS)
facilitated
swift
diagnosis,
identifying
in
blood
drainage
samples.
The
treatment
included
amphotericin
B
isavuconazole,
along
aggressive
surgical
debridement.
patient
exhibited
substantial
improvement,
he
was
discharged
after
stabilization.
Conclusion:
highlights
critical
role
of
early
diagnosis
through
mNGS
need
for
multidisciplinary
approach
manage
severe
mucormycosis
immunocompromised
patients.
Keywords:
infection,
fasciitis,
report
Язык: Английский
Rhino-Orbital-Cerebral Mucormycosis in diabetic ketoacidosis: A Classic Clinical Presentation still unknown in Senegal
IDCases,
Год журнала:
2025,
Номер
40, С. e02244 - e02244
Опубликована: Янв. 1, 2025
Rhino-orbital-cerebral
mucormycosis
(ROCM)
is
an
invasive
mycosis
caused
by
fungi
of
the
order
Mucorales.
It
mainly
affects
patients
with
uncontrolled
diabetes.
This
case
report
concerns
a
27-year-old
woman
diabetic
ketoacidosis
who
presented
large
erythematous
plaque
localised
in
right
orbitofrontal
region
exophthalmos
and
patches
necrosis
that
rapidly
led
to
death
within
3
days
before
diagnosis
ROCM
due
Rhizopus
oryzae,
causal
agent.
So,
without
rapid
swift
management,
results
potential
fatality.
Язык: Английский
Comparative Study of Periocular Fat Tissue Concentrations Following Retrobulbar, Intravenous, and Combined Retrobulbar-Intravenous Injection of Liposomal Amphotericin B in Rats
Journal of Kermanshah University of Medical Sciences,
Год журнала:
2024,
Номер
28(4)
Опубликована: Ноя. 29, 2024
Background:
Recently,
retrobulbar
injection
of
liposomal
amphotericin
B
has
been
explored
as
an
alternative
treatment
rhino-orbital-cerebral
mucormycosis.
Objectives:
This
study
aims
to
measure
concentration
in
the
periocular
fat
tissue
following
intravenous,
retrobulbar,
and
combined
intravenous
injections.
Methods:
In
this
study,
45
rats
were
divided
into
15
groups,
receiving
either
or
Three
groups
received
same
dose
B.
Rats
sacrificed
at
4-,
6-,
24-hours
post-injection
was
analyzed
for
using
HPLC.
Results:
Results
showed
that
concentrations
after
10
mg/kg
0.0001,
0.1154,
0.0693
μg/mL
4,
6,
24
hours,
respectively;
mg/kg,
0.0339,
0.3534,
0.4209
μg/mL.
Retrobulbar
resulted
8.8965,
9.8124,
9.4156
Combined
injections
(10
IV
+
0.25
retrobulbar)
yielded
8.8401,
7.8869,
8.6409
μg/mL,
while
8.1940,
8.5277,
9.0889
Conclusions:
The
findings
indicate
achieves
suitable
drug
tissue,
suggesting
mucormycosis,
alone
may
be
sufficient,
potentially
eliminating
need
administration.
Язык: Английский
Pulmonary mucormycosis in an immunocompetent young female: a case report and literature review
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Дек. 24, 2024
Mucormycosis
is
considered
a
rare
but
highly
lethal
fungal
infection,
often
occurring
in
patients
with
poorly
controlled
diabetes
or
immunosuppression.
Pulmonary
mucormycosis
progresses
rapidly
and
associated
pulmonary
infarction
hemoptysis.
In
this
case
report,
we
presented
young,
immunocompetent
female
patient
newly
diagnosed
who
was
early
Rhizopus
delemar
infection
through
metagenomic
next-generation
sequencing.
Despite
diagnosis,
the
progressed
rapidly,
invading
tracheal
cartilage
upper
mediastinal
soft
tissue,
ultimately
leading
to
patient’s
unfortunate
demise.
Язык: Английский