Future Microbiology, Год журнала: 2024, Номер unknown, С. 1 - 3
Опубликована: Дек. 5, 2024
Язык: Английский
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Июль 31, 2024
Millions of microorganisms make up the complex microbial ecosystem found in human gut. The immune system's interaction with gut microbiota is essential for preventing inflammation and maintaining intestinal homeostasis. Numerous metabolic products that can cross-talk between cells epithelium are metabolized by microbiota. Traumatic injury elicits a great multifaceted response minutes after initial offense, containing simultaneous pro- anti-inflammatory responses. development innovative therapies improve patient outcomes depends on immunological responses to trauma. altered makeup microbes, or dysbiosis, also dysregulate responses, resulting inflammation. Major diseases may become more common as result chronic dysbiosis translocation bacteria their metabolism beyond mucosal barrier. In this review, we briefly summarize interactions system disease therapeutic probiotic formulations. We discuss traumatic injury.
Язык: Английский
Процитировано
9
Biomedicines, Год журнала: 2025, Номер 13(2), С. 329 - 329
Опубликована: Янв. 31, 2025
Nutrition, the gut microbiota and immunity are all important factors in maintenance of health. However, there is a growing realization complex interplay between these elements coalescing nutrition-gut microbiota-immunity axis. This regulatory axis critical for health with disruption being implicated broad range diseases, including autoimmune disorders, allergies mental disorders. new perspective continues to underpin number innovative therapeutic strategies targeting different this treat relevant diseases. review describes inter-relationships nutrition, immunity. It then details several human diseases where has been identified presents examples how various may be targeted therapeutically as alternate treatment
Язык: Английский
Процитировано
1
International review of cell and molecular biology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13
Опубликована: Фев. 26, 2025
The human gut microbiota, consisting of trillions microorganisms, plays a crucial role in gastrointestinal (GI) health and disease. Dysbiosis, an imbalance microbial composition, has been linked to range GI disorders, including inflammatory bowel disease (IBD), irritable syndrome (IBS), celiac disease, colorectal cancer. These conditions are influenced by the interactions between host immune system, gut-brain axis. Recent research highlighted potential for microbiome-based therapeutic strategies, such as probiotics, prebiotics, fecal microbiota transplantation (FMT), dietary modifications, restore balance alleviate symptoms. This review examines pathogenesis common diseases explores emerging approaches aimed at modulating microbiome. We discuss scientific foundations these interventions, their clinical effectiveness, challenges implementation. underscores microbiome-targeted treatments novel approach managing offering personalized alternative options conventional therapies. As this field continues evolve, interventions hold promise improving treatment prevention diseases.
Язык: Английский
Процитировано
0
Global Change Biology, Год журнала: 2025, Номер 31(4)
Опубликована: Апрель 1, 2025
ABSTRACT The various human microbiomes play critical roles in maintaining health and well‐being, they are continuously shaped by a complex web of internal external factors. Research on environmental is generally discrete within disciplinary areas such as medicine, microbiology, molecular ecology, etc. This paper presents perspective based scoping review the literature, aiming to explore how these interconnected shape well‐being and, turn, planetary health. We working from cellular mechanisms population outcomes, role intrinsic extrinsic factors influencing microbiomes. argue that global trends homogenization diets, environments, medical practices driving shifts microbial diversity, with far‐reaching implications for well Disruptions feedback at individual, community, ecosystem levels often exacerbated biodiversity loss change. underscore need holistic public interventions account microbiome stewardship across scales. By examining connections, we aim highlight importance systems‐level understanding
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2025, Номер 2(1)
Опубликована: Апрель 18, 2025
Язык: Английский
Процитировано
0
Pharmacological Research, Год журнала: 2025, Номер 216, С. 107749 - 107749
Опубликована: Апрель 28, 2025
The human gut microbiome, composed of a vast array microorganisms that have co-evolved with humans, is crucial for the development and function brain systems. Research has consistently shown bidirectional communication between through neuronal, endocrine, immunological, chemical pathways. Recent neuroscience studies linked changes in microbiome microbial metabolites to various neuropsychiatric disorders such as autism, depression, anxiety, schizophrenia, eating disorders, neurocognitive disorders. Novel metagenome-wide association confirmed these variations large samples expanded our understanding interactions genes microbiome. causal relationship microbiota being elucidated establishment cohort incorporating data advanced statistical techniques. Ongoing animal focused on microbiota-gut-brain axis are promising developing new prevention treatment strategies conditions. scope broadened from microbiome-modulating therapies including prebiotics, probiotics, synbiotics postbiotics more extensive approaches fecal transplantation. systematic reviews meta-analyses strengthened evidence base innovative treatments. Despite research over past decade, many intriguing aspects still need be regarding role therapeutic interventions
Язык: Английский
Процитировано
0
Women s Health Reports, Год журнала: 2024, Номер 5(1), С. 785 - 793
Опубликована: Апрель 1, 2024
Studies have shown that the gut microbiota of healthy men and with familial Mediterranean fever (FMF) disease respond differently to placebo. Given fact composition is different in women, this study aimed describe detail placebo response FMF women.
Язык: Английский
Процитировано
3
Microorganisms, Год журнала: 2024, Номер 12(9), С. 1866 - 1866
Опубликована: Сен. 9, 2024
Networks are widely used to represent relationships between objects, including microorganisms within ecosystems, based on high-throughput sequencing data. However, challenges arise with appropriate statistical algorithms, handling of rare taxa, excess zeros in compositional data, and interpretation. This work introduces a novel Slope-Matrix-Graph (SMG) algorithm identify microbiome correlations primarily slope-based distance calculations. SMG effectively handles any proportion data involves: (1) searching for correlated (e.g., positive negative directions changes) “target interest” setting, (2) quantifying graph changes via distances objects. Evaluations simulated datasets demonstrated SMG’s ability accurately cluster microbes into distinct positive/negative correlation groups, outperforming methods like Bray–Curtis SparCC both sensitivity specificity. Moreover, superior accuracy detecting differential abundance (DA) compared ZicoSeq ANCOM-BC2, making it robust tool analysis. A key advantage is natural capacity analyze zero-inflated without transformations. Overall, this simple yet powerful holds promise diverse analysis applications.
Язык: Английский
Процитировано
0
Future Microbiology, Год журнала: 2024, Номер unknown, С. 1 - 3
Опубликована: Дек. 5, 2024
Язык: Английский
Процитировано
0