Innate immune mechanisms of infection: what we know and potential conserved mechanisms affecting sleep during infection
Mark R. Zielinski,
Sean D. Carey,
John A. Craig
и другие.
Neurobiology of Sleep and Circadian Rhythms,
Год журнала:
2025,
Номер
unknown, С. 100121 - 100121
Опубликована: Апрель 1, 2025
Язык: Английский
Artesunate: a potential drug for the prevention and treatment from hepatitis to hepatocellular carcinoma
Pharmacological Research,
Год журнала:
2024,
Номер
unknown, С. 107526 - 107526
Опубликована: Ноя. 1, 2024
Язык: Английский
Viral Infections and the Glutathione Peroxidase Family: Mechanisms of Disease Development
Antioxidants and Redox Signaling,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 24, 2024
The
glutathione
peroxidase
(GPx)
family
is
recognized
for
its
essential
function
in
maintaining
cellular
redox
balance
and
countering
the
overproduction
of
reactive
oxygen
species
(ROS),
a
process
intricately
linked
to
progression
various
diseases
including
those
spurred
by
viral
infections.
modulation
GPx
activity
viruses
presents
critical
juncture
disease
pathogenesis,
influencing
responses
trajectory
infection-induced
diseases.
Язык: Английский
Transcriptome and single-cell profiling of the mechanism of diabetic kidney disease
World Journal of Diabetes,
Год журнала:
2024,
Номер
16(2)
Опубликована: Дек. 30, 2024
The
NOD-like
receptor
thermal
protein
domain
associated
3
(NLRP3)
inflammasome
may
play
an
important
role
in
diabetic
kidney
disease
(DKD).
However,
the
exact
link
remains
unclear.
To
investigate
of
NLRP3
DKD.
Using
datasets
from
Gene
Expression
Omnibus
database,
30
inflammasome-related
genes
were
identified.
Differentially
expressed
selected
using
differential
expression
analysis,
whereas
intersecting
based
on
overlapping
differentially
and
genes.
Subsequently,
three
machine
learning
algorithms
used
to
screen
genes,
biomarkers
identified
by
algorithms.
Potential
validated
western
blotting
a
db/db
mouse
model
diabetes.
Two
biomarkers,
sirtuin
2
(SIRT2)
caspase
1
(CASP1),
involved
Leishmania
infection
pathway
Both
endothelial
cells.
Pseudo-temporal
analysis
cells
showed
that
DKD
mostly
occurs
during
mid-differentiation
stage.
Western
results
CASP1
was
higher
group
than
control
(P
<
0.05),
SIRT2
content
decreased
0.05).
provide
potential
theoretical
basis
for
treatment.
Язык: Английский