Transcriptome and single-cell profiling of the mechanism of diabetic kidney disease DOI
Ying Zhou, Xiao Fang,

Linjing Huang

и другие.

World Journal of Diabetes, Год журнала: 2024, Номер 16(2)

Опубликована: Дек. 30, 2024

The NOD-like receptor thermal protein domain associated 3 (NLRP3) inflammasome may play an important role in diabetic kidney disease (DKD). However, the exact link remains unclear. To investigate of NLRP3 DKD. Using datasets from Gene Expression Omnibus database, 30 inflammasome-related genes were identified. Differentially expressed selected using differential expression analysis, whereas intersecting based on overlapping differentially and genes. Subsequently, three machine learning algorithms used to screen genes, biomarkers identified by algorithms. Potential validated western blotting a db/db mouse model diabetes. Two biomarkers, sirtuin 2 (SIRT2) caspase 1 (CASP1), involved Leishmania infection pathway Both endothelial cells. Pseudo-temporal analysis cells showed that DKD mostly occurs during mid-differentiation stage. Western results CASP1 was higher group than control (P < 0.05), SIRT2 content decreased 0.05). provide potential theoretical basis for treatment.

Язык: Английский

Innate immune mechanisms of infection: what we know and potential conserved mechanisms affecting sleep during infection DOI Creative Commons

Mark R. Zielinski,

Sean D. Carey,

John A. Craig

и другие.

Neurobiology of Sleep and Circadian Rhythms, Год журнала: 2025, Номер unknown, С. 100121 - 100121

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

1
Artesunate: a potential drug for the prevention and treatment from hepatitis to hepatocellular carcinoma DOI Creative Commons
Xinyue Liu, Yilin Cai, Yuanhao Zhang

и другие.

Pharmacological Research, Год журнала: 2024, Номер unknown, С. 107526 - 107526

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

1
Viral Infections and the Glutathione Peroxidase Family: Mechanisms of Disease Development DOI
Qingqing Lu, Yuan Ding, Wen Liu

и другие.

Antioxidants and Redox Signaling, Год журнала: 2024, Номер unknown

Опубликована: Окт. 24, 2024

The glutathione peroxidase (GPx) family is recognized for its essential function in maintaining cellular redox balance and countering the overproduction of reactive oxygen species (ROS), a process intricately linked to progression various diseases including those spurred by viral infections. modulation GPx activity viruses presents critical juncture disease pathogenesis, influencing responses trajectory infection-induced diseases.

Язык: Английский

Процитировано

0
Transcriptome and single-cell profiling of the mechanism of diabetic kidney disease DOI
Ying Zhou, Xiao Fang,

Linjing Huang

и другие.

World Journal of Diabetes, Год журнала: 2024, Номер 16(2)

Опубликована: Дек. 30, 2024

The NOD-like receptor thermal protein domain associated 3 (NLRP3) inflammasome may play an important role in diabetic kidney disease (DKD). However, the exact link remains unclear. To investigate of NLRP3 DKD. Using datasets from Gene Expression Omnibus database, 30 inflammasome-related genes were identified. Differentially expressed selected using differential expression analysis, whereas intersecting based on overlapping differentially and genes. Subsequently, three machine learning algorithms used to screen genes, biomarkers identified by algorithms. Potential validated western blotting a db/db mouse model diabetes. Two biomarkers, sirtuin 2 (SIRT2) caspase 1 (CASP1), involved Leishmania infection pathway Both endothelial cells. Pseudo-temporal analysis cells showed that DKD mostly occurs during mid-differentiation stage. Western results CASP1 was higher group than control (P < 0.05), SIRT2 content decreased 0.05). provide potential theoretical basis for treatment.

Язык: Английский

Процитировано

0