International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139254 - 139254
Опубликована: Дек. 1, 2024
Язык: Английский
Viruses, Год журнала: 2025, Номер 17(1), С. 98 - 98
Опубликована: Янв. 14, 2025
Post-acute sequelae of COVID-19 (PASC) are a diverse set symptoms and syndromes driven by dysfunction multiple organ systems that can persist for years negatively impact the quality life millions individuals. We currently lack specific therapeutics patients with PASC, due in part to an incomplete understanding its pathogenesis, especially non-pulmonary sequelae. Here, we discuss three animal models have been utilized investigate PASC: non-human primates (NHPs), hamsters, mice. focus on neurological, gastrointestinal, cardiovascular PASC highlight advances mechanistic insight made using these models, as well discussing warrant continued intensive research.
Язык: Английский
Процитировано
0
Zeitschrift für Naturforschung C, Год журнала: 2025, Номер unknown
Опубликована: Фев. 8, 2025
Abstract The research examined the molecular interaction between nirmatrelvir (NIR), a drug used to treat COVID-19, and human serum albumin (HSA) using various techniques, viz. , isothermal titration calorimetry (ITC), absorption, fluorescence, CD spectroscopy, atomic force microscopy (AFM). ITC analysis showed that NIR–HSA system possessed moderate binding affinity, with K value of 6.53 ± 0.23 × 10 4 M −1 at temperature 300 K. thermodynamic values demonstrated complex was stabilized by hydrophobic contacts, hydrogen bonds, van der Waals forces. also discovered modifications in UV–Vis absorption spectrum protein as well swelling HSA molecule when exposed NIR, based on AFM results. three-dimensional fluorescence spectral data indicated changes microenvironment around HSA’s Trp Tyr residues. Alterations structure (both secondary tertiary structures) after NIR were verified studies far-UV near-UV regions. identification site subdomain IB (Site III) predicted through competitive displacement experiments.
Язык: Английский
Процитировано
0
Current Medical Research and Opinion, Год журнала: 2025, Номер unknown, С. 1 - 35
Опубликована: Март 17, 2025
Introduction While the impact of COVID-19 on bone metabolism has been extensively studied, inverse relationship remains less understood. This study investigates whether impaired is associated with an increased risk infection.
Язык: Английский
Процитировано
0
COVID, Год журнала: 2025, Номер 5(4), С. 48 - 48
Опубликована: Март 31, 2025
The COVID-19 pandemic has led to persistent complications beyond the respiratory system, with emerging evidence highlighting role of gut dysbiosis in long COVID. Given established gut–skin axis, alterations microbiota post-COVID-19 may contribute dermatologic conditions such as eczema, acne, and rosacea. This review explores mechanisms by which SARS-CoV-2 disrupts microbiome, leading systemic inflammation skin disease. Furthermore, it examines potential interventions, including probiotics, prebiotics, dietary modifications, microbiome-targeted therapeutic strategies for post-COVID recovery. Understanding this link open new avenues treating chronic inflammatory COVID patients.
Язык: Английский
Процитировано
0
Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 15
Опубликована: Апрель 22, 2025
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent disease 2019 (COVID-19), in late initiated a global health crisis marked by widespread infection, significant mortality, and long-term implications. While SARS-CoV-2 primarily targets system, recent findings indicate that it also significantly disrupts human microbiome, particularly gut microbiota, contributing to severity, systemic inflammation, immune dysregulation, increased susceptibility secondary infections chronic conditions. Dysbiosis, or microbial imbalance, exacerbates clinical outcomes COVID-19 has been linked long-COVID, condition affecting proportion survivors manifesting with over 200 symptoms across multiple organ systems. Despite growing recognition microbiome alterations COVID-19, precise mechanisms which interacts influences progression remain poorly understood. This narrative review investigates impact on host-microbiota dynamics evaluates its implications severity for developing personalized therapeutic strategies COVID-19. Furthermore, highlights dual role modulating progression, as promising target advancing diagnostic, prognostic, approaches managing
Язык: Английский
Процитировано
0
Exploration of Medicine, Год журнала: 2025, Номер 6
Опубликована: Апрель 28, 2025
The interaction between cancer and coronavirus disease 2019 (COVID-19) poses significant challenges, particularly for immunocompromised individuals who are at heightened risk acute infections long-term complications. pandemic has exacerbated existing vulnerabilities in care by disrupting treatment protocols delaying diagnoses, leading to worsened health outcomes. This article emphasizes the importance of investigating potential impact severe respiratory syndrome 2 (SARS-CoV-2) on progression highlights need effective strategies protect this high-risk population. Long-term consequences, including emergence long COVID, further emphasize ongoing surveillance comprehensive healthcare planning patients during after pandemics. A multifaceted approach is essential, incorporating vaccination, timely therapeutic interventions, sustained support with lingering symptoms. also discusses urges continued research into oncogenic risks associated SARS-CoV-2, which crucial enhancing our understanding broader implications COVID-19 informing public aimed safeguarding future Moreover, data collection development refined clinical guidelines vital improving patient outcomes preparing systems crises. Additionally, mechanisms SARS-CoV-2 may increase susceptibility, chronic inflammation, cellular senescence, immune dysregulation. Understanding these elucidating virus’s potential, among survivors infections. Ensuring continuity resilience global crises requires mitigate disruptions, enhance access screenings treatments, address specific challenges faced experiencing COVID.
Язык: Английский
Процитировано
0
Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 15
Опубликована: Май 29, 2025
Post-COVID-19 syndrome (PCS) is characterized by persistent symptoms and reduced mental physical performance following the acute phase of COVID-19. The underlying mechanisms remain unclear but may involve gut microbiota dysbiosis immune-related changes in amino acid metabolism. This pilot study aimed to investigate whether specific bacterial uremic metabolites (BUM) are altered patients with post-infectious syndromes these alterations associated PCS symptoms. We examined BUM 25 patients, 8 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) healthy controls (Ctrls). Concentrations were determined second morning urine samples using mass spectrometry (Biovis Diagnostik, Limburg, Germany). Standardized questionnaires assesed physical, cognitive, psychological, somatic health status. ME/CFS exhibited significantly higher scores for post-exertional malaise (PEM) symptom severity compared (p<0.001). Elevated concentrations found 64% 37.5% both patients. While overall levels did not differ between groups, heatmap clustering revealed distinct metabolic patterns. tryptamine 4-hydroxyphenylpropionic (HPHPA) hippuric trimethylamine concentrations, exclusively analysed syndromes. Our suggests that metabolomic analysis be a useful approach investigating role PCS.
Язык: Английский
Процитировано
0
Life Sciences, Год журнала: 2024, Номер unknown, С. 123182 - 123182
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
1
Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Дек. 10, 2024
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly impacted global health, affecting not only immediate morbidity and mortality rates but also long-term health outcomes across various populations. Although acute effects of on respiratory system have initially been primary focus, it is increasingly evident that virus can significant impacts multiple physiological systems, including nervous immune systems. pandemic highlighted complex interplay between viral infection, aging, brain potentially accelerate neuroimmune aging contribute to persistence long COVID conditions. By inducing chronic inflammation, immunosenescence, neuroinflammation, may exacerbate processes leading increased risks cognitive decline, neurodegenerative diseases, impaired function. Key factors include dysregulation, oxidative stress, disruption cellular processes. These overlapping mechanisms illustrate how induce aging-related processes, an risk diseases other age-related This mini-review examines key features possible COVID-19-induced severity COVID. Understanding these interactions crucial for developing effective interventions. Anti-inflammatory therapies, neuroprotective agents, immunomodulatory treatments, lifestyle interventions all hold potential mitigating virus. addressing challenges, we improve quality life millions affected pandemic.
Язык: Английский
Процитировано
1
International journal of osteopathic medicine, Год журнала: 2024, Номер unknown, С. 100737 - 100737
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
0