Investigating the biological significance of the TCM principle “promoting urination to regulate bowel movements” through the influence of the intestinal microbiota and their metabolites on the renal-intestinal axis
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
14
Опубликована: Янв. 10, 2025
Treatment
methods
in
traditional
Chinese
medicine
(TCM)
are
foundational
to
their
theoretical,
methodological,
formulaic,
and
pharmacological
systems,
significantly
contributing
syndrome
differentiation
therapy.
The
principle
of
"promoting
urination
regulate
bowel
movements"
is
a
common
therapeutic
approach
TCM.
core
concept
the
dispersion
drainage
water
dampness,
regulating
relieve
diarrhea,"
yet
its
scientific
underpinning
remains
unclear.
Modern
medical
treatment
for
watery
diarrhea
primarily
focuses
on
electrolyte
replenishment,
as
diuretics
may
lead
dehydration
other
side
effects.
Some
reports
suggest
that
this
TCM
lacks
validity.
Microecology,
an
area
associated
with
origins
TCM,
closely
related
development,
diagnosis,
diarrhea.
renal-intestinal
axis
offers
molecular
biological
basis
examining
pathological
mechanisms,
advancing
targets
such
"treating
intestine
address
kidney
issues"
highlighting
interactions
within
"renal-intestinal
microbiota-liquid
metabolism"
framework,
thus
providing
endogenous
mechanism
support
through
kidney."
An
increasing
number
studies
have
shown
intestinal
microbiota
metabolites,
unique
mediators,
involved
physiological
changes
body.
Therefore,
study
explores
relationship
between
fluid
metabolism
from
perspective
aiming
elucidate
mechanisms
underlying
clarify
treating
via
axis.
This
research
provides
new
insights
microbiology.
Язык: Английский
Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DN
Journal of Diabetes,
Год журнала:
2025,
Номер
17(4)
Опубликована: Апрель 1, 2025
ABSTRACT
Background
Diabetic
nephropathy
(DN)
is
a
severe
microvascular
complication
of
diabetes
with
complex
pathogenesis.
Methods
Recent
studies
were
reviewed
to
explore
the
role
gut
microbiota
and
its
metabolites
in
DN
development.
Results
Dysbiosis
bacteria
contributes
pathological
changes
such
as
glomerular
sclerosis
renal
tubule
injury.
Microbial
are
involved
through
immune
inflammatory
pathways.
Conclusions
Understanding
relationship
between
microbiota,
metabolites,
may
offer
potential
implications
for
diagnosis,
prevention,
treatment.
Translating
this
knowledge
into
clinical
practice
presents
challenges
opportunities.
Язык: Английский