Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Дек. 19, 2024
This study aims to investigate the progressive impact of chronic iron overload on olfactory bulb, a region significantly affected in early neurodegenerative diseases like Parkinson's and Alzheimer's. The focus is understanding how accumulation leads oxidative stress, mitochondrial dysfunction, neuronal damage over time middle-aged mice.
Язык: Английский
Brain Sciences, Год журнала: 2025, Номер 15(1), С. 57 - 57
Опубликована: Янв. 10, 2025
Background/Objectives: The study examined the relationships between specific Theory-of-Mind (ToM) dimensions, cognitive planning, and sleep duration in aging adults. Methods: sample included 179 participants, comprising 46 cognitively healthy individuals, 75 diagnosed with amnestic Mild Cognitive Impairment (aMCI), 58 non-amnestic (naMCI). mean age of participants was 70.23 years (SD = 4.74), a educational attainment 12.35 3.22) gender distribution 53 men 126 women. ToM assessment tasks measuring understanding interpretation non-literal speech, proverbs metaphors, as well an emotion-recognition test. For Tower Test utilized. Sleep measured using actigraphy. Results: We identified significant differences various tasks' performance groups, particularly speech third-order stories. HC group consistently outperformed both MCI groups these tasks, aMCI showing higher than naMCI. Mediation analysis applied to examine potential direct indirect effects on indicated that total time had through planning-mainly rule violation score-on aspects. Hence, besides pathologies especially naMCI, seems also be associated via executive functioning decrements. Conclusions: findings underscore social implications deficits due and/or decrease, naMCI older adults, they can seriously impair their interactions. Targeted interventions could improve emotional understanding, communication, overall quality life.
Язык: Английский
Процитировано
1
Phytomedicine, Год журнала: 2025, Номер 142, С. 156729 - 156729
Опубликована: Апрель 12, 2025
Anacyclus pyrethrum (l.) DC has potential value in treating Parkinson's disease (PD)-mild cognitive impairment (MCI), manifesting as impaired memory, attention, executive function, and language. However, the specific targets modes of action A. remain unclear. The aim this study was to identify active components examine their effectiveness a mouse model PD-MCI. We generated ethanol extracts root (EEAP) identified its related using UHPLC-MS/MS network pharmacology.The PD-MCI induced via intraperitoneal administration 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP). After following continuous EEAP,Altered learning or well anxiety, were tested morris water maze, eight-arm radial arm maze (RAM), open-field test,elevated plus-maze. Brain histopathology ultrastructural changes examined brightfield microscopy, electron respectively. Furthermore, protein expression assessed western blotting.Stool samples used for metabolomics analysis by 16S rDNA sequencing determine compositional gut microbiota.We conducted short-chain fatty acid targeted experiment role gut-brain axis Using UPLC-MS-MS, 126 compounds from samples.After searching databases literature reports, 31 544 drug-disease screened. Biological processes molecular functions, such energy channels, cell signaling, metabolism, discovered through GO analysis. showed that average swimming distance escape latency mice EEAP groups decreased. had much higher number errors working memory than control mice. In open field experiment, compared with group, group exhibited an increase movement speed total distance, along decrease residence time.In elevated plus less anxiety Model. Donepezil/Levodopa(D/l) mitigated anxiety-like behavior, (100-400 mg/kg) dose-dependent open-arm metrics, suggesting it may ease mice.Hippocampal tissue treated different doses intact cellular layers hematoxylin-eosin-stained cones slightly better;cells arranged neatly; morphology normal, distributed uniformly. Electron microscopy revealed nuclear membrane, chromatin, nucleoli clearly demarcated hippocampus EEAP, contrary group. brain lighter thinner bands amyloid precursor (APP) Aβ observed those mice, APP blank shown stronger bands. EEAP-treated weaker, indicating reduced expression. lower Bcl-2 Bax levels. treatment increased decreased expression.Compared substantially low glutathione peroxidase (GSH-Px),superoxide dismutase(SOD),catalase (CAT)activity (p < 0.05),much 0.05) EEAP-H model. intervention significantly modulated fecal metabolic profile abundance steroid lipid metabolites, including linoleylethanolamine, markedly altered reversing several these abnormalities. PLS-DA OPLS-DA significant separation between (Q2= 0.542, p 0.01), confirming effect. Random forest 15 key markers, d-glutamine hydrocodone. Metabolic pathway demonstrated enrichment phenylalanine, tyrosine, tryptophan arginine biosynthesis pathways 0.05). Support Vector Machine (SVM) achieved AUC approaching 1, substantial differences metabolite profiles. influenced composition functional intestinal microbiota. Venn diagram illustrates each shared 342 operational taxonomic units (OTUs), 400 exhibiting distinct Bacteroidetes proportion. LEfSe g_Prevotella characteristic bacterium c_Epsilonproteobacteria g_Adlercreutzia 100 Faith's Phylogenetic Diversity (PD) index highest Non-metric Multidimensional Scaling (NMDS)/Principal Coordinates Analysis (PCoA) microbial community structure. Short-chain acids (SCFAs) indicated acetic predominant metabolite, while dose-dependently regulated propionic isovaleric levels (VIP > 0.001). These findings demonstrate exerts regulatory effects reshaping structure functions holds great promise therapeutic agent PD-MCI, exerting multiple mechanisms, regulating expression, modulating profile, microbiota metabolites.
Язык: Английский
Процитировано
0
NeuroImage Clinical, Год журнала: 2025, Номер unknown, С. 103779 - 103779
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Journal of the Neurological Sciences, Год журнала: 2025, Номер unknown, С. 123507 - 123507
Опубликована: Апрель 1, 2025
Neurocognitive disturbances in Parkinson's disease (PD) are common and can impact several aspects of daily functioning quality life. This multicenter study evaluated the efficacy a novel immersive virtual reality (iVR) cognitive training (CT) targeting executive functions (EF)-planning, shifting, updating abilities-to improve prospective memory (PM) PD patients with mild impairment (PD-MCI). Potential transfer effects were also examined healthy older adults (HC). In this double-blind randomized controlled trial, 30 PD-MCI into 4-week EF-training (PD-CT) or active placebo (PD-AP), delivered at home through combined approach telemedicine iVR. Similarly, age- education-matched HC assigned to (HC-CT) (HC-AP). The PD-CT group exhibited significant improvements PM (in time-based verbal-response tasks) EF, particularly inhibition abilities Stroop test), sustained 2-month follow-up. These gains absent PD-AP group. Regression analyses revealed that enhancements primarily driven by improved shifting abilities. was effective adults, HC-CT showed planning Zoo Map test) post-intervention follow-up, while no observed HC-AP innovative iVR-based effectively enhances PD-MCI, demonstrating its potential for improving cognition both populations. findings support use iVR accessible, personalized non-pharmacological interventions.
Язык: Английский
Процитировано
0
The Clinical Neuropsychologist, Год журнала: 2025, Номер unknown, С. 1 - 36
Опубликована: Май 16, 2025
To assess the reliability and diagnostic validity of in-home tele-neuropsychological testing (in-home tele-npt) in individuals with Parkinson's disease (PD). We randomized 79 PD to in-person npt or tele-npt at Baseline, again same crossover group for Week 4 testing. assessed differences mean test scores using ANOVAs Dunnett's t-tests. Test-retest was intraclass correlation coefficients Pearson correlations compared across groups 95% confidence intervals z-tests Fisher's z transformations. percentage participants exceeding each test's standardized regression-based index groups. examined by comparing cognitive classifications Pearson's Chi-square Exact test. For most tests, between were not significantly different. In-home had weaker Baseline processing speed scores. The test-retest similar repeated tests. speed, verbal fluency, memory significant change varied classified as cognitively impaired, agreement classification sessions, different With few exceptions, yield is better when paradigm held constant. There are no rates paradigms PD.
Язык: Английский
Процитировано
0
Alzheimer s & Dementia, Год журнала: 2025, Номер 21(5)
Опубликована: Май 1, 2025
Abstract INTRODUCTION The α‐synuclein (αSyn) seed amplification assay (αSyn‐SAA) is an accurate tool to detect αSyn seeds in patients with Parkinson's disease (PD). However, a minority of clinically diagnosed PD are negative for αSyn. METHODS αSyn‐SAA was performed cerebrospinal fluid (CSF) individuals ( n = 93), multiple system atrophy (MSA, 26), progressive supranuclear palsy (PSP, 18), corticobasal syndrome 3), and healthy controls 29). RESULTS detected 90% 81% MSA patients, while exhibiting high specificity (97%). SAA– had distinct phenotype compared SAA+ PD, including marked postural instability/gait disorder P 0.002), impaired episodic memory, lower CSF amyloid beta 42 0.03). PSP also displayed distinctive traits. DISCUSSION A associated pathological findings suggesting that these may have motor subtype Alzheimer's disease. This could influence future clinical trials. Highlights robust assay. αSyn‐SAA–negative shows motor–cognitive phenotype. Autopsy showed (AD) pathology parkinsonian diseases. AD stands as major confounder the diagnosis movement disorders.
Язык: Английский
Процитировано
0
Journal of Neural Transmission, Год журнала: 2024, Номер 132(2), С. 169 - 201
Опубликована: Окт. 25, 2024
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12176 - 12176
Опубликована: Ноя. 13, 2024
α-synuclein oligomers within synaptic terminals of autonomic fibers the skin reliably discriminate Parkinson’s disease (PD) patients from healthy controls. Nonetheless, prognostic role for progression is unknown. We explored whether evaluated as proximity ligation assay (PLA) score may predict worsening cognitive functions in with disease. Thirty-four PD and thirty-four controls (HC), matched 1:1 age sex, were enrolled. Patients underwent baseline biopsy an assessment domains including Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Clock Drawing Test, Frontal Battery. At last follow-up visit available, either cognitively stable (PD-CS) or deteriorated (PD-CD). quantified PLA scores. Differences between groups assessed, controlling potential confounders. The relationship measures changes was using correlation multivariable regression analyses. discrimination power assessed via ROC curve. To elucidate longitudinal measures, we conducted analyses delta scores tests (Δ) dependent variables. found that PD-CD had higher than PD-CS (p = 0.0003), they correctly identified curve analysis (AUC 0.872, p 0.0003). Furthermore, ANCOVA Bonferroni correction, considering all (PD-CS, PD-CD, HC), showed significant differences 0.003), HC 0.002), < 0.001). In model ΔMMSE variable, to be a predictor (β −0.441, 0.016). Similar results observed when evaluating ΔMoCA −0.378, 0.042). conclusion, burden peripheral nervous system more susceptible decline.
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Дек. 19, 2024
This study aims to investigate the progressive impact of chronic iron overload on olfactory bulb, a region significantly affected in early neurodegenerative diseases like Parkinson's and Alzheimer's. The focus is understanding how accumulation leads oxidative stress, mitochondrial dysfunction, neuronal damage over time middle-aged mice.
Язык: Английский
Процитировано
0