Frontiers in Cardiovascular Medicine,
Год журнала:
2021,
Номер
8
Опубликована: Ноя. 12, 2021
Inflammation
and
nutrition
as
main
factors
can
affect
the
prognosis
of
patients
with
chronic
total
coronary
occlusion
(CTO)
undergoing
percutaneous
intervention
(PCI).
The
C-reactive
protein
to
albumin
ratio
(CAR)
clarify
inflammation
status,
which
are
highly
related
clinical
outcomes.
This
study
aims
investigate
association
between
CAR
adverse
cardiovascular
events
in
CTO
PCI.
For
this
study,
664
were
divided
into
three
groups
based
on
tertiles
CAR.
primary
endpoint
was
all-cause
mortality
secondary
major
(MACE).
Over
a
median
follow-up
33.7
months,
occurred
64
(9.6%)
170
(25.6%).
higher
represented
worse
death
after
adjustment
for
baseline
risk
factors.
Adding
values
raised
predictive
value
incidence
but
not
MACE.
capacity
prediction
improved
addition
traditional
model.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
171, С. 116136 - 116136
Опубликована: Янв. 11, 2024
Heart
Failure
(HF)
epitomizes
a
formidable
global
health
quandary
characterized
by
marked
morbidity
and
mortality.
It
has
been
established
that
severe
derangements
in
energy
metabolism
are
central
to
the
pathogenesis
of
HF,
culminating
an
inadequate
cardiac
milieu,
which,
turn,
precipitates
pump
dysfunction
systemic
metabolic
failure,
thereby
steering
trajectory
potential
recuperation
HF.
The
conventional
therapeutic
paradigms
for
HF
predominantly
target
amelioration
heart
rate,
preload
afterload,
proffering
symptomatic
palliation
or
decelerating
disease
progression.
However,
realm
therapeutics
targeting
remains
largely
uncharted.
This
review
delineates
quintessential
characteristics
healthy
hearts,
aberrations
observed
during
alongside
associated
pathways
targets.
Furthermore,
we
delve
into
phytochemicals
rectifying
redox
disequilibrium
perturbations
Through
exhaustive
analysis
recent
advancements,
underscore
promise
modulating
these
pathways,
unfurling
novel
vista
on
therapeutics.
Given
their
orchestrating
metabolism,
emerging
as
burgeoning
frontier
treatment.
accentuates
imperative
deeper
exploration
how
specifically
intervene
subsequent
translation
findings
clinical
applications,
broadening
horizon
treatment
modalities.
Abstract
Previous
studies
have
found
that
miR-335
is
highly
expressed
in
type
II
diabetes
mellitus
(T2DM)
models
and
related
to
insulin
secretion,
but
there
are
few
on
the
regulatory
effects
of
miR-335-3p
resistance
macrophage
polarization
T2DM
patients.
This
study
aims
explore
Blood
glucose
(insulin
tolerance
tests,
tests)
body
weight
model
were
measured;
macrophages
from
adipose
tissue
isolated
cultured,
number
was
detected
by
F4/80
immunofluorescence
assay;
Real-time
quantitative
polymerase
chain
reaction
(qPCR)
assay
Western
blot
used
detect
expression
levels,
insulin-like
growth
factor
1
(IGF-1),
M1-polarizing
genes
(inducible
nitric
oxide
synthase
[iNOS]
TNF-α)
as
well
M2-polarizing
(IL-10
ARG-1).
The
targeting
link
between
IGF-1
confirmed
using
bioinformatics
dual
luciferase
assay.
results
showed
level
significantly
decreased,
mice’s
blood
levels
dropped
considerably,
inhibited
macrophages,
inhibiting
iNOS
TNF-α
relative
mRNA
up-regulated
IL-10
ARG-1
negatively
regulated
target
gene
IGF-1,
increased
protein
decreasing
indicating
could
affect
process
regulating
via
IGF-1.
Medicina,
Год журнала:
2024,
Номер
60(8), С. 1315 - 1315
Опубликована: Авг. 14, 2024
Background
and
Objectives:
Chronic
heart
failure
(CHF)
caused
by
ischemic
disease
(IHD)
is
the
leading
cause
of
death
worldwide
presents
significant
health
challenges.
Effective
management
IHD
requires
prevention,
early
detection,
treatment
to
improve
patient
outcomes.
This
study
aims
expand
diagnostic
utility
various
24
h
Holter
ECG
parameters,
such
as
T-wave
alternans
(TWA),
late
ventricular
potentials
(LVPs),
rate
variability
(HRV)
in
patients
with
CHF
IHD.
Additionally,
we
seek
explore
association
between
these
parameters
other
comorbid
conditions
affecting
prognosis
patients.
Materials
Methods:
We
conducted
a
prospective
case–control
150
divided
into
two
subgroups:
100
IHD,
50
control
group.
Data
included
medical
history,
physical
examination,
laboratory
tests,
echocardiography,
monitoring.
Results:
Our
comparative
analysis
demonstrated
that
both
TWA
LVPs
were
significantly
higher
compared
group
(p
<
0.01),
indicating
increased
myocardial
electrical
vulnerability
Both
time
frequency-domain
HRV
lower
However,
ratio
NN50
total
count
NN
intervals
(PNN50)
showed
borderline
significance
=
0.06).
While
low-frequency
(LF)
domain
was
patients,
high-frequency
(HF)
did
not
differ
groups.
Acceleration
deceleration
capacities
also
altered
Categorizing
left
ejection
fraction
(LVEF)
revealed
mean
5-min
normal-to-normal
over
complete
recording
(SDNN
Index)
LVEF
≥
50%
those
reduced
EF
mildly
0.001),
whereas
no
differences
among
Conclusions:
can
become
reliable
tool
assessment
CHF.
The
integration
multiple
TWA,
LVPs,
HRV,
enhance
comprehensive
approach
allows
for
more
nuanced
understanding
patient’s
condition
potential
Frontiers in Cardiovascular Medicine,
Год журнала:
2021,
Номер
8
Опубликована: Ноя. 12, 2021
Inflammation
and
nutrition
as
main
factors
can
affect
the
prognosis
of
patients
with
chronic
total
coronary
occlusion
(CTO)
undergoing
percutaneous
intervention
(PCI).
The
C-reactive
protein
to
albumin
ratio
(CAR)
clarify
inflammation
status,
which
are
highly
related
clinical
outcomes.
This
study
aims
investigate
association
between
CAR
adverse
cardiovascular
events
in
CTO
PCI.
For
this
study,
664
were
divided
into
three
groups
based
on
tertiles
CAR.
primary
endpoint
was
all-cause
mortality
secondary
major
(MACE).
Over
a
median
follow-up
33.7
months,
occurred
64
(9.6%)
170
(25.6%).
higher
represented
worse
death
after
adjustment
for
baseline
risk
factors.
Adding
values
raised
predictive
value
incidence
but
not
MACE.
capacity
prediction
improved
addition
traditional
model.
