The Usefulness of C-Reactive Protein to Albumin Ratio in the Prediction of Adverse Cardiovascular Events in Coronary Chronic Total Occlusion Undergoing Percutaneous Coronary Intervention DOI Creative Commons
Lele Cheng, Zixuan Meng, Qi Wang

и другие.

Frontiers in Cardiovascular Medicine, Год журнала: 2021, Номер 8

Опубликована: Ноя. 12, 2021

Inflammation and nutrition as main factors can affect the prognosis of patients with chronic total coronary occlusion (CTO) undergoing percutaneous intervention (PCI). The C-reactive protein to albumin ratio (CAR) clarify inflammation status, which are highly related clinical outcomes. This study aims investigate association between CAR adverse cardiovascular events in CTO PCI. For this study, 664 were divided into three groups based on tertiles CAR. primary endpoint was all-cause mortality secondary major (MACE). Over a median follow-up 33.7 months, occurred 64 (9.6%) 170 (25.6%). higher represented worse death after adjustment for baseline risk factors. Adding values raised predictive value incidence but not MACE. capacity prediction improved addition traditional model.

Язык: Английский

Pathological mechanisms of cigarette smoking, dietary, and sedentary lifestyle risks in vascular dysfunction: mitochondria as a common target of risk factors DOI
Sergey Dikalov, Sergey Gutor, Anna Dikalova

и другие.

Pflügers Archiv - European Journal of Physiology, Год журнала: 2023, Номер 475(7), С. 857 - 866

Опубликована: Март 30, 2023

Язык: Английский

Процитировано

7

Energy metabolism and redox balance: How phytochemicals influence heart failure treatment DOI Creative Commons
Cong Chen, Jie Wang, Xueying Zhu

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 171, С. 116136 - 116136

Опубликована: Янв. 11, 2024

Heart Failure (HF) epitomizes a formidable global health quandary characterized by marked morbidity and mortality. It has been established that severe derangements in energy metabolism are central to the pathogenesis of HF, culminating an inadequate cardiac milieu, which, turn, precipitates pump dysfunction systemic metabolic failure, thereby steering trajectory potential recuperation HF. The conventional therapeutic paradigms for HF predominantly target amelioration heart rate, preload afterload, proffering symptomatic palliation or decelerating disease progression. However, realm therapeutics targeting remains largely uncharted. This review delineates quintessential characteristics healthy hearts, aberrations observed during alongside associated pathways targets. Furthermore, we delve into phytochemicals rectifying redox disequilibrium perturbations Through exhaustive analysis recent advancements, underscore promise modulating these pathways, unfurling novel vista on therapeutics. Given their orchestrating metabolism, emerging as burgeoning frontier treatment. accentuates imperative deeper exploration how specifically intervene subsequent translation findings clinical applications, broadening horizon treatment modalities.

Язык: Английский

Процитировано

2

miR-335-3p improves type II diabetes mellitus by IGF-1 regulating macrophage polarization DOI Creative Commons

Zhengzheng Ju,

Fan Cui,

Zheng Mao

и другие.

Open Medicine, Год журнала: 2024, Номер 19(1)

Опубликована: Янв. 1, 2024

Abstract Previous studies have found that miR-335 is highly expressed in type II diabetes mellitus (T2DM) models and related to insulin secretion, but there are few on the regulatory effects of miR-335-3p resistance macrophage polarization T2DM patients. This study aims explore Blood glucose (insulin tolerance tests, tests) body weight model were measured; macrophages from adipose tissue isolated cultured, number was detected by F4/80 immunofluorescence assay; Real-time quantitative polymerase chain reaction (qPCR) assay Western blot used detect expression levels, insulin-like growth factor 1 (IGF-1), M1-polarizing genes (inducible nitric oxide synthase [iNOS] TNF-α) as well M2-polarizing (IL-10 ARG-1). The targeting link between IGF-1 confirmed using bioinformatics dual luciferase assay. results showed level significantly decreased, mice’s blood levels dropped considerably, inhibited macrophages, inhibiting iNOS TNF-α relative mRNA up-regulated IL-10 ARG-1 negatively regulated target gene IGF-1, increased protein decreasing indicating could affect process regulating via IGF-1.

Язык: Английский

Процитировано

2

Enhancing Comprehensive Assessments in Chronic Heart Failure Caused by Ischemic Heart Disease: The Diagnostic Utility of Holter ECG Parameters DOI Creative Commons
Ștefania-Teodora Duca, Ionuț Tudorancea, Mihai Ștefan Cristian Haba

и другие.

Medicina, Год журнала: 2024, Номер 60(8), С. 1315 - 1315

Опубликована: Авг. 14, 2024

Background and Objectives: Chronic heart failure (CHF) caused by ischemic disease (IHD) is the leading cause of death worldwide presents significant health challenges. Effective management IHD requires prevention, early detection, treatment to improve patient outcomes. This study aims expand diagnostic utility various 24 h Holter ECG parameters, such as T-wave alternans (TWA), late ventricular potentials (LVPs), rate variability (HRV) in patients with CHF IHD. Additionally, we seek explore association between these parameters other comorbid conditions affecting prognosis patients. Materials Methods: We conducted a prospective case–control 150 divided into two subgroups: 100 IHD, 50 control group. Data included medical history, physical examination, laboratory tests, echocardiography, monitoring. Results: Our comparative analysis demonstrated that both TWA LVPs were significantly higher compared group (p < 0.01), indicating increased myocardial electrical vulnerability Both time frequency-domain HRV lower However, ratio NN50 total count NN intervals (PNN50) showed borderline significance = 0.06). While low-frequency (LF) domain was patients, high-frequency (HF) did not differ groups. Acceleration deceleration capacities also altered Categorizing left ejection fraction (LVEF) revealed mean 5-min normal-to-normal over complete recording (SDNN Index) LVEF ≥ 50% those reduced EF mildly 0.001), whereas no differences among Conclusions: can become reliable tool assessment CHF. The integration multiple TWA, LVPs, HRV, enhance comprehensive approach allows for more nuanced understanding patient’s condition potential

Язык: Английский

Процитировано

2

The Usefulness of C-Reactive Protein to Albumin Ratio in the Prediction of Adverse Cardiovascular Events in Coronary Chronic Total Occlusion Undergoing Percutaneous Coronary Intervention DOI Creative Commons
Lele Cheng, Zixuan Meng, Qi Wang

и другие.

Frontiers in Cardiovascular Medicine, Год журнала: 2021, Номер 8

Опубликована: Ноя. 12, 2021

Inflammation and nutrition as main factors can affect the prognosis of patients with chronic total coronary occlusion (CTO) undergoing percutaneous intervention (PCI). The C-reactive protein to albumin ratio (CAR) clarify inflammation status, which are highly related clinical outcomes. This study aims investigate association between CAR adverse cardiovascular events in CTO PCI. For this study, 664 were divided into three groups based on tertiles CAR. primary endpoint was all-cause mortality secondary major (MACE). Over a median follow-up 33.7 months, occurred 64 (9.6%) 170 (25.6%). higher represented worse death after adjustment for baseline risk factors. Adding values raised predictive value incidence but not MACE. capacity prediction improved addition traditional model.

Язык: Английский

Процитировано

14