Association Between Low Triglyceride-Glucose Index and Mortality in Acute Decompensated Heart Failure Patients Without Diabetes

Journal of Multidisciplinary Healthcare, Год журнала: 2025, Номер Volume 18, С. 1711 - 1719

Опубликована: Март 1, 2025

The relationship between a low TyG index and mortality risk in Acute Decompensated Heart Failure (ADHF) also remains unclear. This study aimed to investigate the association 1-year ADHF patients without diabetes. A total of 652 hospitalized with diabetes from January, 2020 May, 2023 were included this retrospective study. primary outcomes all-cause cardiovascular within one year. both was investigated using restricted cubic splines multivariate Cox proportional hazards models. enrolled acute decompensated heart failure who free (70.6% male). Within year, there 72 deaths all causes 40 disease. In models, significant negative observed (hazard ratio [HR] = 0.371, 95% confidence interval [CI] 0.201-0.685) (HR 0.336, CI 0.151-0.744). spline analysis illustrated decrease as increased. Hypertension, BMI, age, atrial fibrillation significantly interacted relation mortality, while hypertension specifically regarding mortality. diagnosed diabetes, lower is strongly related higher Therefore, it important pay close attention levels implement appropriate measures clinical practice.

Язык: Английский

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Molecular Insights into Oxidative-Stress-Mediated Cardiomyopathy and Potential Therapeutic Strategies

Biomolecules, Год журнала: 2025, Номер 15(5), С. 670 - 670

Опубликована: Май 6, 2025

Cardiomyopathies comprise a heterogeneous group of cardiac disorders characterized by structural and functional abnormalities in the absence significant coronary artery disease, hypertension, valvular or congenital defects. Major subtypes include hypertrophic, dilated, arrhythmogenic, stress-induced cardiomyopathies. Oxidative stress (OS), resulting from an imbalance between reactive oxygen species (ROS) production antioxidant defenses, has emerged as key contributor to pathogenesis these conditions. ROS-mediated injury drives inflammation, protease activation, mitochondrial dysfunction, cardiomyocyte damage, thereby promoting remodeling decline. Although numerous studies implicate OS cardiomyopathy progression, precise molecular mechanisms remain incompletely defined. This review provides updated synthesis current findings on OS-related signaling pathways across subtypes, emphasizing emerging therapeutic targets within redox-regulatory networks. A deeper understanding may guide development targeted strategies improve clinical outcomes affected patients.

Язык: Английский

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CTRP3 attenuates myocardial lipotoxicity via suppression of lipid accumulation, inflammation, apoptosis, and mitochondrial oxidative stress

Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 12

Опубликована: Май 13, 2025

Myocardial lipotoxicity, a pathophysiological condition characterized by cardiomyocyte damage resulting from dysregulated fatty acid metabolism, plays pivotal role in cardiovascular disease progression. C1q/tumor necrosis factor-related protein-3 (CTRP3), novel adipocytokine with pleiotropic metabolic regulatory properties, has recently been implicated lipid homeostasis modulation. Nevertheless, its cardioprotective potential against myocardial lipotoxicity remains poorly understood. A comprehensive approach combining vivo high-fat diet (HFD) murine models and vitro palmitic acid-induced injury systems was employed. this study used animal cellular experiments to verify the function of CTRP3. HFD feeding induced significant droplet deposition cardiomyocytes, concomitant enhanced inflammatory responses, elevated apoptotic activity, exacerbated oxidative stress, ultimately leading cardiac dysfunction. Both cardiac-specific CTRP3 overexpression exogenous recombinant (rCTRP3) administration demonstrated remarkable effects, manifested through: (1) Significant attenuation intramyocardial accumulation (p < 0.05) (2) Suppression pathways (3) Inhibition mitochondrial-dependent apoptosis (4) Enhancement antioxidant defense systems. These coordinated effects substantially ameliorated lipotoxic improved functional parameters. Our findings reveal that confers robust protection through multi-modal mechanisms involving metabolism regulation, anti-inflammatory actions, inhibition, stress mitigation, highlighting therapeutic for cardiomyopathy.

Язык: Английский

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Association between systemic inflammation markers and blood pressure among children and adolescents: National Health and Nutrition Examination Survey

Pediatric Research, Год журнала: 2024, Номер unknown

Опубликована: Авг. 17, 2024

Язык: Английский

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Recent advances on the Role of Gut Microbiota in the Development of Heart Failure by Mediating Immune Metabolism

Current Problems in Cardiology, Год журнала: 2023, Номер 49(3), С. 102128 - 102128

Опубликована: Окт. 5, 2023

Язык: Английский

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