Connecting the Dots: How MicroRNAs Link Asthma and Atherosclerosis

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3570 - 3570

Опубликована: Апрель 10, 2025

Asthma and atherosclerosis are chronic conditions with distinct pathophysiologies, but overlapping inflammatory mechanisms that suggest a potential common regulatory framework. MicroRNAs (miRNAs), small non-coding RNA molecules modulate gene expression post-transcriptionally, could be key players in linking these disorders. This review outlines how miRNAs contribute to the complex interplay between asthma atherosclerosis, focusing on involved pathways, immune cell regulation vascular remodeling. We discuss specific miRNAs, such as miR-155, miR-21 miR-146a, which have been shown cytokine production T differentiation, impacting respiratory cardiovascular health. The found both emphasize their role biomarkers, also therapeutic targets. Understanding molecular connections may unlock novel approaches for innovative, integrated treatment strategies address significantly improve patient outcomes. Further research is needed explore mechanistic pathways validate translational of miRNA-based interventions preclinical clinical settings.

Язык: Английский

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Role of Exosomes in Cardiovascular Disease: A Key Regulator of Intercellular Communication in Cardiomyocytes

ACS Omega, Год журнала: 2025, Номер unknown

Опубликована: Май 5, 2025

In the cardiovascular system, different types of cells can secrete specific exosomes and participate in maintenance function occurrence development diseases. Exosomes carry biologically active substances such as proteins nucleic acids from origin be used biomarkers for disease diagnosis prognosis assessment. addition, exosome-mediated intercellular communication plays a key role diseases has become potential therapeutic target. This article emphasizes importance understanding mechanism systematically details current regulators cardiomyocytes, providing basis future research intervention.

Язык: Английский

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Therapeutic Applications of Poly-miRNAs and miRNA Sponges

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(10), С. 4535 - 4535

Опубликована: Май 9, 2025

MicroRNAs (miRNAs) are small, non-coding RNA molecules that play crucial roles in regulating gene expression, and their dysregulation is implicated various human diseases. Over the years, several research groups have identified miRNAs as promising therapeutic targets for intervention. Therapeutic strategies involve either overexpression or knockdown of specific miRNAs. This review aims to provide a comprehensive overview synthetic poly-miRNAs miRNA sponges, highlighting applications. It begins with an introduction role diseases, followed by detailed discussion on sponges exploring application cardiovascular, inflammatory, autoimmune, metabolic disorders, well cancer therapy. Additionally, targeted delivery, challenges, limitations these therapies addressed.

Язык: Английский

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MiR-34a rs2666433 and cognitive function in major depressive disorder: a clinical correlation analysis

Nucleosides Nucleotides & Nucleic Acids, Год журнала: 2025, Номер unknown, С. 1 - 14

Опубликована: Июнь 2, 2025

Genetic factors play a crucial role in the development of major depressive disorder (MDD). This study aimed to investigate association between microRNA (miR)-34a rs266643 polymorphism and MDD, as well its impact on cognitive function. Clinical data blood samples were collected from 302 MDD patients 306 healthy controls who met predefined inclusion exclusion criteria. The severity was assessed using Hamilton Rating Scale for Depression (HRSD). Cognitive function evaluated Mini-Mental State Examination (MMSE), Stroop Color-Word Test (Stroop-C Stroop-CW), Montreal Assessment (MoCA). Gene typing performed Sanger sequencing method, while relative expression level miR-34a quantified by RT-qPCR. group exhibited significantly higher fold change compared control (p < 0.001). Among genotypes, AA genotype demonstrated highest expression, followed GA, with both being greater than GG. positively correlated HRSD, Stroop-C, Stroop-CW scores but negatively MMSE MoCA Carrying A allele (OR = 1.468, p 0.002) or 2.382, 0.001) associated an increased risk MDD. Furthermore, poorer other genotypes. gene rs2666433

Язык: Английский

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Genetic deletion of microRNA-34 unmasks cardiac vulnerability to psychosocial stress in male mice

Physiology & Behavior, Год журнала: 2025, Номер unknown, С. 114984 - 114984

Опубликована: Июнь 1, 2025

Язык: Английский

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