Biomedicines,
Год журнала:
2025,
Номер
13(3), С. 720 - 720
Опубликована: Март 15, 2025
Sodium–glucose
cotransporter-2
inhibitors
(SGLT2i)
are
a
specific
class
of
drugs
originally
developed
for
treating
type
2
diabetes
mellitus.
Subsequently,
studies
demonstrated
that
their
action
was
not
limited
to
glycemic
control
but
could
also
have
positive
effects
on
other
outcomes,
particularly
at
the
cardiovascular
level.
Indeed,
due
diuretic
effect,
SGLT2i
improve
clinical
chronic
heart
failure
and
reduce
risk
rehospitalization.
In
addition,
reported
protective
effect
major
events
mortality.
More
recently,
it
has
been
suggested
prescription
after
an
acute
myocardial
infarction
may
possible
inflammation,
arrhythmias,
ventricular
remodeling.
Here,
we
reviewed
focused
in
patients
treated
with
percutaneous
coronary
intervention.
Cardiovascular Diabetology,
Год журнала:
2024,
Номер
23(1)
Опубликована: Дек. 28, 2024
Perivascular
adipose
tissue
(PVAT)
is
a
dynamic
that
affects
vascular
function
and
cardiovascular
health.
The
connection
between
PVAT,
the
immune
system,
obesity,
disease
complex
plays
pivotal
role
in
pathogenesis
of
diseases
such
as
atherosclerosis,
hypertension,
inflammation.
In
cardiometabolic
diseases,
PVAT
becomes
significant
source
proflammatory
adipokines,
leading
to
increased
infiltration
cells,
proinflammatory
promoting
smooth
muscle
cell
proliferation
migrationpromoting
migration.
This
exacerbates
dysfunction
by
impairing
endothelial
activation.
Dysregulated
also
contributes
hemodynamic
alterations
hypertension
through
enhanced
sympathetic
nervous
system
activity
impaired
vasodilatory
capacity
PVAT-derived
factors.
Therapeutic
interventions
targeting
key
components
this
interaction,
modulating
inflammation,
restoring
adipokine
balance,
attenuating
activation,
hold
promise
for
mitigating
obesity-related
complications.
Lifestyle
interventions,
pharmacological
agents
inflammatory
pathways,
surgical
approaches
aimed
at
reducing
mass
or
improving
are
potential
therapeutic
avenues
managing
associated
with
obesity
dysfunction.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 2, 2025
New-onset
atrial
fibrillation
(NOAF)
is
associated
with
increased
morbidity
and
mortality.
Despite
identifying
numerous
factors
contributing
to
NOAF,
the
underlying
mechanisms
remain
uncertain.
This
study
introduces
triglyceride-glucose
index
(TyG
index)
as
a
predictive
indicator
establishes
clinical
model.
We
included
551
patients
acute
myocardial
infarction
(AMI)
without
history
of
(AF).
These
were
divided
into
two
groups
based
on
occurrence
postoperative
NOAF
during
hospitalization:
group
(n
=
94)
sinus
rhythm
(SR)
457).
utilized
regression
model
analyze
risk
establish
The
performance,
calibration,
effectiveness
evaluated
using
receiver
operational
characteristics
(ROC),
calibration
curve,
decision
curve
analysis,
impact
curve.
94
developed
hospitalization.
TyG
was
identified
an
independent
predictor
significantly
higher
in
group.
Left
(LA)
diameter,
age,
systemic
inflammatory
response
(SIRI),
creatinine
also
for
NOAF.
Combining
these
build
prediction
resulted
area
under
(AUC)
0.780
(95%
CI
0.358–0.888).
ROC,
demonstrated
that
performance
new
nomogram
satisfactory.
By
incorporating
model,
after
AMI
hospitalization
can
be
effectively
predicted.
Early
detection
improve
prognosis
patients.
Biomarkers in Medicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 8
Опубликована: Янв. 29, 2025
Newly
diagnosed
AF
(NOAF)
associated
with
acute
STEMI
holds
significant
relevance
in
clinical
practice.
This
study
seeks
to
assess
the
role
of
monocyte
HDL-C
ratio
(MHR)
predicting
NOAF
these
patients.
Between
July
2017
and
May
2018,
663
patients
who
underwent
primary
PCI
for
were
retrospectively
analyzed.
was
identified
34
(5.1%),
this
group
compared
those
without
AF.
The
experienced
a
longer
hospitalization
duration
higher
mortality
rate
(11.8
vs.
4.3%,
p
=
0.044)
non-AF
group.
In
multivariable
analysis,
increased
MHR
(OR:
1.413,
95%
CI:
1.203-1.657,
0.005),
advanced
age,
decreased
LVEF,
Killip
class
2-4,
diabetes
mellitus,
hypertension,
left
atrial
enlargement
emerged
as
independent
predictors
development
STEMI.
ROC
curve
analysis
revealed
that
values
exceeding
26.54
strongly
predict
NOAF,
achieving
sensitivity
specificity
above
70%
(AUC:
0.768,
95%CI:
0.734-0.801,
<
0.001).
present
robust
indicator
can
be
easily
assessed
Incorporating
alongside
established
traditional
risk
factors
may
enhance
identification
at
Biomedicines,
Год журнала:
2025,
Номер
13(3), С. 720 - 720
Опубликована: Март 15, 2025
Sodium–glucose
cotransporter-2
inhibitors
(SGLT2i)
are
a
specific
class
of
drugs
originally
developed
for
treating
type
2
diabetes
mellitus.
Subsequently,
studies
demonstrated
that
their
action
was
not
limited
to
glycemic
control
but
could
also
have
positive
effects
on
other
outcomes,
particularly
at
the
cardiovascular
level.
Indeed,
due
diuretic
effect,
SGLT2i
improve
clinical
chronic
heart
failure
and
reduce
risk
rehospitalization.
In
addition,
reported
protective
effect
major
events
mortality.
More
recently,
it
has
been
suggested
prescription
after
an
acute
myocardial
infarction
may
possible
inflammation,
arrhythmias,
ventricular
remodeling.
Here,
we
reviewed
focused
in
patients
treated
with
percutaneous
coronary
intervention.
