Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Ноя. 24, 2022
Sepsis
is
a
severe
clinical
syndrome
caused
by
dysregulated
systemic
inflammatory
responses
to
infection.
Methylation
modification,
as
crucial
mechanism
of
RNA
functional
can
manipulate
the
immunophenotype
and
activity
immune
cells
participate
in
sepsis
progression.
This
study
aims
explore
N6-methyladenosine
(m6A)
methylation
modification
cell-mediated
through
keyword
search.Literature
retrieval.Literature
retrieval
reveals
that
m6A
implicated
sepsis-induced
lung
injury
myocardial
injury,as
well
sepsis-related
encephalopathy.
Furthermore,
it
found
regulate
inhibiting
chemotaxis
neutrophils
formation
neutrophil
extracellular
traps
suppressing
macrophage
phagocytosis,
thereby
playing
role
sepsis.
Frontiers in RNA Research,
Год журнала:
2025,
Номер
3
Опубликована: Апрель 10, 2025
Among
over
170
known
RNA
modifications,
N
6
-methyladenosine
(m
A)
stands
out
as
the
most
ubiquitous
and
extensively
studied
modification,
found
in
different
cellular
RNA.
The
m
A
plays
a
pivotal
role
regulating
nuclear
export,
stability,
secondary
structure,
translation,
degradation
eventually
determining
gene
expression.
modification
is
controlled
by
three
classes
of
enzymes:
“writers”,
“erasers”,
“readers”
which
not
only
play
adding
removing
methyl
group
but
also
help
recognizing
interpreting
methylation
marks.
Although
has
been
widely
context
metabolic
diseases
cancers,
its
influence
on
infectious
remains
under-explored.
infection
cycle
several
pathogens,
including
viruses,
bacteria,
parasites
regulated
machinery.
In
this
review,
we
will
explore
existing
knowledge
about
shaping
pathogen
life
paving
our
way
to
therapeutic
aspects
mitigate
diseases.
Frontiers in Cellular Neuroscience,
Год журнала:
2022,
Номер
16
Опубликована: Сен. 29, 2022
Central
nervous
system
(CNS)
injuries,
including
traumatic
brain
injury
(TBI),
intracerebral
hemorrhage
(ICH)
and
ischemic
stroke,
are
the
most
common
cause
of
death
disability
around
world.
As
modification
on
ribonucleic
acids
(RNAs),
N6-methyladenosine
(m6A)
has
recently
attracted
great
attentions
due
to
its
functions
in
determining
fate
RNAs
through
changes
splicing,
translation,
degradation
stability.
A
large
number
studies
have
suggested
that
m6A
played
an
important
role
development
involved
many
neurological
disorders,
particularly
CNS
injuries.
It
been
proposed
could
improve
impairment,
inhibit
apoptosis,
suppress
inflammation,
reduce
pyroptosis
attenuate
ferroptosis
injuries
via
different
molecules
phosphatase
tensin
homolog
(PTEN),
NLR
family
pyrin
domain
containing
3
(NLRP3),
B-cell
lymphoma
2
(Bcl-2),
glutathione
peroxidase
4
(GPX4),
long
non-coding
RNA
(lncRNA).
Therefore,
showed
promise
as
potential
targets
In
this
article,
we
present
a
review
highlighting
Hence,
basis
these
properties
effects,
may
be
developed
therapeutic
agents
for
patients.
PeerJ,
Год журнала:
2023,
Номер
11, С. e15269 - e15269
Опубликована: Май 11, 2023
Recent
studies
have
shown
that
the
potential
regulatory
role
of
N6-methyladenine
(m6A)
modification
may
affect
occurrence
and
development
various
cardiovascular
diseases.
However,
mechanism
m6A
on
myocardial
ischemia
reperfusion
injury
(MIRI)
is
rarely
reported.
A
mouse
model
(I/R)
was
established
by
ligation
perfusion
left
anterior
descending
coronary
artery,
a
cellular
hypoxia/reperfusion
(H/R)
conducted
in
cardiomyocytes
(CMs).
We
found
protein
expression
ALKBH5
tissues
cells
were
decreased,
accompanied
increased
level.
Overexpression
significantly
inhibited
H/R-induced
oxidative
stress
apoptosis
CMs.
Mechanistically,
there
an
enriched
motif
3'-UTR
SIRT1
genome,
overexpression
promoted
stability
mRNA.
Furthermore,
results
using
or
knockdown
confirmed
protective
effect
H/R
induced
CMs
apoptosis.
Together,
our
study
reveals
critical
ALKBH5-medicated
CM
apoptosis,
supplying
important
regulating
methylation
ischemic
heart
disease.
Heliyon,
Год журнала:
2023,
Номер
9(6), С. e16905 - e16905
Опубликована: Июнь 1, 2023
Blood-brain
barrier
(BBB)
breakdown
is
a
critical
event
in
cerebral
ischemia-reperfusion
(I/R)
injury,
and
matrix
metalloproteinases
(MMPs),
which
are
proteolytic
enzymes,
play
essential
roles
BBB
through
degrading
the
extracellular
matrix.
N6-Methyladenosine
(m6A),
most
common
reversible
mRNA
modification,
has
an
important
role
progression
of
I/R
injury.
However,
whether
m6A
related
to
MMPs
expression
injury
still
not
clear.
In
this
study,
we
explored
potential
effects
modification
on
its
underlying
mechanisms
using
mice
subjected
transient
middle
artery
occlusion
reperfusion
(MCAO/R),
mouse
brain
endothelial
cells
treated
with
oxygen-glucose
deprivation
reoxygenation
(OGD/R).
We
find
that
MMP3
highly
expressed
positively
associated
writer
CBLL1
(Cbl
proto-oncogene
like
1)
vivo
vitro.
Furthermore,
occurs
cells,
level
significantly
increased
Moreover,
inhibition
reduces
ameliorates
conclusion,
promotes
increasing
expression,
indicating
may
be
therapeutic
target
for
International Reviews of Immunology,
Год журнала:
2023,
Номер
43(3), С. 160 - 177
Опубликована: Ноя. 17, 2023
Autoimmune
diseases
such
as
rheumatoid
arthritis
(RA),
systemic
lupus
erythematosus
(SLE),
and
inflammatory
bowel
disease
(IBD)
are
caused
by
the
body's
immune
response
to
autoantigens.
The
pathogenesis
of
autoimmune
is
unclear.
Numerous
studies
have
demonstrated
that
RNA
methylation
plays
a
key
role
in
progression,
which
essential
for
post-transcriptional
regulation
has
gradually
become
broad
regulatory
mechanism
controls
gene
expression
various
physiological
processes,
including
nuclear
output,
translation,
splicing,
noncoding
processing.
Here,
we
outline
writers,
erasers,
readers
methylation,
N6-methyladenosine
(m6A),
2'-O-methylation
(Nm),
2′-O-dimethyladenosine
(m6Am),
N1-methyladenosine
(m1A),
5-methylcytidine
(m5C)
N7-methylguanosine
(m7G).
As
modifications
system
explained,
potential
treatment
value
these
also
been
demonstrated.
This
review
reports
relationship
between
diseases,
highlighting
need
future
research
into
therapeutic
modifications.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Апрель 17, 2024
Abstract
Ischemic
stroke
(IS)
is
a
common
cerebrovascular
disease
whose
pathogenesis
involves
variety
of
immune
molecules,
channels
and
processes.
6-methyladenosine
(m6A)
modification
regulates
metabolic
immunopathological
processes,
but
the
role
m6A
in
IS
not
yet
understood.
We
downloaded
data
set
GSE58294
from
GEO
database
screened
for
m6A-regulated
differential
expression
genes.
The
RF
algorithm
was
selected
to
screen
key
regulatory
Clinical
prediction
models
were
constructed
validated
based
on
patients
grouped
according
genes,
markers
identified
infiltration
characteristics
correlation.
Finally,
we
performed
functional
enrichment,
protein
interaction
network
analysis
molecular
biomarkers.
total
7
differentially
expressed
genes
dataset,
namely
METTL3,
WTAP,
YWHAG,
TRA2A,
YTHDF3,
LRPPRC
HNRNPA2B1.
random
forest
indicated
that
all
IS,
credibility
above
verified
by
constructing
clinical
model.
Based
divided
into
2
groups.
gene
correlation
under
different
subgroups,
as
an
biomarker
IS.
GO
enrichment
analyses
indicate
associated
with
cellular
functions.
Protein
correlates
proteins,
may
serve
target
drug
therapy.
Our
findings
suggest
marker
Further
could
elucidate
its
microenvironment
