Cardiovascular health of patients with cancer: Challenges abound

Trends in Cardiovascular Medicine, Год журнала: 2024, Номер unknown

Опубликована: Апрель 1, 2024

Patients with cancer have elevated cardiovascular risks compared to those without cancer. As incidence increases and cancer-related mortality decreases, diseases in patients a history of will become increasingly important. This turn is reflected by the exponentially increasing amount cardio-oncology research recent years. narrative review aims summarize key existing literature several main areas cardio-oncology, including epidemiology, natural history, prevention, management, determinants health cancer, identify relevant gaps evidence for further research.

Язык: Английский

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Gut dysbiosis impacts the immune system and promotes prostate cancer

Immunology Letters, Год журнала: 2024, Номер 268, С. 106883 - 106883

Опубликована: Июнь 12, 2024

Язык: Английский

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Rising mortality related to cardiovascular disease and prostate cancer amongst older men across the United States

Current Problems in Cardiology, Год журнала: 2024, Номер 49(11), С. 102785 - 102785

Опубликована: Авг. 8, 2024

There is a significant association between cardiovascular diseases (CVD) and prostate cancer (PCa), leading to high mortality. This study evaluates the trends in mortality associated with CVDs PCa among older (≥ 65 years) men United States (US).

Язык: Английский

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Comprehensive review of cardiovascular disease in prostate cancer: epidemiology, risk factors, therapeutics and prevention strategies

Prostate Cancer and Prostatic Diseases, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Язык: Английский

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Race and Ethnicity, Lifestyle, Diet, and Survival in Patients With Prostate Cancer

JAMA Network Open, Год журнала: 2025, Номер 8(2), С. e2460785 - e2460785

Опубликована: Фев. 26, 2025

Importance Prostate cancer (PCa) remains a leading cause of cancer-related death among men in the US. Objective To evaluate association healthy lifestyle and dietary behaviors with survival after nonmetastatic PCa diagnosis multiethnic population. Design, Setting, Participants This prospective cohort study was conducted aged 45 to 75 years enrolled between 1993 1996 Multiethnic Cohort study. completed questionnaire (2003-2008) were followed up until or loss follow-up. Data analyzed from January 10, 2023, May 20, 2024. Exposures Lifestyle patterns assessed using 3 behavior scores 13 indices (4 prioritized scores: Healthy Eating Index–2015, Healthful Plant-Based Diet Index, Dietary Inflammatory Empirical Index for Hyperinsulinemia). Main Outcomes Measures Cox proportional hazards models used multivariable-adjusted associations each score all-cause, cardiovascular disease (CVD), PCa-specific mortality. Results A total 2603 (mean [SD] age, 69.6 [7.1] years) up, 1346 deaths documented, including 356 (24.6%) CVD 197 (14.6%) PCa. The median (IQR) follow-up 10.9 (IQR, 6.8-12.7) return 14.5 11.8-18.0) diagnosis. 2021 Behavior Score associated reduced risks all-cause (hazard ratio [HR] per point, 0.69; 95% CI, 0.63-0.77) CVD-related (HR, 0.67; 0.56-0.79) also lower risk mortality African American 0.46; 0.24-0.88) but not other racial ethnic groups. Comparing quintile 5 (highest score) 1 (lowest score), Hyperinsulinemia positively 1.37; 1.02-1.84) 1.96; 1.15-3.33) mortality, whereas 0.75; 0.58-0.97); findings statistically significant 0.44-1.03). No found Conclusions Relevance In this patients PCa, healthier lifestyles improved overall survival. Given predominance non–PCa-specific deaths, these support need health counseling treat comorbidities

Язык: Английский

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The Impact of Prostate-Specific Antigen and Gleason Scores on Cardiovascular Death in Prostate Cancer Patients after Radiotherapy or Chemotherapy: A Population-Based Study

Reviews in Cardiovascular Medicine, Год журнала: 2025, Номер 26(2)

Опубликована: Фев. 19, 2025

Background: Tumor characteristics are associated with the risk of cardiovascular death (CVD) in cancer patients. However, influence tumor on CVD among prostate (PC) patients who have received radiotherapy (RT) or chemotherapy (CT) is often overlooked. This study explored association between PC and had RT CT. Methods: Fine-gray competitive analysis was employed to identify factors. Sensitivity analyses were conducted adjust for confounding The predicted prostate-specific antigen (PSA) Gleason score values visualized using a nomogram, which subsequently validated through calibration curves concordance indexes (C-indexes). Results: A total 120,908 enrolled study, mean follow-up time 80 months. PSA 10 20 ng/mL (adjusted hazard ratio (HR): 1.28, 95% confidence interval (CI): 1.20–1.36, p < 0.001) >20 HR: 1.27, CI: 1.21–1.35, 0.001), >7 1.23, 1.07–1.41, = 0.004) identified as factors after C-index training cohort 0.66 (95% 0.66–0.67), validation 0.67 0.65–0.68). Consistency observed actual observations nomogram. Risk stratification also significant (p 0.001). Conclusions: ≥10 scores may be an increased These require more long-term monitoring risk.

Язык: Английский

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Hemoglobin A1c stratifies risk of adverse cardiovascular outcomes in prostate cancer survivors in the UK Biobank: a cohort study

Cardio-Oncology, Год журнала: 2025, Номер 11(1)

Опубликована: Апрель 10, 2025

Cardiovascular mortality is a major cause of death in prostate cancer (PCa) survivors, yet tools for cardiovascular risk stratification this population are lacking. Although hemoglobin A1c (HbA1c) routinely utilized the general population, value HbA1c patients with PCa unknown. Leveraging data from UK Biobank, we analyzed association and adverse outcomes 2,270 men diagnosed PCa. Over median follow-up 13.4 (IQR 1.7) years, 172 or non-fatal myocardial infarction (MI) events occurred. When compared to participants an < 5.7% competing-risk regression analysis accounting non-cardiovascular death, ≥ 6.5% was strongest predictor MI (sHR 1.88, 95% CI 1.01-3.48, P 0.001) after insulin use model adjusted demographics, traditional factors, use. Furthermore, when age-matched male Biobank without PCa, continuous levels were stronger survivors (P-interaction = 0.011). Our findings highlight as robust Further prospective studies needed discern if improving glycemic control could decrease population.

Язык: Английский

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Flare phenomenon visualized by 99mTc-bone scintigraphy has prognostic value for patients with metastatic castration-resistant prostate cancer

Annals of Nuclear Medicine, Год журнала: 2024, Номер 38(6), С. 428 - 440

Опубликована: Март 13, 2024

Abstract Objective This study aimed to determine the prognostic value of flare phenomenon in patients with metastatic castration-resistant prostate cancer (mCRPC) using bone scan index (BSI) derived from 99m Tc-methylenediphosphonate (MDP) scintigraphy images. Methods We categorized 72 PROSTAT-BSI registry mCRPC who were followed-up for 2 years after starting docetaxel chemotherapy groups based on pre-chemotherapy BSI values < 1, 1–4, and > 4. assessed effects (defined as a 10% increase within 3 months chemotherapy, followed by improvement next months) survival Kaplan–Meier curves Cox proportional hazard analyses. Results The was found 26 (36%) patients. Prostate-specific antigen (PSA), alkaline phosphatase (ALP), hemoglobin (Hb) levels steadily increased, then deteriorated without flare, respectively. Elevated PSA at therapy absence abiraterone or/and enzalutamide led poor 2-year overall (OS) group flare. In contrast, no influence noticeable results multivariable analyses that included only factors associated showed increased baseline (hazard ratio [HR], 1.39; 95% confidence interval [CI], 1.04–1.86; P = 0.023) (HR, 7.15; CI 2.13–24.04; 0.0015) could be independent risk However, these lost significance during all-cause death significantly higher among 4 without, than univariable indicated positively impacted 0.24; 0.06‒0.91; 0.035). Multivariable analysis did not identify any predict outcomes. Conclusion Favorable prognosis, fewer disturbances other such use enzalutamide, changes, BSI, attainable cases when patient demonstrated phenomenon. Follow-up least every help prognosis metastasis mCRPC.

Язык: Английский

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Health Literacy, Individual and Community Engagement, and Cardiovascular Risks and Disparities

JACC CardioOncology, Год журнала: 2024, Номер 6(3), С. 363 - 380

Опубликована: Май 7, 2024

Cardiovascular and cancer outcomes intersect within the realm of cardio-oncology survivorship care, marked by disparities across ethnic, racial, social, geographical landscapes. Although clinical community is increasingly aware this complex issue, effective solutions are trailing. To attain substantial public health impact, examinations types cardiovascular risk mitigation require complementary approaches that elicit patient's perspective, scale it to a population level, focus on actionable interventions. Adopting such multidisciplinary approach will deepen our understanding patient awareness, motivation, literacy, resources for addressing unique challenges cardio-oncology. Geospatial analysis aids in identifying key communities need both granular broader contexts. In review, we delineate pathway navigates barriers from individual levels. Data gleaned these perspectives critical informing interventions empower individuals diverse improve survivorship.

Язык: Английский

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Effects of high-intensity interval training on cardiometabolic biomarkers in patients with prostate cancer undergoing active surveillance: a randomized controlled trial

Prostate Cancer and Prostatic Diseases, Год журнала: 2024, Номер unknown

Опубликована: Июль 15, 2024

Язык: Английский

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