Objective Detection of Chronic Infection-Acquired Physiological Changes via Wearables: Potential Implications for Long COVID

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to post-acute sequelae of SARS-CoV-2 (PASC), or Long COVID, a chronic multisystemic condition with diverse symptoms and no objective diagnostic test. In this study, we developed data-driven method objectively detect persistent physiological changes post-COVID-19 using wearable device data. We analyzed data from 663 symptomatic COVID-19-positive cases 2,513 asymptomatic COVID-19-negative controls. Our identified alterations in 9.4% individuals, aligning previous COVID prevalence estimates. Additionally, vaccination reduced the risk these by ~ 40%. Affected individuals exhibited elevated resting heart rates rate variability. findings highlight potential technology identifying monitoring post-infection, offering scalable tool for assessment. This approach could enhance clinical evaluation personalized management cases.

Язык: Английский

---

Comparative analysis of the impact of self-reported physical activity on heart rate variability in exposed and nonexposed Individuals to COVID-19: A retrospective study

Medicine, Год журнала: 2025, Номер 104(18), С. e42345 - e42345

Опубликована: Май 2, 2025

The COVID-19 pandemic has raised critical concerns about its long-term effects on cardiovascular health, particularly concerning autonomic nervous system (ANS) function. Little is known the differences in ANS function between physically active and inactive individuals exposed nonexposed to COVID-19. This study aimed compare impact of self-reported physical activity using heart rate variability (HRV) metrics In total 142 participants from Riyadh region, Saudi Arabia, were divided into (n = 70) 71) groups based their exposure. HRV was assessed photoplethysmography analyzed time frequency domains. Physical simple yes or no question, duration categorized less than 30 minutes, more minutes. Physically generally exhibited higher metrics, suggesting better function, although this effect pronounced group. Interestingly, low-frequency high-frequency ratio only metric that showed a statistically significant difference group ( P .04). There reported either COVID-19-exposed groups. underscored importance monitoring health post-COVID-19 populations suggested while beneficial, virus may blunted benefits. Further research needed explore implications potential for mitigate these effects.

Язык: Английский

---

Autonomic Dysfunction and Low Cardio-Respiratory Fitness in Long-Term Post-COVID-19 Syndrome

Biomedicines, Год журнала: 2025, Номер 13(5), С. 1138 - 1138

Опубликована: Май 8, 2025

Purpose: Post-COVID-19 syndrome (PCS) is characterized by low cardio-respiratory fitness (CRF). Recent research focuses on the role of autonomic nervous system dysfunction (AD) as a potential contributor to diminished exercise performance. The aim determine prevalence AD—chronotropic insufficiency (CI) and abnormal heart rate recovery (HRR) in long-term PCS subjects analyse their association with capacity. Patients Methods: A total 192 history SARS-CoV-2 infection were included. Chronic Fatigue Syndrome Questionnaire (CFSQ) was applied, two symptomatic asymptomatic emerged. Forty-seven had post-COVID complaints, persisting up thirty months post-acute episode. CI HRR determined during cardio-pulmonary test (CPET). Results: Symptomatic divided into mild (20) moderate-severe (27), depending CFSQ score; forty-eight without complaints served control group. Subjects showed lower peak VO2 (24.13 ± 6.1 mL/min/kg vs. 26.73 5.9 mL/min/kg, 27.01 6.3 mL/min/kg), compared mild/asymptomatic subjects. Diminished physical activity established 10 (37%) moderate-severe, 7 (35%) mildly 14 (29%) groups. occurrence AD mild/moderate-severe groups were, respectively, 35% 81.5% 12.5%. Abnormal was, 20% 33% 8%. None depleted breathing reserve, dynamic hyperinflation, bronchospasm or desaturation. Neither nor correlated O2. Conclusions: present among may limit response but not independently associated it. Assuming multiorgan ANS innervation, it highly probable that has diverse pathological pathways various phenotypes contributes differently cerebral, cardiovascular, respiratory, peripheral mixed neuro-cognitive

Язык: Английский

---

Unraveling the Mechanisms Behind Exercise Intolerance and Recovery in Long COVID

The American Journal of Medicine, Год журнала: 2024, Номер unknown

Опубликована: Апрель 1, 2024

BackgroundPatients suffering from long COVID may exhibit autonomic dysregulation. However, the association between dysregulation and exercise intolerance impact of therapeutic interventions on its modulation remain unclear. This study investigated relationship heart rate recovery at first minute (HRR1), a proxy for imbalance, in patients with COVID. Additionally, aimed to assess effects 12-week home-based inspiratory muscle training program this patient population.MethodsThis is post hoc subanalysis randomized trial which 26 were randomly assigned receive either or usual care alone (NCT05279430). The data analyzed using Pearson's correlation linear mixed regression analysis.ResultsThe mean age was 50.4±12.2 years, 11 (42.3%) women. Baseline HRR1 significantly correlated maximal functional capacity (peakVO2) (r=0.402, p=0.041). Patients lower baseline (≤ 22 bpm) exhibited higher resting rates peakVO2. Inspiratory led more substantial increase peakVO2 (p=0.019). significant improvement observed IMT group compared after (Δ +9.39, 95% CI=2.4-16.4, p=0.010).ConclusionLower associated serve as valuable criterion identifying individuals likely benefit program.

Язык: Английский

---

Effects of Probiotics on Inflammatory Biomarkers and Its Associations With Cardiac Autonomic Function in Women With Arterial Hypertension: A Secondary Analysis of a Randomized Clinical Trial

Probiotics and Antimicrobial Proteins, Год журнала: 2024, Номер unknown

Опубликована: Июнь 6, 2024

Язык: Английский

---

Pooled rates and demographics of POTS following SARS-CoV-2 infection versus COVID-19 vaccination: Systematic review and meta-analysis

Autonomic Neuroscience, Год журнала: 2023, Номер 250, С. 103132 - 103132

Опубликована: Ноя. 23, 2023

Язык: Английский

---

Cardiopulmonary exercise testing in long covid shows the presence of dysautonomia or chronotropic incompetence independent of subjective exercise intolerance and fatigue

BMC Cardiovascular Disorders, Год журнала: 2024, Номер 24(1)

Опубликована: Авг. 8, 2024

Abstract Background After COVID-19 infection, 10–20% of patients suffer from varying symptoms lasting more than 12 weeks (Long COVID, LC). Exercise intolerance and fatigue are common in LC. The aim was to measure the maximal exercise capacity LC with these analyze whether this related heart rate (HR) responses at rest during recovery, find out possible sympathetic overactivity, dysautonomia or chronotropic incompetence. Methods Cardiopulmonary test conducted on 101 patients, who were admitted testing. majority them (86%) had been treated home their acute infection. Peak oxygen uptake (VO2peak), power last 4 min (Wlast4), HRs, other variables compared between those without subjective intolerance, fatigue, both. Results measurements performed mean 12.7 months (SD 5.75) after infection (group EI, 19 patients), F, 31 combination EI + 37 neither N, 14 patients). was, mean, normal all symptom groups did not significantly differ among them. HRs higher group F N maximum (169/min vs. 158/min, p = 0.034) 10 (104/min 87/min, 0.028). Independent symptoms, filled criteria associated slightly decreased Wlast4 (73% 91% sex, age, height, weight-based reference values 0.017) 13 incompetence lowest (63% 93%, < 0.001), VO2peak (70% 94%, increase systolic blood pressure (50 mmHg 67 mmHg, greatest prevalence slight ECG-findings ( features. highest seen 0.022). Conclusions This study different showed that cardiopulmonary normal, increased activity most patients. However, we identified subgroups a lowered as measured by VO2peak. Subjective poorly foresaw level capacity. results could be used plan rehabilitation for selection suitable it.

Язык: Английский

---

Evidence-Based Clinical Utility of Heart Rate Variability Across Populations, Including Long COVID

Cardiopulmonary Physical Therapy Journal, Год журнала: 2024, Номер unknown

Опубликована: Дек. 3, 2024

Purpose: Heart rate variability (HRV) has been used for decades as a tool measuring systemic health through the autonomic nervous system (ANS). The purpose of this paper was to examine literature on HRV and investigate its use in long COVID (LC) population. Summary Key Points: Measurement devices vary significantly their validity reliability when compared with gold standard electrocardiogram (ECG). Wrist hand typically demonstrate diminished capturing signal, while chest strap often exhibit high validity. Lack transparency third-party software clean analyze data makes assessment accuracy problematic. This is particular concern single beat miscalculations can result dissimilar output. conditions under which are collected, such natural or paced breathing, activity intensity, patient position, dramatically affect readings. While some individual metrics have consistently shown reflect certain components ANS, high-frequency power measure parasympathetic function, meaning other less clear. Recommendations Clinical Practice: be an extraordinarily valuable function. However, it recommended that clinicians judicious interpretation HRV, considering inconsistencies presentation. particularly true LC, where varies greatly. In all populations, should consider using valid assess trends values over time, along consideration unique physical conditions.

Язык: Английский

---

The negative effects of long COVID-19 on cardiovascular health and implications for the presurgical examination

Journal of Osteopathic Medicine, Год журнала: 2024, Номер unknown

Опубликована: Окт. 17, 2024

In 2019, emergence of the novel and communicable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection took scientific communities by surprise imposed significant burden on healthcare systems globally. Although advent this disease piqued interest academic centers, systems, general public, there is still much yet to be elucidated regarding epidemiology, pathophysiology, long-term impacts 2019 (COVID-19). It has been established that long COVID-19 can impact multiple organ including cardiovascular system, unfavorably. pathophysiology damage not well understood, adverse sequelae may range from chest pain arrhythmias heart failure (HF), myocardial infarction, or sudden cardiac death. For any postacute patient requiring a surgical procedure, potential for injury secondary must considered in preoperative examination.

Язык: Английский

---

Vagus nerve stimulation for long COVID

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 383 - 392

Опубликована: Ноя. 22, 2024

Язык: Английский

---