Biology Bulletin Reviews, Год журнала: 2024, Номер 14(4), С. 434 - 439
Опубликована: Июль 26, 2024
Язык: Английский
BioMedical Engineering OnLine, Год журнала: 2025, Номер 24(1)
Опубликована: Фев. 3, 2025
Abstract Background Coronavirus disease 19 (COVID-19) patients might develop sequelae after apparent resolution of the infection. Autonomic dysfunction and baroreflex failure have been frequently reported. However, long-term effect COVID-19 on cardiorespiratory cardiovascular neural controls has not investigated with directional approaches able to open closed-loop relationship between physiological variables. Methods A model-based causal spectral approach, namely squared coherence (CK 2 ), was applied beat-to-beat variability series heart period (HP) systolic arterial pressure (SAP), respiratory signal (RESP) acquired at rest in supine position during active standing (STAND) survivors 9 months their hospital discharge. Patients were categorized according need ventilatory support hospitalization as individuals that had no continuous positive airway (noCPAP, n = 27), sub-intensive care unit (CPAP, 14) invasive mechanical ventilation intensive (IMV, 8). Results The expected decrease strength HP-RESP dynamic interactions well increase dependence HP SAP along STAND observed this result held regardless severity disease, noCPAP, CPAP IMV cohorts. Regardless experimental condition, causality markers did vary across groups either. Conclusions CK markers, association an orthostatic challenge, characterize impairment control long acute infection could be exploited monitor evolution
Язык: Английский
Процитировано
0
Cureus, Год журнала: 2025, Номер unknown
Опубликована: Март 31, 2025
Post-acute sequelae of SARS-CoV-2 (PASC), or Long COVID, is a multi-system disorder often involving dysautonomia and pain, linked to persistent sympathetic nervous system hyperactivity. Dual blocks (DSBs), including stellate ganglion (SGBs), are minimally invasive procedures that may recalibrate dysregulated signaling alleviate PASC symptoms. This open-label, non-randomized pilot study included 20 participants with experiencing pain autonomic Participants received right-sided left-sided SGB one week apart. Symptoms were assessed at baseline, one, four using the Composite Autonomic Symptom Score (COMPASS-31) Patient-Reported Outcomes Measurement Information System (PROMIS-29) scales. Seventeen completed study, demonstrating significant improvements in dysfunction (38.4% reduction COMPASS-31 scores, p = 0.0016) interference (48.4% reduction, < 0.001) by four. Improvements sleep quality fatigue also (p 0.016 0.049, respectively). Overall, 88.2% reported symptom relief, no adverse events observed. DSBs appear be promising intervention for PASC-related pain. These findings warrant further investigation larger, randomized controlled trials confirm efficacy explore underlying mechanisms.
Язык: Английский
Процитировано
0
Medicine, Год журнала: 2025, Номер 104(18), С. e42345 - e42345
Опубликована: Май 2, 2025
The COVID-19 pandemic has raised critical concerns about its long-term effects on cardiovascular health, particularly concerning autonomic nervous system (ANS) function. Little is known the differences in ANS function between physically active and inactive individuals exposed nonexposed to COVID-19. This study aimed compare impact of self-reported physical activity using heart rate variability (HRV) metrics In total 142 participants from Riyadh region, Saudi Arabia, were divided into (n = 70) 71) groups based their exposure. HRV was assessed photoplethysmography analyzed time frequency domains. Physical simple yes or no question, duration categorized less than 30 minutes, more minutes. Physically generally exhibited higher metrics, suggesting better function, although this effect pronounced group. Interestingly, low-frequency high-frequency ratio only metric that showed a statistically significant difference group ( P .04). There reported either COVID-19-exposed groups. underscored importance monitoring health post-COVID-19 populations suggested while beneficial, virus may blunted benefits. Further research needed explore implications potential for mitigate these effects.
Язык: Английский
Процитировано
0
Biomedicines, Год журнала: 2025, Номер 13(5), С. 1138 - 1138
Опубликована: Май 8, 2025
Purpose: Post-COVID-19 syndrome (PCS) is characterized by low cardio-respiratory fitness (CRF). Recent research focuses on the role of autonomic nervous system dysfunction (AD) as a potential contributor to diminished exercise performance. The aim determine prevalence AD—chronotropic insufficiency (CI) and abnormal heart rate recovery (HRR) in long-term PCS subjects analyse their association with capacity. Patients Methods: A total 192 history SARS-CoV-2 infection were included. Chronic Fatigue Syndrome Questionnaire (CFSQ) was applied, two symptomatic asymptomatic emerged. Forty-seven had post-COVID complaints, persisting up thirty months post-acute episode. CI HRR determined during cardio-pulmonary test (CPET). Results: Symptomatic divided into mild (20) moderate-severe (27), depending CFSQ score; forty-eight without complaints served control group. Subjects showed lower peak VO2 (24.13 ± 6.1 mL/min/kg vs. 26.73 5.9 mL/min/kg, 27.01 6.3 mL/min/kg), compared mild/asymptomatic subjects. Diminished physical activity established 10 (37%) moderate-severe, 7 (35%) mildly 14 (29%) groups. occurrence AD mild/moderate-severe groups were, respectively, 35% 81.5% 12.5%. Abnormal was, 20% 33% 8%. None depleted breathing reserve, dynamic hyperinflation, bronchospasm or desaturation. Neither nor correlated O2. Conclusions: present among may limit response but not independently associated it. Assuming multiorgan ANS innervation, it highly probable that has diverse pathological pathways various phenotypes contributes differently cerebral, cardiovascular, respiratory, peripheral mixed neuro-cognitive
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(11), С. 5102 - 5102
Опубликована: Май 26, 2025
Cognitive dysfunction represents one of the most persistent and disabling features Long COVID, yet its molecular underpinnings remain incompletely understood. This narrative review synthesizes current evidence on pathophysiological mechanisms linking SARS-CoV-2 infection to long-term neurocognitive sequelae. Key processes include neuroinflammation, blood–brain barrier (BBB) disruption, endothelial dysfunction, immune dysregulation, neuroendocrine imbalance. Microglial activation cytokine release (e.g., IL-6, TNF-α) promote synaptic neuronal injury, while inflammasomes such as NLRP3 amplifies CNS inflammation. Vascular abnormalities, including microthrombosis BBB leakage, facilitate infiltration peripheral cells neurotoxic mediators. Hypothalamic–pituitary–adrenal axis reduced vagal tone further exacerbate systemic inflammation autonomic Biomarkers GFAP, NFL, S100B have been associated with both neuroinflammation cognitive symptoms. Notably, transcriptomic signatures in COVID overlap those observed Alzheimer’s disease, highlighting shared pathways involving tau oxidative stress, glial reactivity. Understanding these is critical for identifying at-risk individuals developing targeted therapeutic strategies. underscores need longitudinal research integrative biomarker analysis elucidate trajectory impairment COVID.
Язык: Английский
Процитировано
0
Autonomic Neuroscience, Год журнала: 2023, Номер 250, С. 103132 - 103132
Опубликована: Ноя. 23, 2023
Язык: Английский
Процитировано
7
Probiotics and Antimicrobial Proteins, Год журнала: 2024, Номер unknown
Опубликована: Июнь 6, 2024
Язык: Английский
Процитировано
2
BMC Cardiovascular Disorders, Год журнала: 2024, Номер 24(1)
Опубликована: Авг. 8, 2024
Abstract Background After COVID-19 infection, 10–20% of patients suffer from varying symptoms lasting more than 12 weeks (Long COVID, LC). Exercise intolerance and fatigue are common in LC. The aim was to measure the maximal exercise capacity LC with these analyze whether this related heart rate (HR) responses at rest during recovery, find out possible sympathetic overactivity, dysautonomia or chronotropic incompetence. Methods Cardiopulmonary test conducted on 101 patients, who were admitted testing. majority them (86%) had been treated home their acute infection. Peak oxygen uptake (VO2peak), power last 4 min (Wlast4), HRs, other variables compared between those without subjective intolerance, fatigue, both. Results measurements performed mean 12.7 months (SD 5.75) after infection (group EI, 19 patients), F, 31 combination EI + 37 neither N, 14 patients). was, mean, normal all symptom groups did not significantly differ among them. HRs higher group F N maximum (169/min vs. 158/min, p = 0.034) 10 (104/min 87/min, 0.028). Independent symptoms, filled criteria associated slightly decreased Wlast4 (73% 91% sex, age, height, weight-based reference values 0.017) 13 incompetence lowest (63% 93%, < 0.001), VO2peak (70% 94%, increase systolic blood pressure (50 mmHg 67 mmHg, greatest prevalence slight ECG-findings ( features. highest seen 0.022). Conclusions This study different showed that cardiopulmonary normal, increased activity most patients. However, we identified subgroups a lowered as measured by VO2peak. Subjective poorly foresaw level capacity. results could be used plan rehabilitation for selection suitable it.
Язык: Английский
Процитировано
2
Cardiopulmonary Physical Therapy Journal, Год журнала: 2024, Номер unknown
Опубликована: Дек. 3, 2024
Purpose: Heart rate variability (HRV) has been used for decades as a tool measuring systemic health through the autonomic nervous system (ANS). The purpose of this paper was to examine literature on HRV and investigate its use in long COVID (LC) population. Summary Key Points: Measurement devices vary significantly their validity reliability when compared with gold standard electrocardiogram (ECG). Wrist hand typically demonstrate diminished capturing signal, while chest strap often exhibit high validity. Lack transparency third-party software clean analyze data makes assessment accuracy problematic. This is particular concern single beat miscalculations can result dissimilar output. conditions under which are collected, such natural or paced breathing, activity intensity, patient position, dramatically affect readings. While some individual metrics have consistently shown reflect certain components ANS, high-frequency power measure parasympathetic function, meaning other less clear. Recommendations Clinical Practice: be an extraordinarily valuable function. However, it recommended that clinicians judicious interpretation HRV, considering inconsistencies presentation. particularly true LC, where varies greatly. In all populations, should consider using valid assess trends values over time, along consideration unique physical conditions.
Язык: Английский
Процитировано
2
Journal of Osteopathic Medicine, Год журнала: 2024, Номер unknown
Опубликована: Окт. 17, 2024
In 2019, emergence of the novel and communicable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection took scientific communities by surprise imposed significant burden on healthcare systems globally. Although advent this disease piqued interest academic centers, systems, general public, there is still much yet to be elucidated regarding epidemiology, pathophysiology, long-term impacts 2019 (COVID-19). It has been established that long COVID-19 can impact multiple organ including cardiovascular system, unfavorably. pathophysiology damage not well understood, adverse sequelae may range from chest pain arrhythmias heart failure (HF), myocardial infarction, or sudden cardiac death. For any postacute patient requiring a surgical procedure, potential for injury secondary must considered in preoperative examination.
Язык: Английский
Процитировано
1