International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2846 - 2846

Опубликована: Фев. 29, 2024

The treatment of patients with advanced cancer poses clinical problems due to the complications that arise as disease progresses. Bone metastases are a common problem may face, and currently, there no effective drugs treat these individuals. Prostate, breast, lung cancers often spread bone, causing significant disabling health conditions. bone is highly active dynamic tissue considered favorable environment for growth cancer. role osteoblasts osteoclasts in process remodeling way which their interactions change during progression metastasis critical understanding pathophysiology this disease. These create self-perpetuating loop stimulates metastatic cells bone. metabolic reprogramming both microenvironment has serious implications development metastasis. Insight into systemic elements regulate process, well cellular changes occur metastases, discovery cure It crucial explore different therapeutic options focus specifically on malignancy order effectively This review will effects disorders factors like hormones cytokines metastases. We also examine various alternatives available today upcoming advances novel treatments.

Язык: Английский