Use of combination therapy is associated with improved LDL cholesterol management: 1-year follow-up results from the European observational SANTORINI study

European Journal of Preventive Cardiology, Год журнала: 2024, Номер 31(15), С. 1792 - 1803

Опубликована: Июнь 11, 2024

Abstract Aims To assess whether implementation of the 2019 European Society Cardiology (ESC)/European Atherosclerosis (EAS) dyslipidaemia guidelines observed between 2020 and 2021 improved 2022 in SANTORINI study. Methods results Patients with high or very cardiovascular (CV) risk were recruited across 14 countries from March to February 2021, 1-year prospective follow-up until May 2022. Lipid-lowering therapy (LLT) ESC/EAS risk-based low-density lipoprotein (LDL) cholesterol (LDL-C) goal attainment (defined as <1.4 mmol/L for patients at CV <1.8 risk) compared baseline. Of 9559 enrolled, 9136 (2626 6504 had any available data, 7210 (2033 5173 baseline LDL-C data. was escalated one-third unchanged two-thirds. Monotherapy combination usage rose 53.6 25.6% 57.1 37.9%, respectively. Mean levels decreased 2.4 2.0 mmol/L. Goal 21.2 30.9%, largely driven by LLT use among those not on greater monotherapy (39.4 vs. 25.5%). Conclusion achievement lipid goals increased over particularly when used. Nonetheless, most remained above goal; hence, strategies are needed improve LLT.

Язык: Английский

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Pre- and post-pandemic comparisons in cardiovascular markers: a population-based study

Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 11

Опубликована: Янв. 14, 2025

The COVID-19 pandemic, starting in 2020, raised concerns about potential long-term health impacts, including its effects on cardiovascular and related biomarkers. This study part of the Bus Santé Geneva, Switzerland, compared metabolic profiles pre- (2016-2019) post-pandemic (2023-2024) among individuals aged 30-75. Participants completed questionnaires underwent a clinical visit, physical examination fasting blood test to assess lipid glycemic profiles. Linear regression was used estimate results mean systolic diastolic pressure, cholesterol, profiles, after adjusting for age, sex, smoking, socioeconomic status. Quantile models were median values. A total 4,558 participants included. observed modest declines glucose, HDL, LDL levels post-pandemic, with stable pressure. prevalence treatment rates diabetes, hypertension, dyslipidemia remained consistent. Unawareness these conditions stable. Despite initial fears pandemic-induced debt, indicate healthy likely driven by improved lifestyle behaviors. highlights importance monitoring suggests that improvements may offset adverse pandemic developed nations like Switzerland.

Язык: Английский

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Amniotic fluid-derived mesenchymal stem cells as a therapeutic tool against cytokine storm: a comparison with umbilical cord counterparts

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Март 28, 2025

Several immunosuppressive therapies have been proposed as key treatment options for critically ill patients since the first appearance of severe acute respiratory syndrome coronavirus 2. Mesenchymal stem cells (MSCs) from different sources considered their potential to attenuate cytokine storm associated COVID-19 and consequent multi-organ failure, providing evidence safe efficacious treatments. Among them, administration umbilical cord-derived MSCs (UC-MSCs) has demonstrated a significant increase in survival rates, largely due potent properties. We applied next-generation sequencing (NGS) analysis compare transcriptomic profiles isolated two gestational sources: amniotic fluid (AF) obtained during prenatal diagnosis clinically relevant cord counterparts, which datasets were publicly available. A full meta-analysis was performed identify suitable GEO NGS comparison between AF- UC-MSC samples. Transcriptome revelaed differences groups, despite both cell lines being strongly involved tissue development, crucial achieve complex task wound healing. Significantly enriched hallmark genes suggest AF-MSC superior immunomodulatory features against signaling pathways actively (i.e., IL-2/STAT, TNF-a/NFkB, IL-2/STAT5, PI3K/AKT/mTOR). The data presented here that AF-MSCs hold promise treating not only COVID-19-associated storms but also variety other inflammatory syndromes those induced by bacterial infections, autoimmune disorders, therapeutic interventions). Realizing comprehensive approach disease management will require more extensive clinical trials in-depth mechanistic studies.

Язык: Английский

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National Trends in Heart Failure and Acute Myocarditis–Related Death Before and During the COVID‐19 Pandemic

Journal of the American Heart Association, Год журнала: 2025, Номер unknown

Опубликована: Май 15, 2025

Background The COVID‐19 pandemic saw a rise in cardiovascular death, likely the result of disruptions health care delivery and infection itself. We examine mortality trends heart failure (HF) acute myocarditis (AM) before during identify most affected demographic subgroups. Methods Results queried Centers for Disease Control Prevention Wide‐Ranging Online Data Epidemiologic Research database deaths from HF AM (1999–2019) (2020–2021) pandemic. Age‐adjusted rates were calculated stratified by sex, race ethnicity, age category. Trend‐level analysis was performed using Joinpoint Regression Program, which estimates average annual percentage change (AAPC) age‐adjusted rate with corresponding 95% CI. A total 7 366 944 33 750 occurred 1999 to 2021. downtrended (AAPC, −0.63 −2.42, respectively) but reversed (HF AAPC, 7.91; 20.3). Overall, pandemic, both greater men, non‐Hispanic Black people, adults aged ≥65 years. sharpest increase observed among American Indian people 14.9), Hispanic 9.63), young 20.9) women (AAPC 18.7), 15.6), older 23.5) AM. Conclusions prepandemic downward have since 2020. Subgroups that had greatest absolute years (aged years).

Язык: Английский

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From Inflammation to Acute Cardiovascular Events – a Complex Journey

Journal of Cardiovascular Emergencies, Год журнала: 2024, Номер 10(2), С. 58 - 60

Опубликована: Июнь 1, 2024

Inflammation is a major factor in the onset and progression of atherosclerosis, which currently considered chronic inflammatory disease.At endothelial level, inflammation leads to increased permeability lipoproteins their subendothelial accumulation, inducing dysfunction.The balance between pro-and anti-inflammatory properties determines atheroma progression. 1 The link long-term cardiovascular disease well-known, it has been demonstrated that can lead plaque vulnerabilization, triggering an acute coronary event.Moreover, systemic inflammation, such as one seen periodontal or COVID-19, correlated with atheromatous progression, favoring rupture thrombosis. 2 Diabetes mellitus also

Язык: Английский

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Mortality in Amputees with Peripheral Artery Disease during the Post-COVID Era: A Three-Year Analysis

Diseases, Год журнала: 2024, Номер 12(7), С. 133 - 133

Опубликована: Июнь 27, 2024

Background: Patients with peripheral artery disease (PAD) have 40–70% higher three-year mortality after lower limb amputation compared to non-amputees. In this study, we examined the consequences of delayed treatment for patients PAD during coronavirus 2019 (COVID-19) pandemic. Methods: This study employed a retrospective single-centre cohort design at large tertiary care hospital. We amputees initial COVID-19 outbreak period in 2020 control group from follow-up. Results: total, 134 were included due unsuccessful revascularization (n = 84 vs. n 50 2019). significantly younger than those (p 0.01) and mostly admitted advanced stages < 0.03). The proportion major amputations increased Non-COVID-19-related deaths among more twice as many 2019, long-term was 49% 39% 0.04). Diabetes renal insufficiency had negative impact on survival 0.01). Conclusions: Delayed leads high risk amputation, especially diabetes insufficiency. Therefore, future pandemics, continuously monitoring will be crucial prevent severe short-term consequences.

Язык: Английский

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Sampling approaches to reduce very frequent seasonal time series

Expert Systems, Год журнала: 2024, Номер unknown

Опубликована: Июль 25, 2024

Abstract With technological advancements, much data is being captured by sensors, smartphones, wearable devices, and so forth. These vast datasets are stored in centres utilized to forge data‐driven models for the condition monitoring of infrastructures systems through future mining tasks. However, these often surpass processing capabilities traditional information methodologies due their significant size. Additionally, not all samples within contribute valuable during model training phase, leading inefficiencies. The Machine Learning algorithms become time‐consuming, storing demands excessive space, contributing Big Data challenge. In this paper, we propose two novel techniques reduce large time‐series into more compact versions without undermining predictive performance resulting models. methods also aim decrease time required storage space needed condensed datasets. We evaluated our on five public datasets, employing three algorithms: Holt‐Winters, SARIMA, LSTM. outcomes indicate that most examined, maintain, several instances enhance, forecasting accuracy Moreover, significantly reduced train employed.

Язык: Английский

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High SARS-CoV-2 seroincidence but low excess COVID mortality in Sierra Leone in 2020–2022

PLOS Global Public Health, Год журнала: 2024, Номер 4(9), С. e0003411 - e0003411

Опубликована: Сен. 10, 2024

While SARS-CoV-2 infection appears to have spread widely throughout Africa, documentation of associated mortality is limited. We implemented a representative serosurvey in one city Sierra Leone Western paired with nationally and selected death registration data. Cumulative seroincidence using high quality serological assays was 69% by July 2021, rising 84% April 2022, mostly preceding vaccination. About half infections showed evidence neutralizing antibodies. However, excess rates were low, concentrated at older ages. During the peak weeks viral activity, 22% for individuals aged 30–69 years 70% those over 70. Based on electronic verbal autopsy dual independent physician assignment causes, deaths during peaks from respiratory notable. Excess differed little across specific causes that, priori, are COVID, pattern consistent among adults or without chronic disease risk factors. The overall 6% ages ≥30 2020–2022 markedly lower than reported South India, Latin America. Thus, while widespread, our study highlights as yet unidentified mechanisms heterogeneity susceptibility severe parts Africa.

Язык: Английский

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Relationship between COVID-19 cases and monthly mortality from all causes, cancer, cardiovascular diseases and diabetes in 16 countries, 2020–21

International Journal of Epidemiology, Год журнала: 2024, Номер 54(1)

Опубликована: Дек. 16, 2024

Abstract Background During the COVID-19 pandemic, mortality from some chronic diseases increased. In this study, we evaluated monthly excess all causes, cancer, cardiovascular (CVD) and diabetes during months of 2020 2021, examining its relationship with cases. Methods Monthly cause-specific data were downloaded public repositories national statistics offices or directly requested them, population obtained United Nations archives. Excess deaths estimated as difference between observed expected deaths. for 2021 calculated using a quasi-Poisson regression model trained on 2010–19 (or shorter timespan if full decade was not available). To quantify correlation cases mortality, used Spearman’s coefficient (rs). Results The study included 16 countries that provided causes death (Argentina, Austria, Brazil, Switzerland, Chile, Czech Republic, Germany, Georgia, Hungary, Italy, Lithuania, Latvia, Mexico, Serbia, Slovakia USA). A positive found in (rs ranging 0.61 to 0.91), CVD 11 0.45 0.85) 13 0.42 0.79). above 5% 14 both seven nine 12 2021. No cancer any considered. Conclusions persisted several throughout These increases coincide peaks, supporting short-term impact pandemic these causes.

Язык: Английский

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Trends in rheumatoid arthritis associated cardiovascular mortality in the United States from 1999 to 2020

Current Problems in Cardiology, Год журнала: 2024, Номер 49(7), С. 102607 - 102607

Опубликована: Апрель 30, 2024

Язык: Английский

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