New insights into healthy ageing, inflammageing and frailty using metabolomics

Frontiers in Aging, Год журнала: 2024, Номер 5

Опубликована: Июль 9, 2024

Human ageing is a normal process and does not necessarily result in the development of frailty. A mix genetic, environmental, dietary, lifestyle factors can have an impact on ageing, whether individual develops Frailty defined as loss physiological reserve both at physical cellular levels, where systemic processes such oxidative stress inflammation contribute to decline. The newest “omics” technology systems biology discipline, metabolomics, enables thorough characterisation small-molecule metabolites biological particular time condition. In system, metabolites—cellular intermediate products metabolic reactions—reflect system’s final response genomic, transcriptomic, proteomic, epigenetic, or environmental alterations. As relatively newer technique characterise biomarkers illness, metabolomics has gained popularity wide range applications. We will give comprehensive summary what currently known about studies with focus for Metabolites related amino acids, lipids, carbohydrates, redox metabolism may function and/or frailty development, based data obtained from human studies. However, there complexity that underpins due genetic play role orchestrating process. Therefore, critical need identify pathways functional decline people

Язык: Английский

Proteomic Analysis of Chronic Binge Alcohol-Induced Hippocampal and Anterior Cingulate Cortex Neuroadaptations in Simian Immunodeficiency Virus (SIV)-Infected Female Rhesus Macaques

Journal of Neuroimmune Pharmacology, Год журнала: 2025, Номер 20(1)

Опубликована: Фев. 10, 2025

Язык: Английский