Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 10, 2025

Arrhythmia, a common cardiovascular disorder, results from disturbances in cardiac impulse generation and conduction, leading to decreased output myocardial oxygenation, with potentially life-threatening consequences. Despite advancements therapeutic approaches, the incidence mortality associated arrhythmia remain high, drug-related adverse effects continue pose significant challenges. Traditional Chinese Medicine (TCM) has attracted considerable attention for its potential as complementary alternative approach treating diseases, including arrhythmia. Astragalus, prominent herb TCM, is commonly used clinical practice multi-faceted properties, encompassing anti-arrhythmic, cardiotonic, anti-inflammatory, immunomodulatory effects. Astragaloside IV, primary active compound Astragalus membranaceus , demonstrated cardioprotective through mechanisms such antioxidant, anti-apoptotic activities. Although evidence suggests that astragaloside IV holds promise treatment, comprehensive reviews of specific applications are scarce. This review systematically explores pharmacological properties underlying treatment. Utilizing targeted search databases PubMed, Web Science, Cochrane Library, Embase, CNKI, Wanfang Data, we summarize recent findings examine IV’s prevention Our analysis aims provide theoretical foundation development novel treatment strategies, while offering insights into future research directions application.

Язык: Английский