Archives of Pharmacy Practice, Год журнала: 2024, Номер 15(4), С. 53 - 57
Опубликована: Янв. 1, 2024
Язык: Английский
Pharmaceuticals, Год журнала: 2025, Номер 18(2), С. 147 - 147
Опубликована: Янв. 23, 2025
Hypertriglyceridemia (HTG) is associated with a residual risk of atherosclerotic cardiovascular disease. Extremely elevated triglyceride (TG) concentrations, particularly due to familial chylomicronemia syndrome (FCS), pose for acute pancreatitis. Standard therapies statins, fibrates, omega-3 fatty acids, and niacin may be insufficient reduce TG levels improve clinical outcomes in patients HTG. Novel antisense oligonucleotides small interfering ribonucleic acids target the key modulators TG-rich lipoprotein catabolism. Among apolipoprotein C-III (apoC-III) inhibitors, olezarsen plozasiran appear safer alternatives volanesorsen regarding drug-induced thrombocytopenia FCS or severe After failure vupanorsen, new angiopoietin-like protein 3 (ANGPTL3) inhibitor, zodasiran, demonstrated potential decrease moderate Meanwhile, fibroblast growth factor 21 (FGF21) analog, pegozafermin, became another candidate treatment This comprehensive review outlines pharmacological targets metabolism, discusses international guidelines, summarizes latest evidence from trials provide insight into current emerging options primary
Язык: Английский
Процитировано
1
Expert Opinion on Pharmacotherapy, Год журнала: 2024, Номер unknown
Опубликована: Сен. 21, 2024
Apolipoprotein (apo)C-III, a key regulator of plasma triglyceride (TG) levels, is prime candidate for the treatment hypertriglyceridemia (HTG), prevention acute pancreatitis, and reduction future atherosclerotic cardiovascular disease (ASCVD) events.
Язык: Английский
Процитировано
4
Drugs, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 12
Опубликована: Март 3, 2025
Atherosclerosis is a highly prevalent cardiovascular condition that affects individuals worldwide. Despite ongoing research into its treatment and prevention, atherosclerotic disease continues to exhibit high morbidity mortality rates. The accumulation of low-density lipoprotein cholesterol considered major contributor the development atherosclerosis, with abnormalities in lipid metabolism playing significant role pathogenesis. Lipid macrophage function are intricately interconnected, being influenced by inflammatory responses, while activity regulated alterations metabolism. interaction between these two processes plays critical progression atherosclerosis. Natural products have shown considerable promise treating variety diseases, including Moreover, modulation crosstalk represents key mechanism through which natural may exert their effects. This aims provide new insights current state on regulating this pathway interplay macrophages context offering potential directions for future.
Язык: Английский
Процитировано
0
Atherosclerosis, Год журнала: 2025, Номер unknown, С. 119186 - 119186
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Окт. 15, 2024
The ketogenic diet (KD) has been explored for diabetes management; however, a quantitative synthesis of its specific effects on not yet conducted. This study aims to examine the current status and research hotspots KD in management from 2005 2024, providing reference future research.
Язык: Английский
Процитировано
1
Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)
Опубликована: Дек. 18, 2024
Previous studies have established a correlation between elevated levels of remnant cholesterol (RC) and the occurrence type 2 diabetes mellitus (T2D) as well insulin resistance (IR); however, precise nature these associations remains incompletely elucidated. This study aimed to evaluate relationships RC IR, T2D, determine extent which IR mediated relationship T2D. was an observational that utilized cross-sectional methods examine general population in National Health Nutrition Examination Survey (NHANES) 1999–2020. The participants were divided into 4 groups according quartiles. outcome prevalence Survey-weighted binary logistic regression analysis used analyze associations, restricted cubic spline (RCS) curve further nonlinear relationship. Receiver operating characteristic (ROC) curves generated diagnostic performance, areas under (AUC) RC, low-density lipoprotein (LDL-C), high-density (HDL-C), triglycerides (TG) compared using DeLong test. mediating effect on T2D evaluated through mediation analysis. A total 23,755 (46.02 ± 18.48 years, 48.8% male) included our study. Higher significantly associated with increased both After adjusting for potential confounders, showed higher quartiles [Quartile vs. Quartile 1: odds ratio (OR) (95% confidence interval, CI): 1.65 (1.41–1.94), p < 0.001] OR 1.24 (1.03–1.50), = 0.024]. RCS revealed two distinct relationships: one (nonlinear 0.001), another 0.001). ROC demonstrated had highest discriminative ability, outperforming LDL-C, HDL-C, TG predicting risk (all P 0.001 by test). Mediation approximately 54.1% being indirect IR. level association suggesting managing could be crucial reducing individuals levels.
Язык: Английский
Процитировано
1
Archives of Pharmacy Practice, Год журнала: 2024, Номер 15(4), С. 53 - 57
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0