Sclerosis, Год журнала: 2024, Номер 2(4), С. 378 - 393
Опубликована: Дек. 5, 2024
Collagen export from the endoplasmic reticulum is required for normal tissue homeostasis, and yet, in fibrotic disorders, this process significantly upregulated. In review, we will focus on signaling cascade inflammasome how that promotes collagen via proinflammatory/profibrotic cytokines. Concordantly, these cytokines also induce expression of TANGO1 to cope with increased movement through reticulum. cells, pathway finely tuned meet necessary demand export. Currently, role disorders induces its not well understood. assimilate current information concerning activation it expression, leading fibrosis.
Язык: Английский