A review of animal models for burning mouth syndrome: Mechanistic insights and knowledge gaps
Oral Diseases,
Год журнала:
2024,
Номер
30(6), С. 3761 - 3770
Опубликована: Март 4, 2024
Abstract
Objectives
The
underlying
mechanisms
of
burning
mouth
syndrome
(BMS)
remain
unclear
leading
to
challenges
and
unsatisfactory
management.
Current
treatments
focus
primarily
on
symptom
relief,
with
few
consistently
achieving
a
50%
reduction
in
pain.
This
review
aims
explore
animal
models
BMS
gain
better
understanding
the
discuss
potential
existing
knowledge
gaps.
Methods
A
comprehensive
PubMed
®
,
Google
Scholar,
Scopus
was
performed
assess
advances
significant
gaps
rodent
that
mimic
BMS‐related
symptoms.
Results
Rodent
involve
reproduction
dry‐tongue,
chorda
tympani
transection,
or
overexpression
artemin
protein.
Existing
preclinical
tend
highlight
one
specific
etiopathogenesis
often
overlook
sex‐
hormone‐specific
factors.
Conclusion
Combining
aspects
from
various
could
prove
beneficial
developing
experimental
designs
outcomes
encompassing
multifaceted
nature
BMS.
Язык: Английский
Deleting Mitochondrial Superoxide Dismutase 2 in Salivary Gland Ductal Epithelial Cells Recapitulates Non-Sjögren’s Sicca Syndrome
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 5983 - 5983
Опубликована: Май 30, 2024
Elevated
oxidative
stress
can
play
a
pivotal
role
in
autoimmune
diseases
by
exacerbating
inflammatory
responses
and
tissue
damage.
In
Sjögren’s
disease
(SjD),
the
contribution
of
pathogenesis
remains
unclear.
To
address
this
question,
we
created
mice
with
tamoxifen-inducible
conditional
knockout
(KO)
critical
antioxidant
enzyme,
superoxide
dismutase
2
(Sod2),
salivary
glands
(i-sg-Sod2
KO
mice).
Following
tamoxifen
treatment,
Sod2
deletion
occurred
primarily
ductal
epithelium,
showed
significant
downregulation
expression.
At
twelve
weeks
post-treatment,
from
i-sg-Sod2
exhibited
increased
3-Nitrotyrosine
staining.
Bulk
RNA-seq
revealed
alterations
gene
expression
pathways
related
to
ribosome
biogenesis,
mitochondrial
function,
phosphorylation.
Significant
changes
were
noted
genes
characteristic
gland
ionocytes.
The
developed
reversible
glandular
hypofunction.
However,
functional
loss
was
not
accompanied
lymphocytic
foci
or
circulating
anti-nuclear
antibodies.
These
data
demonstrate
that
although
localized
cells
insufficient
for
SjD
development,
it
induced
dysfunction.
mouse
resembles
patients
classified
as
non-Sjögren’s
sicca
will
be
valuable
model
deciphering
oxidative-stress-mediated
dysfunction
recovery
mechanisms.
Язык: Английский
Hyposalivation in patients with psoriasis: Association with severity, inflammatory, and anti‐inflammatory cytokine biomarkers of the disease
Biotechnology and Applied Biochemistry,
Год журнала:
2024,
Номер
71(5), С. 1170 - 1180
Опубликована: Май 28, 2024
The
aim
of
the
study
is
to
expound
effect
psoriasis
on
salivary
glands
by
evaluating
secretion
saliva
and
cytokine
biomarkers
in
patients
with
psoriasis.
This
was
conducted
recruiting
120
subjects
that
included
60
diagnosed
clinically
active
healthy
controls
who
were
age
gender
matched
psoriatic
subjects.
Unstimulated
whole
collected
from
all
spitting
method,
levels
tumor
necrosis
factor-alpha
(TNF-α),
interferon-gamma
(IFN-γ),
interleukin-2
(IL-2),
IL-10
(IL-10)
determined
via
enzyme-linked
immunosorbent
assay
(BT
Lab,
Shanghai,
China).
Secretion
considerably
reduced
than
controls.
concentrations
pro-inflammatory
cytokines
(TNF-α,
IFN-γ,
IL-2)
significantly
increased,
whereas
level
anti-inflammatory
markedly
decreased
hyposalivation
compared
Our
results
demonstrated
significant
negative
correlation
flow
rates
disease
severity.
No
correlations
obtained
between
tested
our
study.
Findings
reflect
inflammation
patients.
inflammatory
responses
gland
tissues
virtue
increased
together
lower
may
have
a
role
affecting
unstimulated
decreases
severity
duration
disease.
Язык: Английский
Effect of ibuprofen on the submandibular salivary gland in rats: Histological and biochemical study
Regulatory Mechanisms in Biosystems,
Год журнала:
2024,
Номер
15(4), С. 755 - 759
Опубликована: Окт. 11, 2024
This
study
aims
to
assess
the
histological
and
biochemical
effects
of
ibuprofen
on
submandibular
salivary
gland
in
rats.
The
provides
detailed
data
ibuprofen's
impact
oxidative
stress
levels
structural
changes
gland.
A
total
15
male
rats
were
used,
divided
into
three
groups:
control
group,
left
untreated;
first
which
received
a
moderate
dose
(200
mg/kg/day);
second
higher
(400
mg/kg/day).
Ibuprofen
was
administered
orally
for
3
weeks.
results
showed
that
group
at
400
mg/kg
exhibited
apoptosis
necrosis
granular
convoluted
tubule
cells
degeneration
striated
duct
with
sloughing.
analysis
indicated
significant
increase
caspase-3
concentration
compared
(0.398
±
0.001).
Additionally,
this
high-dose
marked
decrease
antioxidant
capacity
(TAC)
(30.1
1.1)
indicating
high
negatively
affects
system’s
capacity.
In
conclusion,
doses
may
cause
damage
tissue
body's
system,
as
well
programmed
cell
death,
raising
likelihood
cellular
damage.
It
is
important
be
careful
when
taking
amounts
long
time
period
because
it
can
health
problems
related
digestive
system
risk
patients.
Therefore
using
other
treatments
alongside
might
reduce
any
tissues.
Язык: Английский