Abstract
Rheumatoid
arthritis
and
osteoarthritis,
the
most
common
forms
of
arthritis,
are
chronic,
painful,
disabling
conditions.
Although
both
diseases
differ
in
etiology,
they
manifest
progressive
joint
destruction
characterized
by
pathological
changes
articular
cartilage,
bone,
synovium.
While
potent
anti-inflammatory
properties
therapeutic
(i.e.,
exogenous)
glucocorticoids
have
been
heavily
researched
widely
used
clinical
practice,
role
endogenous
susceptibility
disease
progression
remains
poorly
understood.
Current
evidence
from
mouse
models
suggests
that
local
glucocorticoid
signaling
is
upregulated
pro-inflammatory
microenvironment
rheumatoid
aging-related
mechanisms
osteoarthritis.
Furthermore,
these
indicate
macrophages,
mast
cells,
chondrocytes
has
effects,
while
fibroblast-like
synoviocytes,
myocytes,
osteoblasts,
osteocytes
actions
arthritis.
Conversely,
osteoblasts
destructive
actions.
Together
studies
provide
insights
into
pathogenesis
inflammatory
degenerative
disease.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Июль 18, 2023
Gene-engineered
immune
cell
therapies
have
partially
transformed
cancer
treatment,
as
exemplified
by
the
use
of
chimeric
antigen
receptor
(CAR)-T
cells
in
certain
hematologic
malignancies.
However,
there
are
several
limitations
that
need
to
be
addressed
target
more
types.
Natural
killer
(NK)
a
type
innate
represent
unique
biology
surveillance.
In
particular,
NK
obtained
from
heathy
donors
can
serve
source
for
genetically
engineered
therapies.
Therefore,
NK-based
therapies,
including
cells,
CAR-NK
and
antibodies
induce
antibody-dependent
cellular
cytotoxicity
emerged.
With
recent
advances
genetic
engineering
techniques,
cell-based
become
promising
approaches
wide
range
cancers,
viral
infections,
senescence.
This
review
provides
brief
overview
characteristics
summarizes
diseases
could
benefit
addition,
we
discuss
preclinical
clinical
investigations
on
adoptive
transfer
agents
modulate
activity.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Май 24, 2023
Accumulating
clinical
evidence
indicates
extensive
inter-individual
variations
in
the
effectiveness
and
adverse
effects
of
standard
treatment
protocols,
which
are
largely
attributed
to
multifactorial
regulation
hepatic
CYP-dependent
drug
metabolism
that
is
connected
with
either
transcriptional
or
post-translational
modifications.
Age
stress
belong
most
important
factors
CYP
gene
regulation.
Alterations
neuroendocrine
responses
stress,
associated
modified
hypothalamo-pituitary-adrenal
axis
function,
usually
accompany
ageing.
In
this
light,
ageing
followed
by
a
decline
functional
integrity
organs,
including
liver,
failure
preserving
homeostasis
under
increased
morbidity
susceptibility
among
others,
holds
determinant
role
CYP-catalyzed
thus,
outcome
toxicity
pharmacotherapy.
Modifications
metabolizing
capacity
liver
age
have
been
reported
particular,
activity
main
isoforms
male
senescent
rats,
indicating
decreased
higher
levels
drug-substrates
their
blood.
These
along
restricted
experience
use
medicines
childhood
elderly,
could
explain
at
an
extent
variability
efficacy
outcomes,
underscore
necessity
designing
accordingly.
Bone Reports,
Год журнала:
2024,
Номер
20, С. 101750 - 101750
Опубликована: Март 1, 2024
Age-associated
osteoporosis
(AAOP)
poses
a
significant
health
burden,
characterized
by
increased
fracture
risk
due
to
declining
bone
mass
and
strength.
Effective
prevention
early
treatment
strategies
are
crucial
mitigate
the
disease
burden
associated
healthcare
costs.
Current
therapeutic
approaches
effectively
target
individual
contributing
factors
AAOP.
Nonetheless,
management
of
AAOP
is
complicated
multitude
variables
that
affect
its
development.
Main
intrinsic
extrinsic
reviewed
here,
including
mechanical
unloading,
nutrient
deficiency,
hormonal
disbalance,
disrupted
metabolism,
cognitive
decline,
inflammation
circadian
disruption.
Furthermore,
it
discussed
how
these
can
be
targeted
for
treatment.
Although
valuable
as
targets
intervention,
interconnectedness
result
in
unique
etiology
every
patient.
Acknowledgement
multifaceted
nature
will
enable
development
more
effective
sustainable
strategies,
based
on
holistic,
patient-centered
approach.
Diseases,
Год журнала:
2025,
Номер
13(2), С. 42 - 42
Опубликована: Фев. 1, 2025
Obesity,
chronic
pain,
and
aging
are
prevalent
global
challenges
with
profound
implications
for
health
well-being.
Central
to
these
processes
adrenal
hormones,
particularly
cortisol
dehydroepiandrosterone
(DHEA),
along
its
sulfated
form
(DHEAS).
Cortisol,
essential
stress
adaptation,
can
have
adverse
effects
on
pain
perception
when
dysregulated,
while
DHEA/S
possess
properties
that
may
mitigate
effects.
This
review
explores
the
roles
of
in
contexts
obesity,
acute
aging,
age-related
diseases.
We
examine
hormonal
balance,
specifically
cortisol-to-DHEA
ratio
(CDR),
as
a
key
marker
system
functionality
impact
sensitivity,
neurodegeneration,
physical
decline.
Elevated
CDR
decreased
levels
associated
worsened
outcomes,
including
increased
frailty,
immune
dysfunction,
progression
conditions
such
osteoporosis
Alzheimer’s
disease.
synthesizes
current
literature
highlight
complex
interplay
between
hormones
their
broader
health.
It
aims
provide
insights
into
potential
future
therapies
improve
management
promote
healthy
weight
aging.
By
investigating
mechanisms,
this
work
contributes
deeper
understanding
physiological
intersections
endocrine
system.
Journal of Clinical Medicine,
Год журнала:
2019,
Номер
8(10), С. 1564 - 1564
Опубликована: Окт. 1, 2019
Introduction:
Osteoporosis
is
increasingly
prevalent
in
the
elderly,
with
fractures
mostly
occurring
women
and
men
who
are
older
than
55
65
years
of
age,
respectively.
The
aim
this
review
was
to
examine
evidence
regarding
influence
hormones
on
bone
metabolism,
followed
by
clinical
data
hormonal
changes
attempt
provide
possible
poorly
explored
diagnostic
therapeutic
candidate
targets
for
management
primary
osteoporosis
aging
population.
Material
methods:
An
extensive
Medline
search
using
PubMed,
Embase,
Cochrane
Library
performed.
Results:
While
rise
Thyroid-stimulating
hormone
(TSH)
levels
has
a
protective
role
mass,
decline
estrogen,
testosterone,
Insulin-like
growth
factor
1
(IGF1),
vitamin
D
cortisol,
parathyroid
hormone,
follicle-stimulating
(FSH)
favor
loss
elderly.
Particularly,
AA
rs6166
FSH
receptor
(FSHR)
genotype,
encoding
more
sensitive
FSHR
that
encoded
GG
one,
associated
low
total
body
mass
density
(BMD),
independently
circulating
estrogen.
A
polyclonal
antibody
FSHR-binding
sequence
against
β-subunit
murine
seems
be
effective
ameliorating
ovariectomized
mice.
Conclusions:
complete
assessment
should
completed
both
during
evaluation.
Novel
tools
might
developed
male
female
osteoporosis.
Abstract
Background
The
Ecuadorian
earthquake
in
April
16th
was
the
second
strongest
and
deadliest
2016
worldwide,
with
approximately
one
million
people
affected.
In
this
paper,
we
analyzed
psychological
impact
relationship
between
mental
health
events
various
earthquake-related
stressors
related
to
earthquake,
9
months
after
event.
Methods
We
conducted
an
analytical
cross-sectional
study,
applying
anonymous
survey
316
adolescents
(13–19
years
old)
from
Muisne,
Ecuador.
Suicidal
tendency,
depression,
anxiety
post-traumatic
stress
(PTSD)
were
evaluated
via
Child
PTSD
Symptom
Scale
(CPSS),
Spence
Children’s
Anxiety
,
Okasha
Suicidality
Center
for
Epidemiologic
Studies
Depression
(CES-D)
adapted
seven-questions
survey.
Results
found
a
high
prevalence
of
suicidal
ideations
behavior,
posttraumatic
stress,
depression
compared
international
studies.
Even
though
currently
living
shelters
had
higher
levels
anxiety,
their
tendency
significantly
lower
than
those
own
or
relatives’
home.
Finally,
not
associated
suicidality
events,
exception
economic
damage
suffered
by
family.
Conclusions
High
among
high-school
students
found,
especially
who
have
serious
damage.
families
unemployment
rates
parents
seems
be
lack
hope
favorable
perspectives
future,
situation
that
might
lead
emotional
disturbances
disorders.
Although
prolonged
homelessness
experience
may
stressful
occurrence,
also
spiritual
growth
adolescents,
work
as
protective
factor
against
attempts.
