Maturation of beta cells: lessons from in vivo and in vitro models
Diabetologia,
Год журнала:
2022,
Номер
65(6), С. 917 - 930
Опубликована: Март 4, 2022
Abstract
The
ability
to
maintain
normoglycaemia,
through
glucose-sensitive
insulin
release,
is
a
key
aspect
of
postnatal
beta
cell
function.
However,
terminally
differentiated
identity
does
not
necessarily
imply
functional
maturity.
Beta
maturation
therefore
continuation
development,
albeit
process
that
occurs
postnatally
in
mammals.
Although
many
important
features
have
been
identified
the
study
maturation,
as
yet
no
unified
mechanistic
model
maturity
exists.
Here,
we
review
recent
findings
about
underlying
mechanisms
maturation.
These
include
systemic
hormonal
and
nutritional
triggers
operate
energy-sensing
machinery
shifts
within
cells,
resulting
primed
metabolic
states
allow
for
appropriate
glucose
trafficking
and,
ultimately,
release.
We
also
draw
attention
expansive
synergistic
nature
these
pathways
emphasise
dependent
on
overlapping
regulatory
networks.
Graphical
abstract
Язык: Английский
miR-92a-3p and miR-182-3p as potential biomarkers for the differential diagnosis of gestational diabetes mellitus and its correlation with pregnancy outcomes
Irish Journal of Medical Science (1971 -),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Язык: Английский
Mechanisms Underlying the Expansion and Functional Maturation of β-Cells in Newborns: Impact of the Nutritional Environment
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(4), С. 2096 - 2096
Опубликована: Фев. 14, 2022
The
functional
maturation
of
insulin-secreting
β-cells
is
initiated
before
birth
and
completed
in
early
postnatal
life.
This
process
has
a
critical
impact
on
the
acquisition
an
adequate
β-cell
mass
capacity
to
meet
adapt
insulin
needs
later
Many
cellular
pathways
playing
role
development
have
already
been
identified.
However,
single-cell
transcriptomic
proteomic
analyses
continue
reveal
new
players
contributing
identity.
In
this
review,
we
provide
updated
picture
mechanisms
governing
expansion
transition
cells
from
immature
mature
state.
We
then
highlight
contribution
environment
discuss
adverse
utero
neonatal
characterized
by
calorie
fat
overload
or
protein
deficiency
undernutrition.
Inappropriate
nutrition
life
constitutes
risk
factor
for
developing
diabetes
adulthood
can
affect
offspring
over
two
generations.
A
better
understanding
these
events
occurring
period
will
help
strategies
produce
design
novel
therapeutic
approaches
prevention
treatment
diabetes.
Язык: Английский
Effects of Phytochemicals on Type 2 Diabetes via MicroRNAs
Current Nutrition Reports,
Год журнала:
2024,
Номер
13(3), С. 444 - 454
Опубликована: Май 28, 2024
Abstract
Purpose
of
Review
Type
2
diabetes,
characterized
by
inadequate
insulin
secretion
and
resistance,
is
increasingly
prevalent.
To
effectively
manage
type
identifying
new
therapeutic
targets
crucial.
MicroRNAs,
short
noncoding
RNA
molecules,
play
a
pivotal
role
in
regulating
β-cell
function,
production,
show
promise
as
biomarkers
for
predicting
diabetes
onset.
Phytochemicals,
known
their
antioxidant
activities,
may
influence
microRNA
expression,
potentially
improving
sensitivity
mitigating
associated
complications.
This
review
aims
to
explore
the
significance
potential
biomarkers,
how
certain
phytochemicals
modulate
expressions
reduce
or
prevent
its
Recent
Findings
Current
research
suggests
that
microRNAs
novel
diagnosing
monitoring
diabetic
Additionally,
regulate
control
presenting
strategy.
Summary
The
multifactorial
effects
on
complications
through
warrant
further
elucidate
mechanisms.
Comprehensive
clinical
trials
are
needed
assess
safety
efficacy
combinations.
Given
ability
incorporating
phytochemical-rich
foods
into
diet
be
beneficial.
Язык: Английский
Unraveling diabetes complexity through natural products, miRNAs modulation, and future paradigms in precision medicine and global health
Clinical Nutrition ESPEN,
Год журнала:
2024,
Номер
63, С. 283 - 293
Опубликована: Июль 1, 2024
Язык: Английский
Liver kinase B1 (LKB1) regulates the epigenetic landscape of mouse pancreatic beta cells
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 15, 2024
Liver
kinase
B1
(LKB1/STK11)
is
an
important
regulator
of
pancreatic
β-cell
identity
and
function.
Elimination
Язык: Английский
Liver kinase B1 (LKB1) regulates the epigenetic landscape of mouse pancreatic beta cells
The FASEB Journal,
Год журнала:
2024,
Номер
38(16)
Опубликована: Авг. 14, 2024
Liver
kinase
B1
(LKB1/STK11)
is
an
important
regulator
of
pancreatic
β-cell
identity
and
function.
Elimination
Lkb1
from
the
results
in
improved
glucose-stimulated
insulin
secretion
accompanied
by
profound
changes
gene
expression,
including
upregulation
several
neuronal
genes.
The
mechanisms
through
which
LKB1
controls
expression
are,
at
present,
poorly
understood.
Here,
we
explore
impact
β
cell-selective
deletion
on
chromatin
accessibility
mouse
islets.
To
characterize
role
regulation
transcriptional
level,
combine
these
data
with
a
map
islet
active
transcription
start
sites
histone
marks.
We
demonstrate
that
elimination
β-cells
widespread
accessibility,
correlating
transcript
levels.
Changes
occurred
hundreds
promoter
enhancer
regions,
many
were
close
to
reveal
dysregulated
enhancers
are
enriched
binding
motifs
for
factors
(TFs)
identity,
such
as
FOXA,
MAFA
or
RFX6,
identify
microRNAs
(miRNAs)
regulated
level.
Overall,
our
study
provides
new
insights
into
epigenetic
regulates
Язык: Английский