Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 14, 2025
Background
The
advanced
lung
cancer
inflammation
index
(ALI)
is
a
composite
that
combines
and
nutritional
status,
non-alcoholic
fatty
liver
disease
(NAFLD)
associated
with
inflammation,
obesity.
This
study
aimed
to
investigate
the
possible
relationship
between
ALI
NAFLD.
Methods
We
extracted
cohort
datasets
from
2017–2020
National
Health
Nutrition
Examination
Survey
(NHANES)
for
study.
Weighted
analyses
multivariate
linear
regression
models
were
applied
assess
association
Fitted
curves
threshold
effects
used
characterize
nonlinear
relationships.
Results
A
total
of
6,595
adults
aged
18–80
years
included
in
this
In
analysis,
there
was
significant
positive
NAFLD
[OR:
1.02,
95%
CI
(1.01,
1.02)].
subgroup
analyses,
maintained
females
1.02)]
not
males.
addition,
we
found
nonlinear,
an
L-shaped
inflection
point
32.47.
showed
U-shaped
male
population,
40.65,
female
30.61.
Conclusion
Our
suggests
high
levels
prevalence
US
adult
population.
However,
more
clinical
studies
are
needed
confirm
finding.
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Март 26, 2025
The
aim
of
this
study
was
to
investigate
the
relationship
between
visceral
adiposity
index
(VAI)
and
lipid
accumulation
products
(LAP)
frailty
(FI)
in
older
Americans.
Based
on
data
from
2007–2018
National
Health
Nutrition
Examination
Survey
(NHANES),
population
consisted
3,396
adults
aged
60
years
with
a
mean
age
69.48
±
6.76
years.
findings
weighted
multivariate
regression
analysis
demonstrated
strong
correlation
prevalence
greater
VAI
LAP.
In
fully
adjusted
model,
association
remained
significant,
an
OR
1.49
(95%
CI:
1.26,
1.77;
p
<
0.0001.)
LAP
also
1.88
1.55,
2.29;
0.0001).
Further
nonlinear
analyses
by
generalized
additive
modeling
(GAM)
revealed
significant
relationships
frailty,
effects
were
more
pronounced
female
population.
Subgroup
showed
that
positive
correlations
across
populations
there
no
interaction
most
subgroups.
addition,
sensitivity
validated
robustness
these
results,
further
confirming
conclusion
as
independent
risk
factors
for
frailty.
Finally,
ROC
outperformed
predicting
suggesting
potential
early
screening
Overall,
are
elderly
have
important
clinical
applications.
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Март 28, 2025
This
study
examines
the
link
between
serum
manganese
(Mn)
levels
and
non-alcoholic
fatty
liver
disease
(NAFLD),
with
a
focus
on
gender
differences.
Utilizing
data
from
NHANES
2017-2018,
we
included
participants
aged
18
older,
excluding
those
without
ultrasonic
assessment,
Mn
data,
or
hepatitis
significant
alcohol
use.
The
final
analysis
comprised
4,294
individuals,
2,708
in
NAFLD
group
1,586
non-NAFLD
group.
Serum
was
quantified
via
inductively
coupled
plasma
mass
spectrometry.
We
compared
demographic
health-related
variables
groups
using
appropriate
statistical
tests
categorized
into
quartiles
based
levels.
Multivariate
logistic
regression
spline
analyses
were
conducted
to
evaluate
association
risk
by
gender.
significantly
elevated
individuals
(9.06
vs.
9.33
μg/L,
Z
=
2.815,
p
0.005).
After
adjustments,
males
third
quartile
showed
higher
(OR
1.575;
95%
CI:
1.193-2.087),
while
females
fourth
also
had
increased
1.725;
1.313-2.269),
both
first
(p
<
0.01).
A
positive
dose-response
relationship
found
for
genders
(P
trend
<0.01),
nonlinear
associations
nonlinearity
<0.01)
linear
0.818).
Significant
interactions
ethnicity
hypertension
noted.
Higher
are
associated
genders,
highlighting
need
gender-specific
considerations
future
studies
clinical
practices.
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
16
Опубликована: Март 31, 2025
Background
Chronic
kidney
disease
(CKD)
has
become
a
significant
global
public
health
challenge,
which
was
reported
to
be
highly
correlated
with
the
triglyceride
glucose-body
mass
index
(TyG-BMI).
Nevertheless,
literature
exploring
association
between
changes
in
TyG-BMI
and
CKD
incidence
is
scant,
most
studies
focusing
on
individual
values
of
TyG-BMI.
We
aimed
investigate
whether
cumulative
average
were
associated
incidence.
Methods
Data
our
study
obtained
from
China
Health
Retirement
Longitudinal
Study
(CHARLS),
an
ongoing
nationally
representative
prospective
cohort
study.
The
exposure
2011
2015.
calculated
by
formula
ln
[TG
(mg/dl)
×
FBG
(mg/dl)/2]
BMI
(kg/m
2
),
as
follows:
(TyG-BMI
+
2015
)/2.
Logistic
regressions
used
determine
different
quartiles
Meanwhile,
restricted
cubic
spline
applied
examine
potential
nonlinear
In
addition,
subgroup
analysis
test
robustness
results.
Results
Of
6117
participants
(mean
[SD]
age
at
baseline,
58.64
[8.61]
years),
2793
(45.7%)
men.
During
4
years
follow-up,
470
(7.7%)
incident
cases
identified.
After
adjusting
for
confounders,
compared
lowest
quartile
TyG-BMI,
3rd
4th
had
higher
risk
onset.
ORs
95%CIs
[1.509(1.147,
1.990)]
[1.452(1.085,
1.948)]
respectively.
showed
liner
(
p
-nonlinear
=
0.139).
Conclusions
independently
middle-aged
older
adults.
Monitoring
long-term
may
assist
early
identification
individuals
high
CKD.
BMC Gastroenterology,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 4, 2025
The
incidence
of
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
among
individuals
with
hyperuricemia
is
significantly
high.
aim
this
study
was
to
identify
effective
biomarkers
for
the
detection
MASLD
patients
hyperuricemia.
We
conducted
an
analysis
involving
3424
participants
from
National
Health
and
Nutrition
Examination
Survey
(1999-2020).
To
potential
significant
variables,
we
employed
Boruta's
algorithm,
SHapley
Additive
exPlanations
(SHAP)
random
forests.
Multivariable
logistic
regression
models
were
utilized
assess
odds
ratio
(OR)
developing
MASLD.
evaluate
accuracy
clinical
value
our
prediction
model,
receiver
operating
characteristic
(ROC)
curves
decision
curve
(DCA)
curves.
Among
population
(mean
[SD]
age,
54
[20]
years,
1788
[52.22%]
males)
hyperuricemia,
1670
had
Using
SHAP
forests,
suggested
that
Triglyceride
Glucose-Waist
Circumference
(TyG_WC)
one
most
variables
in
predicting
risk,
area
under
(AUROC)
0.865.
restricted
spline
(RCS)
revealed
a
positive
association
between
TyG_WC
MASLD,
when
compared
lowest
quantile
TyG_WC,
risk
highest
137.96
times
higher.
predictive
strategy
incorporating
notably
enhanced
threshold
probabilities
spanning
approximately
0%
100%,
resulting
improvement
net
benefit.
Our
found
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 14, 2025
Background
The
advanced
lung
cancer
inflammation
index
(ALI)
is
a
composite
that
combines
and
nutritional
status,
non-alcoholic
fatty
liver
disease
(NAFLD)
associated
with
inflammation,
obesity.
This
study
aimed
to
investigate
the
possible
relationship
between
ALI
NAFLD.
Methods
We
extracted
cohort
datasets
from
2017–2020
National
Health
Nutrition
Examination
Survey
(NHANES)
for
study.
Weighted
analyses
multivariate
linear
regression
models
were
applied
assess
association
Fitted
curves
threshold
effects
used
characterize
nonlinear
relationships.
Results
A
total
of
6,595
adults
aged
18–80
years
included
in
this
In
analysis,
there
was
significant
positive
NAFLD
[OR:
1.02,
95%
CI
(1.01,
1.02)].
subgroup
analyses,
maintained
females
1.02)]
not
males.
addition,
we
found
nonlinear,
an
L-shaped
inflection
point
32.47.
showed
U-shaped
male
population,
40.65,
female
30.61.
Conclusion
Our
suggests
high
levels
prevalence
US
adult
population.
However,
more
clinical
studies
are
needed
confirm
finding.
