Advancements in Genetic Biomarkers and Exogenous Antioxidant Supplementation for Safeguarding Mammalian Cells against Heat-Induced Oxidative Stress and Apoptosis

Antioxidants, Год журнала: 2024, Номер 13(3), С. 258 - 258

Опубликована: Фев. 20, 2024

Heat stress represents a pervasive global concern with far-reaching implications for the reproductive efficiency of both animal and human populations. An extensive body published research on heat effects utilizes controlled experimental environments to expose cells tissues its disruptive influence physiological aspects phenotypic traits, encompassing parameters such as sperm quality, motility, viability, overall competence. Beyond these immediate effects, has been linked embryo losses, compromised oocyte development, even infertility across diverse species. One primary mechanisms underlying adverse outcomes is elevation reactive oxygen species (ROS) levels precipitating oxidative apoptosis within mammalian cells. Oxidative are recognized pivotal biological factors through which exerts impact male female In concerted effort mitigate detrimental consequences stress, supplementation antioxidants, in natural synthetic forms, explored potential intervention strategy. Furthermore, possess inherent self-protective that come into play during episodes aiding their survival. This comprehensive review delves multifaceted traits elucidates intricate molecular underpinning cells, compromise normal function. Additionally, we provide succinct overview antioxidant interventions highlight genetic biomarkers capabilities, collectively offering promising avenues ameliorating negative by restraining stress.

Язык: Английский

---

Increased late preterm birth risk and altered uterine blood flow upon exposure to heat stress

EBioMedicine, Год журнала: 2023, Номер 93, С. 104651 - 104651

Опубликована: Июнь 22, 2023

Climate change, in particular the exposure to heat, impacts on human health and can trigger diseases. Pregnant people are considered a vulnerable group given physiological changes during pregnancy potentially long-lasting consequences for offspring. Evidence published date higher risk of complications upon heat stress from geographical areas with high ambient temperatures. Studies geographic regions temperate climates sparse; however, these critical since individuals may be less equipped adapt stress. This study addresses significant gap knowledge due temperature increase documented globally.Birth data singleton pregnancies (n = 42,905) tertiary care centre Hamburg, Germany, between 1999 2021 were retrospectively obtained matched climate warmer season (March September) provided by adjacent federal meteorological station German National Meteorological Service calculate relative heat-associated preterm birth. Heat events defined ascending percentiles combination humidity over periods up 5 days. Further, ultrasound longitudinal prospective cohort 612) 2012 used identify pathophysiological causes heat-induced birth.Both extreme prolonged increased birth (RR: 1.59; 95% CI: 1.01-2.43; p 0.045; RR: 1.20; 1.02-1.40; 0.025). We identified period gestational ages 34-37 weeks that resulted late 1.67; 1.14-1.43; 0.009). Pregnancies female fetus more prone stress-associated found was associated altered vascular resistance within uterine artery.Heat caused temperatures increases region climate. Prenatal routine should revised such provide active surveillance women at risk.Found acknowledgements.

Язык: Английский

---

Factors Associated with the Development of Depression and the Influence of Obesity on Depressive Disorders: A Narrative Review

Biomedicines, Год журнала: 2024, Номер 12(9), С. 1994 - 1994

Опубликована: Сен. 2, 2024

Depression affects several aspects of life, including socioeconomic status, relationships, behavior, emotions, and overall health. The etiology depression is complex influenced by various factors, with obesity emerging as a significant contributor. This narrative review aims to investigate the factors associated development depression, particular focus on role obesity. literature search was conducted PubMed, Embase, PsycINFO from May July 2024. highlights impact environmental conditions; lifestyle choices, physical activity dietary habits; stress; traumatic experiences; neurotransmitter imbalances; medical psychological hormone fluctuations; epigenetic depression. A key emphasis placed inflammatory processes linked obesity, which may drive bidirectional relationship between findings suggest that an increased risk potentially due chronic inflammation, neurochemical dysregulation, emotional social challenges related weight stigma management. Understanding these interconnected important for developing targeted interventions address both leading improved quality life those affected.

Язык: Английский

---

The Impact of Climate Change on Immunity and Gut Microbiota in the Development of Disease

Diseases, Год журнала: 2024, Номер 12(6), С. 118 - 118

Опубликована: Июнь 3, 2024

According to the definition provided by United Nations, “climate change” describes persistent alterations in temperatures and weather trends. These may arise naturally, such as fluctuations solar cycle. Nonetheless, since 19th century, human activities have emerged primary agent for climate change, primarily attributed combustion of fossil fuels coal, oil, gas. Climate change can potentially influence well-being, agricultural production, housing, safety, employment opportunities all individuals. The immune system is an important interface through which global affects health. Extreme heat, events environmental pollutants could impair both innate adaptive responses, promoting inflammation genomic instability, increasing risk autoimmune chronic inflammatory diseases. Moreover, has impact on soil gut microbiome composition, further explain changes health outcomes. This narrative review aims explore disease, focusing specifically its effects microbiota. Understanding how these factors contribute development physical mental illness allow design strategies aimed at reducing negative pollution

Язык: Английский

---

Scoping Review of Climate Drivers on Maternal Health:Current Evidence and Clinical Implications

AJOG Global Reports, Год журнала: 2025, Номер 5(1), С. 100444 - 100444

Опубликована: Янв. 18, 2025

To systematically review the literature on associations between climate drivers and health outcomes among pregnant people. This fills a gap by synthesizing evidence for clinician audience. Systematic scoping of articles published in PubMed clinicaltrials.gov from January 2010 through December 2023. Empirical studies English-language peer-reviewed journals, assessing select adverse maternal birth outcomes. The included examining heat, storms, sea level rise, flooding, drought, wildfires, other climate-related factors. Health preterm birth, low birthweight, small gestational age, diabetes, pre-eclampsia/eclampsia, miscarriage/stillbirth mortality. protocol was registered with International Platform Registered Review Meta-analysis Protocols (INPLASY202410004, 3, 2024) conducted accordance Preferred Reporting Items Reviews Meta-Analysis (PRISMA). Data were extracted 2 authors; quality risk bias assessed independently. Total 966 references screened; 16.35% (k=158) met inclusion criteria. majority (146/158; 92.4%) documented statistically significant clinically meaningful perinatal outcomes, including stillbirth as well preeclampsia, miscarriage, death. Among most durable findings: extreme heat exposure early late pregnancy associated increased stillbirth. Driven part large (often population-based) objective surveillance data or medical record reviews, this evaluated high (scoring 7-9 Newcastle-Ottawa Scale). Risk generally low. Climate are consistently Continuing education clinicians, clinician-patient communications should be expanded to address risks change weather exposure, especially late-pregnancy. Results inform multilevel interventions effects during practice advisories, protocols, checklists, clinical guidelines obstetrics.

Язык: Английский

---

Erste Schritte zu mehr Klimaschutz und Nachhaltigkeit in der gynäkologischen Praxis

Die Gynäkologie, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

---

Eco-anxiety and Climate Anxiety: Bellwethers of the Climate Crisis's Mental Health Impact on Children and Adolescents

Journal of Developmental & Behavioral Pediatrics, Год журнала: 2025, Номер 46(2), С. e223 - e226

Опубликована: Фев. 10, 2025

ABSTRACT Objective: To highlight the need for more research about climate change's effects on child and adolescent mental health. Method: Articles reports were searched in 12 pediatric journals 10 international societies using mesh terms “climate change health,” children's “eco-anxiety.” scanned relevancy change,” crisis,” “mental “child,” “anxiety,” anxiety.” Relevant literature was compiled analyzed. Results: Although crisis has been highlighted as a critical threat to physical health of adolescents worldwide, its impacts are far less recognized. Existing is limited, primarily focusing acute response adults directly affected by extreme weather events rather than emerging indirect effects. Far limited children, who hypothesized bear brunt detriment change. In addition, nonstandardized scales definitions lack nationally representative data, among many other things, hinder current understanding, attention, evidence-based action prevent treat these Conclusion: Gathering information regarding paramount. Consequently, development workforce, funding stream, standardized methodology necessary properly investigate aid children facing crisis's

Язык: Английский

---

Akademisierung des Hebammenberufes: Erweiterte Arbeitsfelder und neue Rollen

Zeitschrift für Geburtshilfe und Neonatologie, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Zusammenfassung Seit 2020 ist der Hebammenberuf in Deutschland vollständig akademisiert. Das praxisintegrierende Bachelorstudium bereitet Hebammen umfassend auf die Betreuung von Schwangeren, Gebärenden und Neugeborenen vor. Diese Reform, empfohlen vom Wissenschaftsrat, stärkt Rolle Hebamme im modernen Gesundheitssystem passt sie an wachsenden Herausforderungen an. Neben Primärqualifikation gewinnt Einführung hebammenspezifischen Masterstudiengängen Bedeutung. Programme bereiten spezialisierte Aufgaben vor, wie Versorgung vulnerabler Bevölkerungsgruppen. Im Rahmen können Kompetenzen des Advanced Midwifery Practice (AMP) erworben werden. Dieses befähigt Absolvent/-innen, komplexe Situationen effektiv zu meistern, kontinuierliche, evidenzbasierte leisten soziale Ungleichheiten Gesundheitsversorgung verringern. Vorliegender Artikel skizziert welches Potenzial hierin für Verbesserung Versorgungsqualität Frauen ihren Familien liegt welche strukturellen Veränderungen dafür angestoßen werden sollten.

---

Sex‐specific effects of environmental temperature during gestation on fluctuating asymmetry in deciduous teeth

American Journal of Physical Anthropology, Год журнала: 2024, Номер 184(4)

Опубликована: Апрель 16, 2024

External environmental heat exposure during gestation impacts the physiology of human development in utero, but evidence for these has not yet been explored dentition. We examined deciduous teeth fluctuating asymmetry (FA), a measure developmental instability, together with gestational temperature data drawn from historical weather statistics.

Язык: Английский

---

Association of Psychiatric Emergency Visits and Warm Ambient Temperature during Pregnancy: A Time-Stratified Case-Crossover Study

Environmental Health Perspectives, Год журнала: 2024, Номер 132(6)

Опубликована: Июнь 1, 2024

Acute exposure to high ambient temperature and heat waves during the warm season has been linked with psychiatric disorders. Emerging research shown that pregnant people, due physiological psychological changes, may be more sensitive extreme heat, acute increased risk of pregnancy complications; however, few studies have examined complications.

Язык: Английский

---