Potential application of Klotho as a prognostic biomarker for patients with diabetic kidney disease: a meta-analysis of clinical studies DOI Creative Commons

Li Xia Yu,

Min Sha,

Yue Chen

и другие.

Therapeutic Advances in Chronic Disease, Год журнала: 2023, Номер 14

Опубликована: Янв. 1, 2023

Background: Diabetic kidney disease (DKD) is a serious diabetic complication and the performance of serum Klotho in DKD’s prognostic evaluation controversial. Objective: To assess association with adverse non-kidney clinical outcomes patients DKD. Design: Clinical studies regarding relationship DKD were included. Study quality was assessed using Newcastle–Ottawa scale. Subgroup sensitive analyses performed to search for source heterogeneity. Data sources methods: We comprehensively searched PubMed, Embase, Web Science, Cochrane library databases up 27 September 2022. The associations albuminuria, such as urinary albumin creatinine ratio (UACR), persistent estimated glomerular filtration rate decline, retinopathy, cardiovascular morbidity, mortality, evaluated. indicators, correlation coefficient ( r), odds (OR), relative risk, hazard ratio, retrieved or calculated from eligible studies. Results: In all, 17 involving 5682 participants fulfilled inclusion criteria included this meta-analysis. There no significant UACR [summary r, −0.28 (−0.55, 0.04)] high By contrast, strong observed [pooled OR, 1.60 (1.15, 2.23)], 2.78 (2.11, 3.66)], combined 1.96 (1.45, 2.65)] moderate analysis indicated that age, study design, may be Conclusion: A decreased level possibly associated an increased risk developing patients; thus, possible biomarker predict outcomes. Additional are needed clarify validate Klotho’s value.

Язык: Английский

Mechanisms, Biomarkers, and Treatment Approaches for Diabetic Kidney Disease: Current Insights and Future Perspectives DOI Open Access
Jean Paule Joumaa,

Angela Raffoul,

Claudia Sarkis

и другие.

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(3), С. 727 - 727

Опубликована: Янв. 23, 2025

Diabetic Kidney Disease (DKD) is the leading cause of end-stage renal disease (ESRD) worldwide. Among individuals with type 1 diabetes mellitus (T1DM), 30–40% are at risk developing DKD. This review focuses on mechanistic processes, available and emerging biomarkers for diagnosing, monitoring, preventing DKD, as well treatment options targeted DKD patients. A literature search was conducted PubMed Scopus using specific keywords. Inclusion exclusion criteria were applied to select articles used this review. The highlights various mechanisms involved in progression more severe stages. Additionally, several have been identified, which aid diagnosing monitoring disease. Furthermore, numerous approaches being explored address underlying causes Advanced research exploring new medications remission; sodium-glucose cotransport (SGLT2) inhibitors finerenone, particular, gaining attention their novel renoprotective effects. a major complication diabetes, marked by complex multifactorial mechanisms. Thus, understanding these processes essential therapies potentially reverse progression. Biomarkers show promise early diagnosis progression, while current strategies underscore importance multifaceted approach.

Язык: Английский

Процитировано

2
Anti-Inflammatory Role of the Klotho Protein and Relevance to Aging DOI Creative Commons
Gérald J. Prud’homme, Qinghua Wang

Cells, Год журнала: 2024, Номер 13(17), С. 1413 - 1413

Опубликована: Авг. 24, 2024

The α-Klotho protein (hereafter Klotho) is an obligate coreceptor for fibroblast growth factor 23 (FGF23). It produced in the kidneys, brain and other sites. Klotho insufficiency causes hyperphosphatemia anomalies. Importantly, it associated with chronic pathologies (often age-related) that have inflammatory component. This includes atherosclerosis, diabetes Alzheimer's disease. Its mode of action these diseases not well understood, but inhibits or regulates multiple major pathways. has a membrane form soluble (s-Klotho). Cytosolic postulated characterized. s-Klotho endocrine properties are incompletely elucidated. binds to FGF receptor 1c (FGFR1c) widely expressed (including endothelial cells). also attaches FGF23, FGF23/Klotho FGFRs. Thus, might be roaming FGF23 coreceptor, functions. Notably, (cell-bound soluble) counteracts inflammation appears mitigate related aging (inflammaging). NF-κB NLRP3 inflammasome. inflammasome requires priming by produces active IL-1β, pores cell death (pyroptosis). In accord, countered injury induced toxins, damage-associated molecular patterns (DAMPs), cytokines, reactive oxygen species (ROS). blocks TGF-β Wnt ligands, which lessens fibrotic Low loss muscle mass (sarcopenia), as occurs diseases. counters inhibitory effects myostatin on muscle, reduces inflammation, improves repair following injury. inhibition factors may protective diabetic retinopathy age-related macular degeneration (AMD). review examines functions especially potential applications.

Язык: Английский

Процитировано

8
Relationship between uric acid to high-density cholesterol ratio (UHR) and circulating α-klotho: evidence from NHANES 2007–2016 DOI Creative Commons
Xuanchun Huang,

Lanshuo Hu,

Shiyi Tao

и другие.

Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)

Опубликована: Авг. 9, 2024

To investigate the relationship between uric acid to high-density lipoprotein cholesterol ratio (UHR) and circulating α-klotho levels in U.S. adults.

Язык: Английский

Процитировано

7
Vitamin D inhibits ferroptosis and mitigates the kidney injury of prediabetic mice by activating the Klotho/p53 signaling pathway DOI
Hao Chen,

Yujing Zhang,

Yufan Miao

и другие.

APOPTOSIS, Год журнала: 2024, Номер 29(9-10), С. 1780 - 1792

Опубликована: Апрель 1, 2024

Язык: Английский

Процитировано

5
Global research hotspots and trends in oxidative stress-related diabetic nephropathy: a bibliometric study DOI Creative Commons
Xiaorong Wang,

Wu Zeng,

Tingchao He

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 15

Опубликована: Янв. 10, 2025

Oxidative stress is widely acknowledged as a key pathogenic mechanism in diabetic nephropathy (DN). In recent years, the role of oxidative DN has garnered increasing attention. However, no bibliometric analysis yet been conducted on relationship between and DN. This study aims to systematically analyze relevant literature, identify trends research, assess current hotspots, predict future directions. We retrieved literature related from Web Science Core Collection database. analyzed data publication volume, countries/regions, institutions, journals, keywords, other metrics using VOSviewer, Bibliometrix R package, CiteSpace. From 2014 2024, total 4076 publications were published across 755 showing consistent upward trend each year. China United States are leading contributors this field demonstrate close collaborative efforts. The top by country, institution, journal, author include: (1919 publications), Jilin University Central South (69 each), BIOMEDICINE & PHARMACOTHERAPY (117 Prof. Sun Lin (33 publications). most frequent keyword "oxidative stress" (3683 occurrences). co-citation analysis, Alicic RZ's 2017 was cited (144 citations). These findings highlight critical importance investigating pathogenesis perspective. demonstrates steady increase research since 2014, highlighting its central Future should focus molecular mechanisms explore therapeutic potential, provide new strategies for prevention treatment

Язык: Английский

Процитировано

0
Molecular Mechanisms of Neuroprotection: The Interplay of Klotho, SIRT-1, Nrf2, and HO-1 in Neurological Health DOI

R.S. Rana,

R Mukherjee,

Sidharth Mehan

и другие.

Behavioural Brain Research, Год журнала: 2025, Номер unknown, С. 115545 - 115545

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Klotho antiaging protein: molecular mechanisms and therapeutic potential in diseases DOI Creative Commons

Aditya Dipakrao Hajare,

Neha Dagar, Anil Bhanudas Gaikwad

и другие.

Molecular Biomedicine, Год журнала: 2025, Номер 6(1)

Опубликована: Март 22, 2025

Abstract Klotho, initially introduced as an anti-aging protein, is expressed in the brain, pancreas, and most prominently kidney. The two forms of Klotho (membrane-bound soluble form) have diverse pharmacological functions such anti-inflammatory, anti-oxidative, anti-fibrotic, tumour-suppressive etc. membrane-bound form plays a pivotal role maintaining kidney homeostasis by regulating fibroblast growth factor 23 (FGF 23) signalling, vitamin D metabolism phosphate balance. deficiency has been linked with significantly reduced protection against various pathological phenotypes, including diabetic disease (DKD), which major cause chronic leading to end-stage disease. Owing pleiotropic actions klotho, it shown beneficial effects DKD tackling complex pathophysiology reducing inflammation, oxidative stress, well fibrosis. Moreover, protective effect klotho extends beyond other conditions, cardiovascular diseases, alzheimer's disease, cancer, inflammatory bowel liver Therefore, this review summarizes relationship between expression diseases special emphasis on DKD, distinct mechanisms potential exogenous supplementation therapeutic strategy. Future research into could unravel novel treatment avenues for diseases.

Язык: Английский

Процитировано

0
Association of serum Klotho and fibroblast growth factor-23 levels with vascular calcification severity in patients with chronic kidney disease: an observational cohort study DOI Creative Commons
Ping Peng, Wei Lü

International Urology and Nephrology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Metformin inhibits subretinal fibrosis by activating Klotho by miR-126-5p DOI

Zhijuan Hua,

Qin Zhu,

Jingfei Yang

и другие.

Cytotechnology, Год журнала: 2025, Номер 77(3)

Опубликована: Апрель 2, 2025

Язык: Английский

Процитировано

0
MiR-556-3p mediated repression of klotho under oxidative stress promotes fibrosis of renal tubular epithelial cells DOI Creative Commons
David Zhang, Zongying Li, Yuan Gao

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 9, 2025

Chronic kidney disease (CKD) is a global health issue characterized by renal fibrosis, which leads to irreversible tissue damage. Oxidative stress plays key role in driving the fibrotic processes associated with CKD. This study investigates roles of oxidative stress, miR-556-3p, and klotho tubular epithelial cells, focusing on their influence pathways. Using human cells HK-2, we conducted various vitro assays measure reactive oxygen species (ROS) levels, cell death, viability, proliferation. induced H2O2 treatment, was found suppress expression while increasing markers. Overexpression mitigated these effects, highlighting its protective against stress-induced fibrosis. Moreover, miR-556-3p upregulated response activated transcription factor Nuclear Factor Erythroid 2-Related 2 (Nrf2), contributing suppression klotho. Inhibition Nrf2, regulator responses, attenuated Targeting Nrf2-miR-556-3p-klotho axis may offer novel therapeutic avenues restore levels attenuate Our contributes significantly understanding molecular mechanisms CKD progression highlights potential targets for future pharmacological intervention.

Язык: Английский

Процитировано

0