Therapeutic Advances in Chronic Disease,
Год журнала:
2023,
Номер
14
Опубликована: Янв. 1, 2023
Background:
Diabetic
kidney
disease
(DKD)
is
a
serious
diabetic
complication
and
the
performance
of
serum
Klotho
in
DKD’s
prognostic
evaluation
controversial.
Objective:
To
assess
association
with
adverse
non-kidney
clinical
outcomes
patients
DKD.
Design:
Clinical
studies
regarding
relationship
DKD
were
included.
Study
quality
was
assessed
using
Newcastle–Ottawa
scale.
Subgroup
sensitive
analyses
performed
to
search
for
source
heterogeneity.
Data
sources
methods:
We
comprehensively
searched
PubMed,
Embase,
Web
Science,
Cochrane
library
databases
up
27
September
2022.
The
associations
albuminuria,
such
as
urinary
albumin
creatinine
ratio
(UACR),
persistent
estimated
glomerular
filtration
rate
decline,
retinopathy,
cardiovascular
morbidity,
mortality,
evaluated.
indicators,
correlation
coefficient
(
r),
odds
(OR),
relative
risk,
hazard
ratio,
retrieved
or
calculated
from
eligible
studies.
Results:
In
all,
17
involving
5682
participants
fulfilled
inclusion
criteria
included
this
meta-analysis.
There
no
significant
UACR
[summary
r,
−0.28
(−0.55,
0.04)]
high
By
contrast,
strong
observed
[pooled
OR,
1.60
(1.15,
2.23)],
2.78
(2.11,
3.66)],
combined
1.96
(1.45,
2.65)]
moderate
analysis
indicated
that
age,
study
design,
may
be
Conclusion:
A
decreased
level
possibly
associated
an
increased
risk
developing
patients;
thus,
possible
biomarker
predict
outcomes.
Additional
are
needed
clarify
validate
Klotho’s
value.
BMC Cardiovascular Disorders,
Год журнала:
2024,
Номер
24(1)
Опубликована: Ноя. 29, 2024
The
inverse
relationship
between
serum
Klotho
levels
and
systemic
inflammation,
particularly
C-reactive
protein
(CRP),
has
been
suggested
in
limited
studies.
However,
the
association
within
a
large
diverse
population
remains
underexplored.
We
conducted
cross-sectional
study
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
to
investigate
CRP
among
nationally
representative
sample
of
US
population.
Multiple
linear
regression
analyses
were
performed
assess
this
while
adjusting
for
relevant
covariates.
Stratified
analysis
with
interaction,
restricted
cubic
splines
(RCS)
employed
support
research
objectives.
A
total
5901
participants
had
mean
age
57.9
±
11.0
years,
49.4%
them
being
male
50.6%
female.
negative
was
revealed
fully
adjusted
model
(β
-0.26;
95%
CI
-0.41∼-0.11).
When
taken
as
quartiles
Q1
reference,
β
that
lowest
Q4
−
0.1
(95%
-0.16∼-0.04,
p-value
=
0.002)
4,
respectively.
These
statistics
robust
stratified
analyses.
While
our
demonstrates
an
CRP,
suggesting
potential
cardioprotective
role
Klotho,
it
is
important
note
design
does
not
permit
establishment
causality.
Therefore,
we
cannot
definitively
conclude
increasing
will
directly
reduce
cardiovascular
risk.
Our
findings
do,
however,
highlight
need
further
explore
therapeutic
target
health.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 17, 2024
Abstract
This
cross-sectional
study
examined
data
from
the
National
Health
and
Nutrition
Examination
Survey
(NHANES)
conducted
between
2007
2016,
ultimately
including
12,442
participants
to
explore
association
serum
Klotho
levels
asthma
prevalence.
IBL
ELISA
method,
while
diagnosis
relied
on
participant
responses
NHANES
questionnaires.
A
weighted
multifactorial
logistic
regression
analysis
evaluated
relationship,
a
smoothing
curve
assessed
potential
nonlinearity
.After
adjusting
for
confounding
variables,
significant
inverse
was
found
concentrations
incidence.
Specifically,
each
unit
increase
in
log-transformed
reduced
risk
by
48%
(OR:0.52;95%
CI:0.38–0.69).
The
also
revealed
that
lowest
quartile
had
higher
prevalence
of
compared
those
highest
(OR:0.58;95%
CI:0.45–0.76).Subgroup
analyses
indicated
interactions
related
drinking
status
history
cardiovascular
disease.
Notably,
did
not
identify
non-linear
relationship.
These
findings
suggest
lower
are
significantly
associated
with
middle-aged
elderly
Americans,
highlighting
need
further
cohort
studies
clarify
causal
relationship
these
variables.
Therapeutic Advances in Chronic Disease,
Год журнала:
2023,
Номер
14
Опубликована: Янв. 1, 2023
Background:
Diabetic
kidney
disease
(DKD)
is
a
serious
diabetic
complication
and
the
performance
of
serum
Klotho
in
DKD’s
prognostic
evaluation
controversial.
Objective:
To
assess
association
with
adverse
non-kidney
clinical
outcomes
patients
DKD.
Design:
Clinical
studies
regarding
relationship
DKD
were
included.
Study
quality
was
assessed
using
Newcastle–Ottawa
scale.
Subgroup
sensitive
analyses
performed
to
search
for
source
heterogeneity.
Data
sources
methods:
We
comprehensively
searched
PubMed,
Embase,
Web
Science,
Cochrane
library
databases
up
27
September
2022.
The
associations
albuminuria,
such
as
urinary
albumin
creatinine
ratio
(UACR),
persistent
estimated
glomerular
filtration
rate
decline,
retinopathy,
cardiovascular
morbidity,
mortality,
evaluated.
indicators,
correlation
coefficient
(
r),
odds
(OR),
relative
risk,
hazard
ratio,
retrieved
or
calculated
from
eligible
studies.
Results:
In
all,
17
involving
5682
participants
fulfilled
inclusion
criteria
included
this
meta-analysis.
There
no
significant
UACR
[summary
r,
−0.28
(−0.55,
0.04)]
high
By
contrast,
strong
observed
[pooled
OR,
1.60
(1.15,
2.23)],
2.78
(2.11,
3.66)],
combined
1.96
(1.45,
2.65)]
moderate
analysis
indicated
that
age,
study
design,
may
be
Conclusion:
A
decreased
level
possibly
associated
an
increased
risk
developing
patients;
thus,
possible
biomarker
predict
outcomes.
Additional
are
needed
clarify
validate
Klotho’s
value.
