The
influenza
virus
(IFV)
imposes
a
considerable
health
and
economic
burden
globally,
requiring
comprehensive
understanding
of
its
pathogenic
mechanisms.
Ferroptosis,
an
iron-dependent
lipid
peroxidation
cell
death
pathway,
holds
unique
implications
for
the
antioxidant
defense
system,
with
possible
contributions
to
inflammation.
This
exploration
focuses
on
dynamic
interplay
between
ferroptosis
host
against
viruses,
emphasizing
influence
IFV
infections
activation
pathway.
causes
different
types
death,
including
apoptosis,
necrosis,
ferroptosis.
IFV-induced
ferroptotic
is
mediated
by
alterations
in
iron
homeostasis,
intensifying
accumulation
reactive
oxygen
species
promoting
peroxidation.
A
investigation
into
mechanism
viral
infections,
specifically
IFV,
has
great
potential
identify
therapeutic
strategies.
may
pave
way
development
drugs
using
inhibitors,
presenting
effective
approach
suppress
infections.
Diabetes Metabolic Syndrome and Obesity,
Год журнала:
2024,
Номер
Volume 17, С. 3629 - 3641
Опубликована: Окт. 1, 2024
Coenzyme
Q
has
garnered
significant
attention
due
to
its
potential
role
in
enhancing
cellular
energy
production
and
antioxidant
properties.
We
delve
into
the
therapeutic
of
coenzyme
managing
diabetes
mellitus
complications,
highlighting
capacity
improve
mitochondrial
function,
reduce
inflammation
oxidative
stress,
correct
lipid
profiles.
shown
promise
ameliorating
insulin
resistance
alleviating
complications
such
as
diabetic
peripheral
neuropathy,
kidney
disease,
retinopathy,
cardiomyopathy.
However,
clinical
application
is
limited
by
poor
bio-availability.
This
review
also
provides
a
comprehensive
overview
current
strategies
for
involving
Q,
including
stimulating
endogenous
synthesis
utilizing
carrier
transport
systems,
offering
insights
mechanisms
These
findings
suggest
that,
with
improved
delivery
methods,
could
become
valuable
adjunct
therapy
management
mellitus.
Journal for Research in Applied Sciences and Biotechnology,
Год журнала:
2023,
Номер
2(5), С. 61 - 71
Опубликована: Окт. 25, 2023
Thirty
percent
of
all
deaths
that
occur
each
year
can
be
attributed
to
heart
disease,
stroke,
and
other
forms
cardiovascular
disease.
The
World
Health
Organisation
(WHO)
predicts
by
the
2030,
annual
death
toll
from
diseases
will
have
increased
22.2
million,
up
present
total
17.9
million.
Mortality
rates
tend
go
in
populations
as
they
get
older.
chance
dying
disease
is
significantly
higher
for
females
(51%)
than
it
males
(42%).
majority
people
treat
prevent
using
plant-based
medications
(also
known
phytochemicals),
either
addition
or
instead
pharmaceuticals
are
readily
available
on
market.
In
this
study,
efficacy
treating
illness
evaluated
92
different
plants,
including
15
terrestrial
plants.
A
number
medicinal
herbs,
Daucus
carota,
Nerium
oleander,
Amaranthus
Viridis,
Ginkgo
biloba,
Terminalia
arjuna,
Picrorhiza
kurroa,
Salvia
miltiorrhiza,
Tinospora
cordifolia,
Mucuna
pruriens,
Hydrocotyle
asiatica,
Bombax
ceiba,
Andrographis
paniculate,
utilised
There
a
variety
active
phytochemicals
found
these
some
which
include
flavonoids,
polyphenols,
plant
sterols,
sulphur
compounds,
terpenoids.
Flavonoids,
general,
increase
vasodilation
inhibiting
oxidation
low-density
lipoprotein
(LDL).
Plant
sterols
reduce
amount
cholesterol
blood,
turn
protects
against
compounds
protect
their
role
activation
nuclear
factor-erythroid
factor
2-related
2
(Nrf2)
inhibition
formation.
incidence
reduced
increasing
synthesis
ATP
mitochondria,
terpenoids
diminish
atherosclerotic
lesion
aortic
valve.
Even
though
several
physiologically
with
acknowledged
biological
functions
been
wide
prevalence
continues
rise,
making
imperative
effective
CVD
prevention
treatment
strategies
developed.
More
research
required
understand
both
mechanism
individual
plants
CVD.
GRAPHICAL
ABSTRACT
Journal of Prevention Diagnosis and Management of Human Diseases,
Год журнала:
2024,
Номер
42, С. 39 - 52
Опубликована: Март 9, 2024
Kidney
injury,
a
global
health
challenge,
necessitates
nuanced
understanding
of
molecular
intricacies
for
effective
interventions.
Long
non-coding
RNAs
(lncRNAs),
once
dismissed
as
transcriptional
noise,
now
emerge
pivotal
players
in
orchestrating
renal
health.
Dysregulation
specific
lncRNAs
like
TUG1,
MALAT1,
H19,
and
NEAT1
provides
signatures,
distinguishing
physiological
states
from
pathological
conditions.
In
acute
kidney
injury
(AKI),
TUG1
MALAT1
regulate
apoptosis,
inflammation,
fibrosis.
Chronic
disease
(CKD)
involves
H19
modulating
cell
proliferation
apoptosis.
Beyond
diagnostics,
actively
shape
fibrosis,
positioning
them
master
regulators
the
intricate
ballet
Recent
strides
research,
coupled
with
cutting-edge
genomics
bioinformatics
tools,
highlight
their
roles
therapeutic
potential.
Challenges
interactions
necessitate
exploration
promising
avenues,
including
single-cell
RNA
sequencing
artificial
intelligence,
paving
way
personalized
interventions
regenerative
medicine
diseases.
The
influenza
virus
(IFV)
imposes
a
considerable
health
and
economic
burden
globally,
requiring
comprehensive
understanding
of
its
pathogenic
mechanisms.
Ferroptosis,
an
iron-dependent
lipid
peroxidation
cell
death
pathway,
holds
unique
implications
for
the
antioxidant
defense
system,
with
possible
contributions
to
inflammation.
This
exploration
focuses
on
dynamic
interplay
between
ferroptosis
host
against
viruses,
emphasizing
influence
IFV
infections
activation
pathway.
causes
different
types
death,
including
apoptosis,
necrosis,
ferroptosis.
IFV-induced
ferroptotic
is
mediated
by
alterations
in
iron
homeostasis,
intensifying
accumulation
reactive
oxygen
species
promoting
peroxidation.
A
investigation
into
mechanism
viral
infections,
specifically
IFV,
has
great
potential
identify
therapeutic
strategies.
may
pave
way
development
drugs
using
inhibitors,
presenting
effective
approach
suppress
infections.
