Proteomics analysis reveals age-related proteins in the urine of chronic kidney disease patients

Frontiers in Medicine, Год журнала: 2025, Номер 11

Опубликована: Янв. 6, 2025

Chronic kidney disease (CKD) is closely linked to the aging process, making identification of protein biomarkers that reflect in specific organs and tissues crucial for a deeper understanding this phenomenon. This study aimed identify potential aging-related proteins present urine CKD patients. Utilizing liquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomic analysis, we identified total 1,712 samples from both healthy controls patients our discovery cohort. Among 845 overlapped, found 161 were associated with aging. By applying threshold p < 0.05 |log2 (fold change) | > 1.5, classified 114 as differentially expressed (DEPs). The analyzes conducted using Gene Ontology Kyoto Encyclopedia Genes Genomes revealed DEPs significantly enriched several clusters related In validation cohort, demonstrated exhibited lower urinary levels L-selectin (SELL), uromodulin (UMOD), epidermal growth factor (EGF). Additionally, significant negative correlation was between age EGF levels. estimated glomerular filtration rate (eGFR) showed positive SELL, UMOD, EGF, while 24-h proteinuria UMOD EGF. Furthermore, negatively correlated tubulointerstitial fibrosis, glomerulosclerosis. conclusion, emphasizes promise LC-MS/MS-based proteomics analysis identifying markers. Specifically, have been recognized promising indicators CKD.

Язык: Английский

---

Treadmill Exercise Modulates the Leptin/LepR/GSK-3β Signalling Pathway to Improve Leptin Sensitivity and Alleviate Neuroinflammation in High-Fat Diet-Fed APP/PS1 Mice

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

Язык: Английский

---

Serum amyloid beta 42 levels correlated with metabolic syndrome and its components

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Фев. 8, 2024

Introduction Beta-amyloid accumulation in the brain appears to be a key initiating event Alzheimer’s disease (AD), and factors associated with increased deposition of beta-amyloid are great interest. Enhanced amyloid-β peptides is due an imbalance between their production elimination. Previous studies show that diminished levels CSF amyloid beta 42 (Aβ42) biomarker AD; however, role serum Aβ42 AD contradictory. BMI obesity have been reported related levels. Therefore, we aimed investigate relation metabolic syndrome (MetS), its clinical measures (abdominal obesity, high glucose, triglyceride, low high-density lipoprotein cholesterol level, hypertension), Methods A total 1261 subjects, aged 18–89 years Chengdu, China, were enrolled from January 2020 2021 explore correlation body mass index (BMI), blood lipids, pressure. Furthermore, as risk MetS closely age, 1,212 participants ( N = 49 age ≥ 80 old excluded) analyzed for level measures. Results The results showed log-transformed was positively correlated R 0.29; p &lt; 0.001), triglyceride 0.14; diastolic pressure (DBP) 0.12; 0.001) negatively (HDL-c) −0.18; 0.001). After adjusting sex, other covariates, elevated higher values (βmodel1 2.694, βmodel2 2.703) DBP 0.541, 0.546) but lower HDL-c (βmodel2 −1.741). measures, including DBP, Han Chinese population. However, did not significant glucose or triglyceride. Discussion These observations indicate components hence limit potential suitable diagnostic AD. As such, recommend serve direct rather than

Язык: Английский

---

Neuro-Adipokine Crosstalk in Alzheimer’s Disease

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5932 - 5932

Опубликована: Май 29, 2024

The connection between body weight alterations and Alzheimer’s disease highlights the intricate relationship brain adipose tissue in context of neurological disorders. During midlife, gain increases risk cognitive decline dementia, whereas late life, becomes a protective factor. Despite their substantial impact on metabolism, role adipokines transition from healthy aging to disorders remains largely unexplored. We aim investigate how milieu secreted are involved biological pathological aging, highlighting bidirectional systemic metabolism. Understanding function these will allow us identify biomarkers for early detection uncover novel therapeutic options.

Язык: Английский

---

Integrating aging biomarkers and immune function to predict kidney health: insights from the future of families and child wellbeing study

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Окт. 21, 2024

Язык: Английский

---

Should We Consider Neurodegeneration by Itself or in a Triangulation with Neuroinflammation and Demyelination? The Example of Multiple Sclerosis and Beyond

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12637 - 12637

Опубликована: Ноя. 25, 2024

Neurodegeneration is preeminent in many neurological diseases, and still a major burden we fail to manage patient's care. Its pathogenesis complicated, intricate, far from being completely understood. Taking multiple sclerosis as an example, propose that neurodegeneration neither cause nor consequence by itself. Mitochondrial dysfunction, leading energy deficiency ion imbalance, plays key role neurodegeneration, partly caused the oxidative stress generated microglia astrocytes. Nodal paranodal disruption, with or without myelin alteration, further involved. Myelin loss exposes axons directly inflammatory environment. Moreover, oligodendrocytes provide singular metabolic trophic support axons, but do not emerge unscathed pathological events, primary defects cell apoptosis secondary neuroinflammation axonal damage. Hereby, failure might be overlooked contributor neurodegeneration. Thus, complex interplay between neuroinflammation, demyelination, wherein each primarily secondarily involved, offer more comprehensive understanding of help establishing novel therapeutic strategies for diseases beyond.

Язык: Английский

---

Association between Alzheimer’s disease and metabolic syndrome: Unveiling the role of dyslipidemia mechanisms

Опубликована: Дек. 1, 2024

Язык: Английский

---

Metabolic Side Effects from Antipsychotic Treatment with Clozapine Linked to Aryl Hydrocarbon Receptor (AhR) Activation

Biomedicines, Год журнала: 2024, Номер 12(10), С. 2294 - 2294

Опубликована: Окт. 10, 2024

Metabolic syndrome (MetS) is the most common adverse drug reaction from psychiatric pharmacotherapy. Neuroreceptor blockade by antipsychotic clozapine induces MetS in about 30% of patients. Similar to insulin resistance, impedes Akt kinase activation, leading intracellular glucose and glutathione depletion. Additional cystine shortage triggers tryptophan degradation kynurenine, which a well-known AhR ligand. Ligand-bound downregulates iron pool, thereby increasing risk mitochondrial dysfunction. Scavenging stabilizes transcription factor HIF-1, shifts metabolism toward transient glycolysis. Furthermore, inhibits AMPK obesity liver steatosis. Increasing uptake activation prevents dyslipidemia damage and, therefore, reduces MetS. In line with vitro results, feeding experiments rats revealed disturbed glucose-/lipid-/iron-metabolism treatment hyperglycemia hepatic deposits female steatosis anemia male animals. Decreased energy expenditure seems be cause fast weight gain first weeks treatment. patients, this due neuroleptic correlates an improvement psychotic syndromes can even used anticipate therapeutic effect

Язык: Английский

---

Extra virgin olive oil beneficial effects on memory, synaptic function, and neuroinflammation in a mouse model of Down syndrome

Journal of Alzheimer s Disease, Год журнала: 2024, Номер 102(1), С. 35 - 43

Опубликована: Окт. 4, 2024

Clinical and preclinical studies have shown that extra virgin olive oil (EVOO), a major component of the Mediterranean diet, has beneficial effects on brain aging cognition. Individuals with Down syndrome develop age-dependent cognitive decline synaptic dysfunction. However, whether EVOO intake is in not known.

Язык: Английский

---