Intergenerational risk of preterm birth in First Nations Australians: a population-based cohort study from the Northern Territory, Australia DOI Creative Commons
Holger W. Unger, Abel Fekadu Dadi, Kiarna Brown

и другие.

BMC Pregnancy and Childbirth, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 24, 2024

PTB increases the risk of health problems such as chronic renal disease and diabetes in later life adverse impacts are inversely correlated with gestational age at birth. Rates Northern Territory (NT) Australia amongst highest nationally globally, First Nations babies most affected. This study assessed magnitude potential drivers intergenerational recurrence NT. A retrospective cohort (1986–2017) was conducted 5,366 mothers born singleton who had 9,571 live births (7,673 Nations, 1,898 non-First babies). Maternal offspring categorised early (< 34 weeks) late (34–36 weeks). Modified Poisson regression used to estimate relative (RR) associated maternal PTB, adjusting for moderators receipt antenatal care prior PTB. Secondary analyses impact additional adjustment conditions a familial component, or that predisposes to, on estimate. Mediation analysis degree mediation maternal-offspring relationships by these conditions. Overall, women preterm 37 an increased delivering before weeks (aRR 1.28; 95%CI 1.08, 1.51). Women higher but not weeks): themselves 1.95, 1.17, 3.24) 1.41, 1.01, 1.97). Adjustment pre-eclampsia, intrauterine growth restriction, hypertensive attenuated observed associations. suggested may mediate up 26% recurrence. Similar trends were when first-time considered only. status women. have association is part driven pre-eclampsia disease. Routine inquiry birth be useful tool identify NT benefit from preventative measures.

Язык: Английский

Machine Learning Approach to Metabolomic Data Predicts Type 2 Diabetes Mellitus Incidence DOI Open Access
Andreas Leiherer, Axel Muendlein, Sylvia Mink

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(10), С. 5331 - 5331

Опубликована: Май 14, 2024

Metabolomics, with its wealth of data, offers a valuable avenue for enhancing predictions and decision-making in diabetes. This observational study aimed to leverage machine learning (ML) algorithms predict the 4-year risk developing type 2 diabetes mellitus (T2DM) using targeted quantitative metabolomics data. A cohort 279 cardiovascular patients who underwent coronary angiography were initially free T2DM according American Diabetes Association (ADA) criteria was analyzed at baseline, including anthropometric data metabolomics, liquid chromatography (LC)–mass spectroscopy (MS) flow injection analysis (FIA)–MS, respectively. All followed four years. During this time, 11.5% developed T2DM. After preprocessing, 362 variables used ML, employing Caret package R. The dataset divided into training test sets (75:25 ratio) we an oversampling approach address classifier imbalance incidence. additional recursive feature elimination step, identifying set 77 that most model generation, Support Vector Machine (SVM) linear kernel demonstrated promising predictive capabilities, exhibiting F1 score 50%, specificity 93%, balanced unbalanced accuracies 72% 88%, top-ranked features bile acids, ceramides, amino hexoses, whereas such as age, sex, waist circumference, or body mass index had no contribution. In conclusion, ML is tool individuals opens avenues personalized early intervention strategies.

Язык: Английский

Процитировано

4
Gestational diabetes mellitus-derived miR-7-19488 targets PIK3R2 mRNA to stimulate the abnormal development and maturation of offspring-islets DOI
Chunxue Xu,

Linhai Zou,

Li Wang

и другие.

Life Sciences, Год журнала: 2025, Номер 363, С. 123369 - 123369

Опубликована: Янв. 6, 2025

Язык: Английский

Процитировано

0
Glucose uptake in trophoblasts of GDM mice is regulated by the AMPK-CLUT3 signaling pathway DOI Creative Commons
Zhenghua Xiao, Xue Liu,

Xiaojin Luan

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 27, 2024

Abstract GDM, as a metabolic disease during pregnancy, regulates GLUT3 translocation by AMPK, thereby affecting glucose uptake in trophoblasts. It provides new research idea and therapeutic target for alleviating intrauterine hyperglycemia GDM. STZ was used to construct GDM mice, inject AICAR into pregnant observe fetal placental weight; flow cytometry employed the detection of primary trophoblast cells; immunofluorescence applied detect localization AMPK tissue; Cocofal microscope cells;qRT-PCR Western blot experiments were carried out expression levels CO-IP utilized interaction AMPK. Compared with normal pregnancy group, weight fetus placenta mice increased (P < 0.001), ability trophoblasts take up decreased 0.001). In addition, activity membrane down-regulated compared 0.05). There is an between Activating can up-regulate protein 0.05) increase We speculate that inhibition results aberrant GLUT3, which turn attenuates cells. activates improve capacity

Язык: Английский

Процитировано

1
Impact of Gestational Diabetes Mellitus on Fetal Growth and Nutritional Status in Newborns DOI Open Access
Karolina Karcz, Barbara Królak‐Olejnik

Nutrients, Год журнала: 2024, Номер 16(23), С. 4093 - 4093

Опубликована: Ноя. 27, 2024

Background: Gestational diabetes mellitus (GDM) is one of the most prevalent complications associated with pregnancy, exhibiting a gradual rise in prevalence worldwide. Given potential for numerous short- and long-term both mother child, patients diagnosed GDM require individualised treatment to compensate metabolic abnormalities ultimately reduce risk known adverse consequences impaired glucose tolerance. Methods results: The manuscript presents summary current knowledge on changes maternal metabolism during physiological pregnancy complicated by gestational diabetes. Furthermore, article provides synthesis findings from recent research examining impacts therapeutic modalities employed nutritional status fetus neonate. Additionally, review elucidates function placenta placental hormones fetal development, as well impact hyperglycemia, insulin resistance adipokines neonatal programming predisposition adulthood. Conclusions: environment, resulting abnormal tolerance exerts particularly significant growth and, consequently, birth weight fat mass newborn infants. This pivotal factor influencing developing fetus, predisposing individual development throughout their lifetime.

Язык: Английский

Процитировано

1
Maternal hyperglycemia affects cell proliferation signalling and stromal organization in the prostate of neonatal and juvenile rat offspring DOI

Luiz Felipe Fernandes Peixoto,

Laura Eduarda Dinato Sudário,

Marina das Graças Carneiro E Silva

и другие.

Acta Histochemica, Год журнала: 2024, Номер 126(8), С. 152193 - 152193

Опубликована: Сен. 7, 2024

Язык: Английский

Процитировано

0
Intergenerational risk of preterm birth in First Nations Australians: a population-based cohort study from the Northern Territory, Australia DOI Creative Commons
Holger W. Unger, Abel Fekadu Dadi, Kiarna Brown

и другие.

BMC Pregnancy and Childbirth, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 24, 2024

PTB increases the risk of health problems such as chronic renal disease and diabetes in later life adverse impacts are inversely correlated with gestational age at birth. Rates Northern Territory (NT) Australia amongst highest nationally globally, First Nations babies most affected. This study assessed magnitude potential drivers intergenerational recurrence NT. A retrospective cohort (1986–2017) was conducted 5,366 mothers born singleton who had 9,571 live births (7,673 Nations, 1,898 non-First babies). Maternal offspring categorised early (< 34 weeks) late (34–36 weeks). Modified Poisson regression used to estimate relative (RR) associated maternal PTB, adjusting for moderators receipt antenatal care prior PTB. Secondary analyses impact additional adjustment conditions a familial component, or that predisposes to, on estimate. Mediation analysis degree mediation maternal-offspring relationships by these conditions. Overall, women preterm 37 an increased delivering before weeks (aRR 1.28; 95%CI 1.08, 1.51). Women higher but not weeks): themselves 1.95, 1.17, 3.24) 1.41, 1.01, 1.97). Adjustment pre-eclampsia, intrauterine growth restriction, hypertensive attenuated observed associations. suggested may mediate up 26% recurrence. Similar trends were when first-time considered only. status women. have association is part driven pre-eclampsia disease. Routine inquiry birth be useful tool identify NT benefit from preventative measures.

Язык: Английский

Процитировано

0