Neurosurgical Review, Год журнала: 2024, Номер 48(1)
Опубликована: Дек. 26, 2024
Язык: Английский
Molecular Diagnosis & Therapy, Год журнала: 2024, Номер 28(3), С. 265 - 289
Опубликована: Март 31, 2024
Язык: Английский
Процитировано
11
Frontiers in Neurology, Год журнала: 2024, Номер 15
Опубликована: Апрель 2, 2024
Background Epilepsy is one of the most common serious chronic neurological disorders, which can have a negative impact on individuals, families and society, even death. With increasing application machine learning techniques in medicine recent years, integration with epilepsy has received close attention, potential to provide reliable optimal performance for clinical diagnosis, prediction, precision through use various types mathematical algorithms, promises make better parallel advances. However, no bibliometric assessment been conducted evaluate scientific progress this area. Therefore, study aims visually analyze trend current state research related bibliometrics visualization. Methods Relevant articles reviews were searched 2004–2023 using Web Science Core Collection database, analyses visualizations performed VOSviewer, CiteSpace, Bibliometrix (R-Tool R-Studio). Results A total 1,284 papers retrieved from Wo SCC database. The number shows an year by year. These mainly 1,957 organizations 87 countries/regions, majority United States China. journal highest published EPILEPSIA. Acharya, U. Rajendra (Ngee Ann Polytechnic, Singapore) authoritative author field his paper “Deep Convolutional Neural Networks Automated Detection Diagnosis Epileptic Seizures Using EEG Signals” was cited. Literature keyword analysis that seizure management neuroimaging are hotspots developments. Conclusions This first methods visualize areas epilepsy, revealing trends frontiers field. information will useful reference researchers focusing learning.
Язык: Английский
Процитировано
6
Frontiers in Oncology, Год журнала: 2025, Номер 15
Опубликована: Фев. 14, 2025
Background T follicular helper (TFH) cells, a subset of CD4 + Th play critical role in B cell activation, proliferation, and differentiation primarily within follicles secondary lymphoid organs, essential processes for effective antibody responses. TFH cells are also implicated various conditions, including autoimmune diseases, cancer, infectious allergies, vaccine reactions. Despite their broad impact, review the literature on tumors has not been conducted. We aimed to fill this gap by providing detailed analysis research landscape concerning tumors. Method conducted bibliometric from 2012 2024 using Web Science Core Collection (WoSCC). For an global landscape, we employed VOSviewer (version 1.6.20), CiteSpace 6.2.R6 software, “bibliometric” package R language 4.3.2) evaluate data countries/regions, authors cited authors, institutions, journals, references, keywords. systematic summarize trends, prospects, hotspots field. Results Our included contributions 60 7,864 35,853 1,756 385 academic 50883 222 keywords, 1,181published papers. Over past decade, volume had consistently increased. China published most papers, more than double that United States. The top 2 ranked publication were Gaulard, Philippe (14 articles, 379 citations), De leval, Laurence (12 236 citations) Notably, 9 10 institutions China. Frontiers Immunology Immunity leading journals publications citations. A cluster revealed shift focus “expression”,”B cells” “survival” “tumor microenvironment”, infiltrating immune “immune infiltration” recent years. Conclusion This suggests hold significant value potential clinical applications tumor immunotherapy. Moreover, offers valuable references guidance related endeavors. It points out prevailing issues challenges research, underscores need further basic advance fields.
Язык: Английский
Процитировано
0
European Journal of Endocrinology, Год журнала: 2025, Номер 192(2), С. 128 - 140
Опубликована: Фев. 1, 2025
Abstract Objective This study assessed CLDN16 as a potential replacement or improvement biomarker for papillary thyroid cancer (PTC), addressing the limitations associated with prevalently used BRAF-V600E mutation. Design Database analyses, tissue validation, RNA sequencing, and functional assays were conducted to evaluate PTC its clinical application. Methods expression was examined in normal thyroid/para-tumor tissues compared across various types. We evaluated diagnostic accuracy, stability primary metastatic sites, associations aggressive features. Knockdown experiments performed investigate impact on cell behavior. Additionally, we developed support vector machine model diagnosing malignant high-risk PTCs. Results demonstrated high specificity PTC, positive detection rates (88.0% The Cancer Genome Atlas [TCGA] 88.3% our center) significantly surpassing (47.5% TCGA 74.3% center). resulted superior accuracy (ROC-CLDN16 = 0.922 vs ROC-BRAF-V600E 0.742 TCGA). exhibited stable sites features, including extrathyroidal extension lymph node metastasis. knockdown inhibited migration, invasion, iodine uptake cells. Clinically, effectively identified malignancy BRAF wild patients (94.2%), combined BRAF-V600E, achieved 96.9% accuracy. incorporation of into molecular typing facilitated precise identification (92.0% training set 100% validation set). Conclusions presents promising that could surpass offering effective utility revolutionizing identification.
Язык: Английский
Процитировано
0
Cancer Science, Год журнала: 2025, Номер unknown
Опубликована: Март 5, 2025
γ-Glutamine cyclotransferase (GGCT) is an enzyme involved in the metabolic cycle of glutathione (GSH). Abnormal GSH metabolism mostly related to ferroptosis. However, mechanisms supporting aberrant GGCT expression PTC remain be investigated. In this study, we found that knockdown inhibited synthesis and promoted malondialdehyde (MDA) reactive oxygen species (ROS) accumulation, thereby promoting ferroptosis papillary thyroid cancer cells. Pro-GA, specific inhibitor GGCT, subcutaneous tumor formation K1 IP combined with LC-MS/MS showed interaction between RPS15A. RPS15A highly expressed tissues cells, promotes stability Knockdown p53 expression, which turn SLC7A11 resulting ferroptosis, while overexpression reversed GGCT-induced addition, miR-205-5p targeted 3' UTR inhibit GGCT-mediated growth, lung metastasis. conclusion, Mechanistically, interacts RPS15A, protein inhibits inhibiting synthesis. The upstream mechanism regulation by targeting GGCT.
Язык: Английский
Процитировано
0
Akıllı Ulaşım Sistemleri ve Uygulamaları Dergisi, Год журнала: 2025, Номер 8(1), С. 184 - 203
Опубликована: Март 19, 2025
This study conducts a bibliometric analysis of Intelligent Transportation Systems (ITS) research, using data from Web Science (WoS), Scopus, and TR Dizin covering 2015–2024. The reveals 440% increase in annual publications, driven by advancements artificial intelligence (AI), the Internet Things (IoT), sustainability-focused technologies. Dominant research themes include IoT, machine learning, smart city solutions, with sustainability-related topics such as eco-routing renewable energy integration gaining prominence. Geographic identifies India, China, United States leading contributors, while emerging economies like Turkey South Korea are expanding their footprints. Collaboration networks highlight interdisciplinary international partnerships, key hubs including MIT, Tsinghua University, Delft University Technology. Machine learning models predict steady growth ITS projecting approximately 950 outputs 2026. Despite progress, challenges remain, ethical concerns around autonomous vehicles, infrastructure integration, lack user-centric designs. emphasizes critical role addressing global transportation challenges, providing actionable insights for researchers, policymakers, industry stakeholders to advance sustainable, efficient, equitable mobility systems.
Язык: Английский
Процитировано
0
Journal of Immunology Research, Год журнала: 2025, Номер 2025(1)
Опубликована: Янв. 1, 2025
In recent years, a growing body of evidence has suggested correlation between Hashimoto’s thyroiditis (HT) and the onset progression papillary thyroid carcinoma (PTC). However, mechanism underlying relationship HT PTC remains incompletely understood. This review discusses literature on summarizes research concerning immunological interplay these two conditions. It also delves into tumor‐associated cells (such as CD8+ T cells), macrophages (TAMs), regulatory (Tregs), cancer‐associated fibroblasts (CAFs), alongside other factors, including interleukins (ILs), interferon‐gamma (IFN‐ γ ), tumor necrosis factor‐alpha (TNF‐ α cyclooxygenase‐2 (COX‐2), inducible nitric oxide synthase (iNOS), hypoxia‐inducible factor‐1 (HIF‐1), highlighting their roles in interaction HT. We explore strategic direction immunotherapy malignancies, particularly with HT, propose novel targeted immunotherapies for advanced cancer.
Язык: Английский
Процитировано
0
Asian Journal of Surgery, Год журнала: 2024, Номер unknown
Опубликована: Авг. 1, 2024
Follicular thyroid carcinoma (FTC), the second most prevalent cancer after papillary (PTC), tends to metastasize distantly, leading poorer outcomes. Despite substantial research, a holistic bibliometric analysis of FTC literature is lacking. This study aims fill this gap by employing methods track research evolution. English publications were systematically gathered from Web Science. Bibliometric analysis, using R, VOSviewer, CiteSpace, and Excel, synthesized data explored global trends topics. From 2000 2023, 9086 authors 1953 institutions across 75 countries contributed 1776 papers in 491 academic journals on FTC. The last two decades have witnessed steady increase related FTC, with United States terms publication volume. dominated both citations, National Cancer Institute Sheue-Yann Cheng as contributors. journal 'Thyroid' featured publications, while 'Journal Clinical Endocrinology Metabolism' ranked highest citation frequency. Research focused gene expression preoperative diagnostics, recent shifting toward prognosis management machine learning due advances medical technology increased health awareness. comprehensive has mapped landscape highlighting key contributors, institutions, thematic trends. Current discourse predominantly revolves around genetic prognostic determinants, diagnostics foundational work guides future providing insights into its
Язык: Английский
Процитировано
3
Surgical and Experimental Pathology, Год журнала: 2024, Номер 7(1)
Опубликована: Авг. 14, 2024
Abstract Thyroid cancer is one of the most common types worldwide. It a spectrum different diseases, ranging from very indolent to lethal tumors. Differentiated Carcinoma (DTC), thyroid malignancy, has often an excellent prognosis, but some patients develop metastatic Radioiodine-Refractory disease (RAIR) that cannot be controlled locally. In this setting, and for with Medullary (MTC) Anaplastic (ATC), systemic treatment non-selective Multikinase Inhibitors (MKIs) employed improve survival rates quality life. The molecular characterization showed main drivers carcinogenesis not only correlate morphological clinical features can targeted by modern highly selective Kinase Inhibitors: vemurafenib dabrafenib carcinomas BRAF V600E mutation, including Papillary (PTC) its subtypes; in association MEK1/2 inhibitor trametinib V600E-mutant ATC; larotrectinib entrectinib NTRK fusions selpercatinib pralsetinib MTC RET point mutations DTC -fusions. Apart those markers, Microsatellite Instability status (MSI), Tumor Mutation Burden (TMB) PD1/PD-L1 assessment have been explored tumors, although immunotherapy ATC shown modest results. Herein, we present comprehensive review relevant markers predictive value pathology.
Язык: Английский
Процитировано
1
Annals of Nuclear Medicine, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 5, 2024
Abstract The treatment of radioiodine-refractory differentiated thyroid cancer (RAIR-DTC) has made significant advancements in the twenty-first century. This study aimed to assess current state research and identify potential new directions by conducting a bibliometric analysis scientific publications on RAIR-DTC treatment. Publications relevant RAIR-DTC, published from January 1, 2000, December 31, 2023, were retrieved Web Science Core Collection. Bibliometric analyses major keywords, authors, countries, institutions, publications, journals conducted using CiteSpace VOSviewer. A total 859 papers included analysis. results demonstrated rising trend number over time. United States was identified as leading contributor terms publication output, citations, international collaborations. Gustave Roussy emerged top organization productivity, while journal Thyroid had highest related publications. RAIR categorized into three key hotspots: clinical trials targeted therapies, novel therapeutic strategies, debates surrounding management. is expanding trial phase tyrosine kinase inhibitor monotherapy more complex combination therapy strategy, particular, synergistic effect immune checkpoint inhibitors other agents, requiring high-quality prospective studies validate benefits. Moreover, timely identification patients holds enable early disease intervention, constituting pivotal direction future.
Язык: Английский
Процитировано
1