Neurosurgical Review, Год журнала: 2024, Номер 48(1)
Опубликована: Дек. 26, 2024
Язык: Английский
DNA and Cell Biology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 2, 2024
The number of cases papillary thyroid cancer (PTC) has gone up significantly in recent years, with high recurrence. Numerous reports have highlighted the participation circular RNAs (circRNAs) regulating advancement cancers, including PTC. Furthermore, studies suggest that N6-methyladenosine (m6A) modified circRNAs play pivotal roles progression. Hence, we studied potential role a novel circRNA, hsa_circ_0136959, and its regulatory mechanism on m6A modification by methyltransferase-like 3 (METTL3) tumor characteristics expressions hsa_circ_0136959 METTL3 were evaluated PTC samples cell lines via quantitative real-time polymerase chain reaction. effect malignant properties was analyzed performing Cell Counting Kit-8, colony formation, transwell assays. In addition, effects levels markers related to ferroptosis (reactive oxygen species, Fe2+, iron) cells also assessed. Bioinformatics analysis done determine expression sites it level through methylated RNA immunoprecipitation. observed be downregulated both cells. vitro experiments showed overexpression impeded Moreover, increased ferroptosis-related We found notably reduced positively correlated hsa_circ_0136959. Mechanistically, enhanced modification. Our results demonstrate METTL3-mediated elevated subsequently restricted accelerating ferroptosis.
Язык: Английский
Процитировано
1
Frontiers in Endocrinology, Год журнала: 2024, Номер 15
Опубликована: Май 31, 2024
The mucosa-associated lymphoid tissue (MALT) lymphoma subtype, specifically extranodal marginal zone B-cell lymphoma, is a rare variant. Within this primary thyroid MALT an uncommon occurrence. literature provides limited documentation on lymphomas, as their prevalence comparatively lower than in other organ sites. coexistence of papillary carcinoma (PTC) and lymphomas exceedingly rare. It presents case accompanied by PTC, not being considered before surgery. A 64-year-old female patient, who had been experiencing symptoms related to substantial tumor for duration three years, she refused do needle biopsy surgery expressed preference surgical resection. Consequently, the patient underwent total thyroidectomy along with lymphadenectomy central compartment. histological examination subsequently confirmed presence lymphoma. Due favorable response local treatment absence metastasis organs, no further was administered following Currently, exhibits signs recurrence based ultrasound laboratory evaluations. We also provide overview clinical findings PTC patients already reported discuss possible strategy.
Язык: Английский
Процитировано
0
Medicine, Год журнала: 2024, Номер 103(24), С. e37963 - e37963
Опубликована: Июнь 14, 2024
Graves' disease is a prevalent thyroid disorder and the primary cause of hyperthyroidism. Significant progress has been made in understanding epidemiology, pathogenesis, diagnosis, treatment, prognosis this disease. However, bibliometric analyses on are lacking. We aimed to comprehensively summarize research, progression, focal points through data mining integrated analysis existing literature.
Язык: Английский
Процитировано
0
The Journal of Contemporary Dental Practice, Год журнала: 2024, Номер 25(8), С. 803 - 808
Опубликована: Ноя. 26, 2024
To analyze the scientific literature on infrared thermography and thermal therapies in dentistry published between January 2019 August 2024 to identify trends, collaborations, impact of research this field.
Язык: Английский
Процитировано
0
Neurosurgical Review, Год журнала: 2024, Номер 48(1)
Опубликована: Дек. 26, 2024
Язык: Английский
Процитировано
0